BRD-K29415052_NVP-BGT226_HCC515_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

242 genes differentially expressed following the BRD-K29415052_NVP-BGT226_HCC515_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADCY1 adenylate cyclase 1 (brain)
ADGRE5 adhesion G protein-coupled receptor E5
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
AMDHD2 amidohydrolase domain containing 2
ATF4 activating transcription factor 4
ATP9A ATPase, class II, type 9A
BAG1 BCL2-associated athanogene
BEX1 brain expressed, X-linked 1
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CA12 carbonic anhydrase XII
CAMLG calcium modulating ligand
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CDC25B cell division cycle 25B
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFD complement factor D (adipsin)
CIRBP cold inducible RNA binding protein
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLN3 ceroid-lipofuscinosis, neuronal 3
CLTA clathrin, light chain A
CREBL2 cAMP responsive element binding protein-like 2
CRIP1 cysteine-rich protein 1 (intestinal)
CRISP3 cysteine-rich secretory protein 3
CTSA cathepsin A
CTSD cathepsin D
DUSP3 dual specificity phosphatase 3
DUSP6 dual specificity phosphatase 6
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF4B eukaryotic translation initiation factor 4B
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
ERAP2 endoplasmic reticulum aminopeptidase 2
ERGIC3 ERGIC and golgi 3
ESYT1 extended synaptotagmin-like protein 1
FAM134A family with sequence similarity 134, member A
FAM171A1 family with sequence similarity 171, member A1
FAXDC2 fatty acid hydroxylase domain containing 2
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FXYD2 FXYD domain containing ion transport regulator 2
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GOLGA8H golgin A8 family, member H
GPATCH8 G patch domain containing 8
GRN granulin
GSN gelsolin
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HMG20B high mobility group 20B
HMOX1 heme oxygenase 1
HNMT histamine N-methyltransferase
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDS iduronate 2-sulfatase
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1R insulin-like growth factor 1 receptor
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ILK integrin-linked kinase
IRS2 insulin receptor substrate 2
JUND jun D proto-oncogene
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KYNU kynureninase
LAMP2 lysosomal-associated membrane protein 2
LETMD1 LETM1 domain containing 1
LPIN2 lipin 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K5 mitogen-activated protein kinase kinase 5
MOK MOK protein kinase
MSLN mesothelin
MTA1 metastasis associated 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MXI1 MAX interactor 1, dimerization protein
MYO1D myosin ID
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NFE2L1 nuclear factor, erythroid 2-like 1
NOV nephroblastoma overexpressed
NPC1 Niemann-Pick disease, type C1
NPTX2 neuronal pentraxin II
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDLIM5 PDZ and LIM domain 5
PHYH phytanoyl-CoA 2-hydroxylase
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PNMA1 paraneoplastic Ma antigen 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLR1D polymerase (RNA) I polypeptide D, 16kDa
QPCT glutaminyl-peptide cyclotransferase
RAB13 RAB13, member RAS oncogene family
RAP1GAP2 RAP1 GTPase activating protein 2
RB1CC1 RB1-inducible coiled-coil 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
RBM47 RNA binding motif protein 47
RIOK3 RIO kinase 3
RRAGC Ras-related GTP binding C
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEC11A SEC11 homolog A (S. cerevisiae)
SEPP1 selenoprotein P, plasma, 1
SFXN3 sideroflexin 3
SLC16A6 solute carrier family 16, member 6
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
STX1A syntaxin 1A (brain)
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYT1 synaptotagmin I
TCTA T-cell leukemia translocation altered
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TP53 tumor protein p53
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TSPAN4 tetraspanin 4
VAT1 vesicle amine transport 1
WDR13 WD repeat domain 13
WDTC1 WD and tetratricopeptide repeats 1
XYLT1 xylosyltransferase I
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
AK4 adenylate kinase 4
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALOX5 arachidonate 5-lipoxygenase
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATAD2 ATPase family, AAA domain containing 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CD36 CD36 molecule (thrombospondin receptor)
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK2 cyclin-dependent kinase 2
CHIC2 cysteine-rich hydrophobic domain 2
CNN3 calponin 3, acidic
CRELD2 cysteine-rich with EGF-like domains 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRP2 cysteine and glycine-rich protein 2
CST7 cystatin F (leukocystatin)
CTSZ cathepsin Z
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DDIT4 DNA-damage-inducible transcript 4
DMD dystrophin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FEN1 flap structure-specific endonuclease 1
FGF2 fibroblast growth factor 2 (basic)
FGFBP1 fibroblast growth factor binding protein 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GOLT1B golgi transport 1B
GPM6B glycoprotein M6B
GSTA4 glutathione S-transferase alpha 4
HELLS helicase, lymphoid-specific
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
ICMT isoprenylcysteine carboxyl methyltransferase
IFITM1 interferon induced transmembrane protein 1
IFRD2 interferon-related developmental regulator 2
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IL1RL1 interleukin 1 receptor-like 1
IL32 interleukin 32
KCTD12 potassium channel tetramerization domain containing 12
KRT5 keratin 5, type II
LMNB1 lamin B1
LTF lactotransferrin
LY6D lymphocyte antigen 6 complex, locus D
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MINA MYC induced nuclear antigen
MNDA myeloid cell nuclear differentiation antigen
MPHOSPH6 M-phase phosphoprotein 6
NES nestin
NOLC1 nucleolar and coiled-body phosphoprotein 1
NRIP1 nuclear receptor interacting protein 1
NTS neurotensin
NXT1 nuclear transport factor 2-like export factor 1
OAT ornithine aminotransferase
PCNA proliferating cell nuclear antigen
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PLBD1 phospholipase B domain containing 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRMT1 protein arginine methyltransferase 1
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
QDPR quinoid dihydropteridine reductase
RAD51C RAD51 paralog C
RANBP1 RAN binding protein 1
REG3A regenerating islet-derived 3 alpha
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RGS2 regulator of G-protein signaling 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SDF2L1 stromal cell-derived factor 2-like 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC43A3 solute carrier family 43, member 3
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SPAG6 sperm associated antigen 6
SPRR3 small proline-rich protein 3
SRM spermidine synthase
STIP1 stress-induced phosphoprotein 1
TF transferrin
TFDP1 transcription factor Dp-1
TFRC transferrin receptor
TK1 thymidine kinase 1, soluble
TMEM109 transmembrane protein 109
TMEM123 transmembrane protein 123
TPD52L1 tumor protein D52-like 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIP13 thyroid hormone receptor interactor 13
TRPS1 trichorhinophalangeal syndrome I
TUBG1 tubulin, gamma 1
VCAN versican
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon