BRD-K29415052_NVP-BGT226_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

206 genes differentially expressed following the BRD-K29415052_NVP-BGT226_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP17A A kinase (PRKA) anchor protein 17A
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AMDHD2 amidohydrolase domain containing 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ATP9A ATPase, class II, type 9A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BMP2 bone morphogenetic protein 2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CXCL13 chemokine (C-X-C motif) ligand 13
DCLK1 doublecortin-like kinase 1
DDIT3 DNA-damage-inducible transcript 3
DOCK9 dedicator of cytokinesis 9
EMP1 epithelial membrane protein 1
FAM102A family with sequence similarity 102, member A
FOXG1 forkhead box G1
GSN gelsolin
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGHMBP2 immunoglobulin mu binding protein 2
INSR insulin receptor
IRS2 insulin receptor substrate 2
KDSR 3-ketodihydrosphingosine reductase
KYNU kynureninase
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
MAST4 microtubule associated serine/threonine kinase family member 4
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MTA1 metastasis associated 1
N4BP2L2 NEDD4 binding protein 2-like 2
NPC1 Niemann-Pick disease, type C1
OLFM1 olfactomedin 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDGFA platelet-derived growth factor alpha polypeptide
PPAP2C phosphatidic acid phosphatase type 2C
PPL periplakin
RBM39 RNA binding motif protein 39
SAT1 spermidine/spermine N1-acetyltransferase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SQSTM1 sequestosome 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STX1A syntaxin 1A (brain)
SWAP70 SWAP switching B-cell complex 70kDa subunit
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TSC22D1 TSC22 domain family, member 1
WASF3 WAS protein family, member 3

decreased expression

Symbol Name
ACTB actin, beta
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AK4 adenylate kinase 4
ALCAM activated leukocyte cell adhesion molecule
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BASP1 brain abundant, membrane attached signal protein 1
BCHE butyrylcholinesterase
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CALD1 caldesmon 1
CCNA2 cyclin A2
CD24 CD24 molecule
CD47 CD47 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CKAP4 cytoskeleton-associated protein 4
CLIC3 chloride intracellular channel 3
CNN3 calponin 3, acidic
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
COMP cartilage oligomeric matrix protein
CPE carboxypeptidase E
CSRP1 cysteine and glycine-rich protein 1
CTSC cathepsin C
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DCN decorin
DEPTOR DEP domain containing MTOR-interacting protein
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGLN3 egl-9 family hypoxia-inducible factor 3
ENO1 enolase 1, (alpha)
EPHA3 EPH receptor A3
ESR1 estrogen receptor 1
FAM162A family with sequence similarity 162, member A
FHL1 four and a half LIM domains 1
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
FZD2 frizzled class receptor 2
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GDE1 glycerophosphodiester phosphodiesterase 1
GJA1 gap junction protein, alpha 1, 43kDa
GLIPR1 GLI pathogenesis-related 1
GPX3 glutathione peroxidase 3
GSTM3 glutathione S-transferase mu 3 (brain)
GTF2A2 general transcription factor IIA, 2, 12kDa
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H2BFS H2B histone family, member S (pseudogene)
HILPDA hypoxia inducible lipid droplet-associated
HOPX HOP homeobox
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
JCHAIN joining chain of multimeric IgA and IgM
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIF20A kinesin family member 20A
LAMP1 lysosomal-associated membrane protein 1
LAMP5 lysosomal-associated membrane protein family, member 5
LAPTM4B lysosomal protein transmembrane 4 beta
LEF1 lymphoid enhancer-binding factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOC100505650 uncharacterized LOC100505650
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LRRC17 leucine rich repeat containing 17
MAGED1 melanoma antigen family D1
MATN2 matrilin 2
MDK midkine (neurite growth-promoting factor 2)
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
MLEC malectin
MSMO1 methylsterol monooxygenase 1
MYCBP MYC binding protein
NEFH neurofilament, heavy polypeptide
NMU neuromedin U
NNMT nicotinamide N-methyltransferase
NREP neuronal regeneration related protein
NSF N-ethylmaleimide-sensitive factor
OLFML3 olfactomedin-like 3
OXR1 oxidation resistance 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HB prolyl 4-hydroxylase, beta polypeptide
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PALLD palladin, cytoskeletal associated protein
PAX8 paired box 8
PCP4 Purkinje cell protein 4
PDIA3 protein disulfide isomerase family A, member 3
PDIA6 protein disulfide isomerase family A, member 6
PFN2 profilin 2
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PGRMC1 progesterone receptor membrane component 1
PHGDH phosphoglycerate dehydrogenase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PKM pyruvate kinase, muscle
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRDX4 peroxiredoxin 4
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PYCR1 pyrroline-5-carboxylate reductase 1
QPRT quinolinate phosphoribosyltransferase
RHOB ras homolog family member B
S100A8 S100 calcium binding protein A8
SDC2 syndecan 2
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLPI secretory leukocyte peptidase inhibitor
SMYD3 SET and MYND domain containing 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPTSSA serine palmitoyltransferase, small subunit A
SQLE squalene epoxidase
SRGN serglycin
SSR1 signal sequence receptor, alpha
STMN1 stathmin 1
TFF3 trefoil factor 3 (intestinal)
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TLE4 transducin-like enhancer of split 4
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM2 transmembrane protein 2
TMX1 thioredoxin-related transmembrane protein 1
TPM1 tropomyosin 1 (alpha)
TPM4 tropomyosin 4
TUBB tubulin, beta class I
TUSC3 tumor suppressor candidate 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VKORC1 vitamin K epoxide reductase complex, subunit 1
WNT5A wingless-type MMTV integration site family, member 5A