BRD-K29415052_NVP-BGT226_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

140 genes differentially expressed following the BRD-K29415052_NVP-BGT226_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD2 abhydrolase domain containing 2
ABHD4 abhydrolase domain containing 4
AGTR1 angiotensin II receptor, type 1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA10 annexin A10
APOD apolipoprotein D
APOE apolipoprotein E
ARHGAP29 Rho GTPase activating protein 29
ASPN asporin
BGN biglycan
BHLHE41 basic helix-loop-helix family, member e41
C10ORF10 chromosome 10 open reading frame 10
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLEC2B C-type lectin domain family 2, member B
CST1 cystatin SN
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DHRS3 dehydrogenase/reductase (SDR family) member 3
DUSP6 dual specificity phosphatase 6
ERBB3 erb-b2 receptor tyrosine kinase 3
F12 coagulation factor XII (Hageman factor)
F5 coagulation factor V (proaccelerin, labile factor)
FABP4 fatty acid binding protein 4, adipocyte
FHL2 four and a half LIM domains 2
FOXO4 forkhead box O4
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GIMAP4 GTPase, IMAP family member 4
GLRX glutaredoxin (thioltransferase)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPG2 heparan sulfate proteoglycan 2
INPP1 inositol polyphosphate-1-phosphatase
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
LCN2 lipocalin 2
LIMA1 LIM domain and actin binding 1
LRP10 low density lipoprotein receptor-related protein 10
LY6E lymphocyte antigen 6 complex, locus E
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MARCKS myristoylated alanine-rich protein kinase C substrate
MMP7 matrix metallopeptidase 7
MTA1 metastasis associated 1
MVP major vault protein
MYO6 myosin VI
NOS3 nitric oxide synthase 3 (endothelial cell)
NT5E 5'-nucleotidase, ecto (CD73)
PDZK1IP1 PDZK1 interacting protein 1
PIP prolactin-induced protein
PLA1A phospholipase A1 member A
PPAP2C phosphatidic acid phosphatase type 2C
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS5 regulator of G-protein signaling 5
SEC14L1 SEC14-like 1 (S. cerevisiae)
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
SRGN serglycin
SRPX sushi-repeat containing protein, X-linked
SSFA2 sperm specific antigen 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS2 thrombospondin 2
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMC5 transmembrane channel-like 5
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN4 tetraspanin 4
TSPAN8 tetraspanin 8
VNN1 vanin 1
ZBTB16 zinc finger and BTB domain containing 16

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CIT citron rho-interacting serine/threonine kinase
CLIC3 chloride intracellular channel 3
CLU clusterin
CSRP2 cysteine and glycine-rich protein 2
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
F3 coagulation factor III (thromboplastin, tissue factor)
FEN1 flap structure-specific endonuclease 1
FOLR1 folate receptor 1 (adult)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPM6B glycoprotein M6B
H2AFV H2A histone family, member V
H2AFX H2A histone family, member X
HILPDA hypoxia inducible lipid droplet-associated
HIST1H2BG histone cluster 1, H2bg
HMGB2 high mobility group box 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IGL immunoglobulin lambda locus
IL1R1 interleukin 1 receptor, type I
KIF20A kinesin family member 20A
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAL mal, T-cell differentiation protein
MELK maternal embryonic leucine zipper kinase
NEK2 NIMA-related kinase 2
NR1H2 nuclear receptor subfamily 1, group H, member 2
NREP neuronal regeneration related protein
P3H2 prolyl 3-hydroxylase 2
PBK PDZ binding kinase
PCP4 Purkinje cell protein 4
PENK proenkephalin
PGAM1 phosphoglycerate mutase 1 (brain)
PLK1 polo-like kinase 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRC1 protein regulator of cytokinesis 1
PRDX2 peroxiredoxin 2
PTTG1 pituitary tumor-transforming 1
RRM2 ribonucleotide reductase M2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFN stratifin
SMC4 structural maintenance of chromosomes 4
SQLE squalene epoxidase
STMN1 stathmin 1
TK1 thymidine kinase 1, soluble
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
UBE2C ubiquitin-conjugating enzyme E2C