BRD-K29415052_NVP-BGT226_HT29_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

268 genes differentially expressed following the BRD-K29415052_NVP-BGT226_HT29_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACBD3 acyl-CoA binding domain containing 3
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMDHD2 amidohydrolase domain containing 2
AMIGO2 adhesion molecule with Ig-like domain 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRD10 ankyrin repeat domain 10
ANXA4 annexin A4
ARHGAP29 Rho GTPase activating protein 29
ASL argininosuccinate lyase
ATF4 activating transcription factor 4
BACE2 beta-site APP-cleaving enzyme 2
BASP1 brain abundant, membrane attached signal protein 1
BHLHE41 basic helix-loop-helix family, member e41
BTG1 B-cell translocation gene 1, anti-proliferative
C14ORF132 chromosome 14 open reading frame 132
C6ORF48 chromosome 6 open reading frame 48
CAPG capping protein (actin filament), gelsolin-like
CCL8 chemokine (C-C motif) ligand 8
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFD complement factor D (adipsin)
CLDN18 claudin 18
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
COL9A2 collagen, type IX, alpha 2
COL9A3 collagen, type IX, alpha 3
CRIP1 cysteine-rich protein 1 (intestinal)
CRISP3 cysteine-rich secretory protein 3
CST3 cystatin C
CTSA cathepsin A
CTSE cathepsin E
CYBA cytochrome b-245, alpha polypeptide
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DRAM1 DNA-damage regulated autophagy modulator 1
DST dystonin
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EFNB2 ephrin-B2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ETV5 ets variant 5
FAM134A family with sequence similarity 134, member A
FAM134B family with sequence similarity 134, member B
FAM13B family with sequence similarity 13, member B
FAM63A family with sequence similarity 63, member A
FBP1 fructose-1,6-bisphosphatase 1
FOXO4 forkhead box O4
FXYD3 FXYD domain containing ion transport regulator 3
GALE UDP-galactose-4-epimerase
GCC2 GRIP and coiled-coil domain containing 2
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GDF15 growth differentiation factor 15
GPATCH8 G patch domain containing 8
GPX2 glutathione peroxidase 2
GRN granulin
GSAP gamma-secretase activating protein
GSN gelsolin
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HLA-E major histocompatibility complex, class I, E
HNMT histamine N-methyltransferase
HOOK2 hook microtubule-tethering protein 2
IDS iduronate 2-sulfatase
IFI6 interferon, alpha-inducible protein 6
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD1C jumonji domain containing 1C
KDM3A lysine (K)-specific demethylase 3A
KRT18 keratin 18, type I
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS8 lectin, galactoside-binding, soluble, 8
MACF1 microtubule-actin crosslinking factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MET MET proto-oncogene, receptor tyrosine kinase
MFSD10 major facilitator superfamily domain containing 10
MGLL monoglyceride lipase
MLPH melanophilin
MTCL1 microtubule crosslinking factor 1
MTMR11 myotubularin related protein 11
MVP major vault protein
MX2 MX dynamin-like GTPase 2
NBPF10 neuroblastoma breakpoint family, member 10
NDRG1 N-myc downstream regulated 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
ORAI3 ORAI calcium release-activated calcium modulator 3
PDZK1IP1 PDZK1 interacting protein 1
PERP PERP, TP53 apoptosis effector
PFKL phosphofructokinase, liver
PIEZO2 piezo-type mechanosensitive ion channel component 2
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLEKHA5 pleckstrin homology domain containing, family A member 5
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPAP2B phosphatidic acid phosphatase type 2B
PPAP2C phosphatidic acid phosphatase type 2C
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKCZ protein kinase C, zeta
PRUNE2 prune homolog 2 (Drosophila)
RAB40B RAB40B, member RAS oncogene family
RABGAP1L RAB GTPase activating protein 1-like
RALGDS ral guanine nucleotide dissociation stimulator
RAP1GAP RAP1 GTPase activating protein
RIOK3 RIO kinase 3
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SH3YL1 SH3 and SYLF domain containing 1
SLC16A4 solute carrier family 16, member 4
SOX9 SRY (sex determining region Y)-box 9
SPATA20 spermatogenesis associated 20
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQSTM1 sequestosome 1
STK39 serine threonine kinase 39
STX1A syntaxin 1A (brain)
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYT17 synaptotagmin XVII
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TMC5 transmembrane channel-like 5
TMPRSS3 transmembrane protease, serine 3
TOX3 TOX high mobility group box family member 3
TPD52 tumor protein D52
TPD52L1 tumor protein D52-like 1
TPP1 tripeptidyl peptidase I
TSPAN8 tetraspanin 8
TSPO translocator protein (18kDa)
TST thiosulfate sulfurtransferase (rhodanese)
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAT1 vesicle amine transport 1
WDTC1 WD and tetratricopeptide repeats 1

decreased expression

Symbol Name
ADM adrenomedullin
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
BTG3 BTG family, member 3
C20ORF27 chromosome 20 open reading frame 27
CALD1 caldesmon 1
CCNA2 cyclin A2
CCNF cyclin F
CD163 CD163 molecule
CD99 CD99 molecule
CDC20 cell division cycle 20
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CSRP2 cysteine and glycine-rich protein 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EMP1 epithelial membrane protein 1
EMX2 empty spiracles homeobox 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FGFBP1 fibroblast growth factor binding protein 1
FKBP5 FK506 binding protein 5
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GRWD1 glutamate-rich WD repeat containing 1
H2AFV H2A histone family, member V
H2AFX H2A histone family, member X
HIST1H2BG histone cluster 1, H2bg
HMBS hydroxymethylbilane synthase
HMGB2 high mobility group box 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HPRT1 hypoxanthine phosphoribosyltransferase 1
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAL mal, T-cell differentiation protein
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
METTL3 methyltransferase like 3
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa
NEK2 NIMA-related kinase 2
NPY1R neuropeptide Y receptor Y1
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
NUSAP1 nucleolar and spindle associated protein 1
ODC1 ornithine decarboxylase 1
OIP5 Opa interacting protein 5
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDLIM1 PDZ and LIM domain 1
PLK1 polo-like kinase 1
POLD2 polymerase (DNA directed), delta 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PTTG1 pituitary tumor-transforming 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RANBP1 RAN binding protein 1
RBP1 retinol binding protein 1, cellular
RDX radixin
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SCARB2 scavenger receptor class B, member 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMC2 structural maintenance of chromosomes 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TCF4 transcription factor 4
TCTN1 tectonic family member 1
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TUBG1 tubulin, gamma 1
TWF1 twinfilin actin binding protein 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
VDAC3 voltage-dependent anion channel 3
VRK1 vaccinia related kinase 1
WHSC1 Wolf-Hirschhorn syndrome candidate 1
WT1 Wilms tumor 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein