BRD-K29905972_S1005_NPC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

213 genes differentially expressed following the BRD-K29905972_S1005_NPC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACAT2 acetyl-CoA acetyltransferase 2
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
AIM1 absent in melanoma 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALB albumin
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANPEP alanyl (membrane) aminopeptidase
AQP1 aquaporin 1 (Colton blood group)
ASPN asporin
ATP11B ATPase, class VI, type 11B
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BCAM basal cell adhesion molecule (Lutheran blood group)
BHLHE41 basic helix-loop-helix family, member e41
BID BH3 interacting domain death agonist
BLNK B-cell linker
BTG2 BTG family, member 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CCNB2 cyclin B2
CD24 CD24 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD93 CD93 molecule
CD99 CD99 molecule
CECR1 cat eye syndrome chromosome region, candidate 1
CEP70 centrosomal protein 70kDa
CES2 carboxylesterase 2
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL4A5 collagen, type IV, alpha 5
CPE carboxypeptidase E
CSTA cystatin A (stefin A)
DDIT4 DNA-damage-inducible transcript 4
DEFA4 defensin, alpha 4, corticostatin
DENND1B DENN/MADD domain containing 1B
DENND2D DENN/MADD domain containing 2D
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DPP4 dipeptidyl-peptidase 4
EDN1 endothelin 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ELANE elastase, neutrophil expressed
EPCAM epithelial cell adhesion molecule
FAM129A family with sequence similarity 129, member A
FAM69A family with sequence similarity 69, member A
FGFR2 fibroblast growth factor receptor 2
FHOD3 formin homology 2 domain containing 3
FOLR1 folate receptor 1 (adult)
FRY furry homolog (Drosophila)
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
HIST1H2BG histone cluster 1, H2bg
HLA-B major histocompatibility complex, class I, B
HLA-G major histocompatibility complex, class I, G
IGL immunoglobulin lambda locus
ITGB4 integrin, beta 4
JCHAIN joining chain of multimeric IgA and IgM
KLK5 kallikrein-related peptidase 5
KLK8 kallikrein-related peptidase 8
LCN2 lipocalin 2
LDOC1 leucine zipper, down-regulated in cancer 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MATN2 matrilin 2
MME membrane metallo-endopeptidase
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MSLN mesothelin
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYO1D myosin ID
NAT8 N-acetyltransferase 8 (GCN5-related, putative)
NCAPD2 non-SMC condensin I complex, subunit D2
NEB nebulin
NMRK1 nicotinamide riboside kinase 1
OGN osteoglycin
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDZK1IP1 PDZK1 interacting protein 1
PEG10 paternally expressed 10
PELI1 pellino E3 ubiquitin protein ligase 1
PLP2 proteolipid protein 2 (colonic epithelium-enriched)
PMM2 phosphomannomutase 2
PNRC1 proline-rich nuclear receptor coactivator 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PRNP prion protein
PRTN3 proteinase 3
PRUNE2 prune homolog 2 (Drosophila)
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
PTPRK protein tyrosine phosphatase, receptor type, K
PXN paxillin
RAB25 RAB25, member RAS oncogene family
REG1A regenerating islet-derived 1 alpha
RGCC regulator of cell cycle
RPP38 ribonuclease P/MRP 38kDa subunit
S100A8 S100 calcium binding protein A8
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SIRPA signal-regulatory protein alpha
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SOCS2 suppressor of cytokine signaling 2
SPINK1 serine peptidase inhibitor, Kazal type 1
STON1 stonin 1
SYNPO synaptopodin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFB1 transforming growth factor, beta 1
TGFBR3 transforming growth factor, beta receptor III
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TP53I3 tumor protein p53 inducible protein 3
TRIB3 tribbles pseudokinase 3
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC1 WAP four-disulfide core domain 1
WFS1 Wolfram syndrome 1 (wolframin)
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANXA5 annexin A5
ANXA6 annexin A6
ASCC3 activating signal cointegrator 1 complex subunit 3
BAX BCL2-associated X protein
BST2 bone marrow stromal cell antigen 2
CD59 CD59 molecule, complement regulatory protein
CDCA4 cell division cycle associated 4
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CLU clusterin
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CSRP1 cysteine and glycine-rich protein 1
CTSB cathepsin B
CTSL cathepsin L
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
EIF4A1 eukaryotic translation initiation factor 4A1
EIF4B eukaryotic translation initiation factor 4B
EIF5A eukaryotic translation initiation factor 5A
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM46A family with sequence similarity 46, member A
FSTL1 follistatin-like 1
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GAS1 growth arrest-specific 1
GPX1 glutathione peroxidase 1
GSTA4 glutathione S-transferase alpha 4
H1F0 H1 histone family, member 0
HMGA2 high mobility group AT-hook 2
HOMER1 homer scaffolding protein 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
ITGB5 integrin, beta 5
KPNB1 karyopherin (importin) beta 1
KRT10 keratin 10, type I
LAMC1 laminin, gamma 1 (formerly LAMB2)
LYPLA1 lysophospholipase I
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MFAP2 microfibrillar-associated protein 2
MUC5B mucin 5B, oligomeric mucus/gel-forming
NDN necdin, melanoma antigen (MAGE) family member
NME4 NME/NM23 nucleoside diphosphate kinase 4
NRN1 neuritin 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PALLD palladin, cytoskeletal associated protein
PDIA3 protein disulfide isomerase family A, member 3
PENK proenkephalin
PHLDA1 pleckstrin homology-like domain, family A, member 1
PRMT1 protein arginine methyltransferase 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RBBP4 retinoblastoma binding protein 4
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RGS4 regulator of G-protein signaling 4
RPIA ribose 5-phosphate isomerase A
RPS11 ribosomal protein S11
RPS27L ribosomal protein S27-like
SEC11A SEC11 homolog A (S. cerevisiae)
SEPW1 selenoprotein W, 1
SERBP1 SERPINE1 mRNA binding protein 1
SET SET nuclear proto-oncogene
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SPRY2 sprouty homolog 2 (Drosophila)
SRSF6 serine/arginine-rich splicing factor 6
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF3 trefoil factor 3 (intestinal)
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM45A transmembrane protein 45A
TNC tenascin C
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNPO1 transportin 1
TRIB2 tribbles pseudokinase 2
TSPAN13 tetraspanin 13
TSPAN3 tetraspanin 3
UGCG UDP-glucose ceramide glucosyltransferase
VCAN versican
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble