BRD-K29415052_NVP-BGT226_HA1E_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

206 genes differentially expressed following the BRD-K29415052_NVP-BGT226_HA1E_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG6 adhesion G protein-coupled receptor G6
ADIRF adipogenesis regulatory factor
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
AMDHD2 amidohydrolase domain containing 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ASPN asporin
C14ORF159 chromosome 14 open reading frame 159
C2CD5 C2 calcium-dependent domain containing 5
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CDC25B cell division cycle 25B
CDK19 cyclin-dependent kinase 19
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CXADR coxsackie virus and adenovirus receptor
DST dystonin
EIF5 eukaryotic translation initiation factor 5
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
FOXG1 forkhead box G1
FXR1 fragile X mental retardation, autosomal homolog 1
GAB2 GRB2-associated binding protein 2
GADD45B growth arrest and DNA-damage-inducible, beta
GALC galactosylceramidase
GLOD4 glyoxalase domain containing 4
GLTSCR2 glioma tumor suppressor candidate region gene 2
GPX4 glutathione peroxidase 4
GUSB glucuronidase, beta
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HOXA5 homeobox A5
INSM1 insulinoma-associated 1
INSR insulin receptor
IRS2 insulin receptor substrate 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
LETMD1 LETM1 domain containing 1
LHX2 LIM homeobox 2
MAP2K5 mitogen-activated protein kinase kinase 5
MCUR1 mitochondrial calcium uniporter regulator 1
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MTA1 metastasis associated 1
NEBL nebulette
NID1 nidogen 1
NPC1 Niemann-Pick disease, type C1
NR1D2 nuclear receptor subfamily 1, group D, member 2
PAN2 PAN2 poly(A) specific ribonuclease subunit
PER3 period circadian clock 3
PHF3 PHD finger protein 3
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PNKP polynucleotide kinase 3'-phosphatase
POSTN periostin, osteoblast specific factor
RPS11 ribosomal protein S11
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SEPT10 septin 10
SET SET nuclear proto-oncogene
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SPATA20 spermatogenesis associated 20
SPRY2 sprouty homolog 2 (Drosophila)
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SRPX sushi-repeat containing protein, X-linked
STX1A syntaxin 1A (brain)
SYNE2 spectrin repeat containing, nuclear envelope 2
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TCTA T-cell leukemia translocation altered
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGM2 transglutaminase 2
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TPP1 tripeptidyl peptidase I
WDR13 WD repeat domain 13
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ADI1 acireductone dioxygenase 1
AK4 adenylate kinase 4
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALDOC aldolase C, fructose-bisphosphate
ASS1 argininosuccinate synthase 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C3 complement component 3
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CBR1 carbonyl reductase 1
CCDC92 coiled-coil domain containing 92
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD47 CD47 molecule
CD58 CD58 molecule
CKAP4 cytoskeleton-associated protein 4
CPE carboxypeptidase E
CREB3L2 cAMP responsive element binding protein 3-like 2
CTSC cathepsin C
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DHCR24 24-dehydrocholesterol reductase
DMTF1 cyclin D binding myb-like transcription factor 1
EGLN3 egl-9 family hypoxia-inducible factor 3
ENO1 enolase 1, (alpha)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESR1 estrogen receptor 1
FADS2 fatty acid desaturase 2
FAM162A family with sequence similarity 162, member A
FKBP14 FK506 binding protein 14, 22 kDa
FOLR1 folate receptor 1 (adult)
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GCLM glutamate-cysteine ligase, modifier subunit
GDE1 glycerophosphodiester phosphodiesterase 1
GPI glucose-6-phosphate isomerase
GREB1 growth regulation by estrogen in breast cancer 1
GSTM3 glutathione S-transferase mu 3 (brain)
GTF2A2 general transcription factor IIA, 2, 12kDa
H2BFS H2B histone family, member S (pseudogene)
HIPK1 homeodomain interacting protein kinase 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPB8 heat shock 22kDa protein 8
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IL32 interleukin 32
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
LCN2 lipocalin 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOXL1 lysyl oxidase-like 1
LRRC59 leucine rich repeat containing 59
MAGED1 melanoma antigen family D1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1A microtubule-associated protein 1A
MATN2 matrilin 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLEC malectin
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMO1 methylsterol monooxygenase 1
MT1E metallothionein 1E
MXRA7 matrix-remodelling associated 7
MYD88 myeloid differentiation primary response 88
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NOTCH2 notch 2
ODC1 ornithine decarboxylase 1
OPN3 opsin 3
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
P4HB prolyl 4-hydroxylase, beta polypeptide
PANX1 pannexin 1
PCP4 Purkinje cell protein 4
PDAP1 PDGFA associated protein 1
PDIA3 protein disulfide isomerase family A, member 3
PFN2 profilin 2
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHGDH phosphoglycerate dehydrogenase
PKM pyruvate kinase, muscle
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRDX4 peroxiredoxin 4
PSAT1 phosphoserine aminotransferase 1
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
PTGDS prostaglandin D2 synthase 21kDa (brain)
QPRT quinolinate phosphoribosyltransferase
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RHOB ras homolog family member B
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
S100A10 S100 calcium binding protein A10
S100A9 S100 calcium binding protein A9
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCRG1 stimulator of chondrogenesis 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLPI secretory leukocyte peptidase inhibitor
SOD2 superoxide dismutase 2, mitochondrial
SQLE squalene epoxidase
STC2 stanniocalcin 2
TCF4 transcription factor 4
TCTN1 tectonic family member 1
TMEM100 transmembrane protein 100
TMEM45A transmembrane protein 45A
TMEM47 transmembrane protein 47
TNC tenascin C
VLDLR very low density lipoprotein receptor
XBP1 X-box binding protein 1