BRD-K29415052_NVP-BGT226_MCF7_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

283 genes differentially expressed following the BRD-K29415052_NVP-BGT226_MCF7_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AGR2 anterior gradient 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD10 ankyrin repeat domain 10
APOD apolipoprotein D
AREG amphiregulin
ARHGAP12 Rho GTPase activating protein 12
ASPN asporin
BIK BCL2-interacting killer (apoptosis-inducing)
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C1S complement component 1, s subcomponent
C6ORF48 chromosome 6 open reading frame 48
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK19 cyclin-dependent kinase 19
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL10A1 collagen, type X, alpha 1
CRISP3 cysteine-rich secretory protein 3
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CST1 cystatin SN
CST4 cystatin S
CTGF connective tissue growth factor
CTSA cathepsin A
CTSB cathepsin B
CTSL cathepsin L
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DNMBP dynamin binding protein
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EIF4B eukaryotic translation initiation factor 4B
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FAP fibroblast activation protein, alpha
FBLN1 fibulin 1
FBXW4 F-box and WD repeat domain containing 4
FHL2 four and a half LIM domains 2
FOXO3 forkhead box O3
FOXO4 forkhead box O4
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPATCH8 G patch domain containing 8
GPNMB glycoprotein (transmembrane) nmb
GRN granulin
GUSB glucuronidase, beta
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST3H2A histone cluster 3, H2a
HLA-E major histocompatibility complex, class I, E
HSPA2 heat shock 70kDa protein 2
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IL1R1 interleukin 1 receptor, type I
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDM3A lysine (K)-specific demethylase 3A
KLF5 Kruppel-like factor 5 (intestinal)
KLHL24 kelch-like family member 24
KRT18 keratin 18, type I
KYNU kynureninase
LAMB3 laminin, beta 3
LCN2 lipocalin 2
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
LOC100272216 uncharacterized LOC100272216
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K5 mitogen-activated protein kinase kinase 5
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MCOLN1 mucolipin 1
MFAP5 microfibrillar associated protein 5
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MKRN1 makorin ring finger protein 1
MLPH melanophilin
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
MUC5B mucin 5B, oligomeric mucus/gel-forming
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
N4BP2L2 NEDD4 binding protein 2-like 2
NBR1 neighbor of BRCA1 gene 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
OPTN optineurin
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PAWR PRKC, apoptosis, WT1, regulator
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PERP PERP, TP53 apoptosis effector
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLCB4 phospholipase C, beta 4
PNMA2 paraneoplastic Ma antigen 2
PPA1 pyrophosphatase (inorganic) 1
PROM1 prominin 1
PSAP prosaposin
QPCT glutaminyl-peptide cyclotransferase
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC16A6 solute carrier family 16, member 6
SMAD3 SMAD family member 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPATA20 spermatogenesis associated 20
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQSTM1 sequestosome 1
SRPX sushi-repeat containing protein, X-linked
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STX1A syntaxin 1A (brain)
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
SVIL supervillin
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TBX3 T-box 3
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGM2 transglutaminase 2
TMC5 transmembrane channel-like 5
TMPRSS2 transmembrane protease, serine 2
TPP1 tripeptidyl peptidase I
TRIM8 tripartite motif containing 8
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
USP9X ubiquitin specific peptidase 9, X-linked
VCL vinculin
VIM vimentin
VPS13B vacuolar protein sorting 13 homolog B (yeast)
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ASF1A anti-silencing function 1A histone chaperone
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
AUTS2 autism susceptibility candidate 2
BID BH3 interacting domain death agonist
BIRC5 baculoviral IAP repeat containing 5
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPN centromere protein N
CKS1B CDC28 protein kinase regulatory subunit 1B
CNN3 calponin 3, acidic
CPE carboxypeptidase E
CSRP2 cysteine and glycine-rich protein 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
DCK deoxycytidine kinase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
DOK5 docking protein 5
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ENO1 enolase 1, (alpha)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHA3 EPH receptor A3
EREG epiregulin
EXO1 exonuclease 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPX3 glutathione peroxidase 3
GRWD1 glutamate-rich WD repeat containing 1
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP5 insulin-like growth factor binding protein 5
ISG15 ISG15 ubiquitin-like modifier
ISOC1 isochorismatase domain containing 1
ITM2A integral membrane protein 2A
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa
NEK2 NIMA-related kinase 2
NES nestin
NREP neuronal regeneration related protein
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OIP5 Opa interacting protein 5
ORC6 origin recognition complex, subunit 6
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PHGDH phosphoglycerate dehydrogenase
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PXMP2 peroxisomal membrane protein 2, 22kDa
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RAD51C RAD51 paralog C
RBP1 retinol binding protein 1, cellular
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNASEH2A ribonuclease H2, subunit A
RPA3 replication protein A3, 14kDa
RRM1 ribonucleotide reductase M1
SDC2 syndecan 2
SEPHS1 selenophosphate synthetase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMC2 structural maintenance of chromosomes 2
SPC25 SPC25, NDC80 kinetochore complex component
SRM spermidine synthase
TACC3 transforming, acidic coiled-coil containing protein 3
TAGLN2 transgelin 2
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TMEM47 transmembrane protein 47
TMPO thymopoietin
TMSB15A thymosin beta 15a
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
UBE2C ubiquitin-conjugating enzyme E2C
UBE2N ubiquitin-conjugating enzyme E2N
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein