BRD-K29415052_NVP-BGT226_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

283 genes differentially expressed following the BRD-K29415052_NVP-BGT226_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRE5 adhesion G protein-coupled receptor E5
AHNAK2 AHNAK nucleoprotein 2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AMDHD2 amidohydrolase domain containing 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APOD apolipoprotein D
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF4 activating transcription factor 4
ATM ATM serine/threonine kinase
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
C6ORF48 chromosome 6 open reading frame 48
CAPN3 calpain 3, (p94)
CCDC85B coiled-coil domain containing 85B
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK19 cyclin-dependent kinase 19
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDK7 cyclin-dependent kinase 7
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CNPY3 canopy FGF signaling regulator 3
CRISP3 cysteine-rich secretory protein 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSK cathepsin K
DARS aspartyl-tRNA synthetase
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DEPTOR DEP domain containing MTOR-interacting protein
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DOCK9 dedicator of cytokinesis 9
DTNA dystrobrevin, alpha
DUSP10 dual specificity phosphatase 10
DUSP5 dual specificity phosphatase 5
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF3L eukaryotic translation initiation factor 3, subunit L
EIF3M eukaryotic translation initiation factor 3, subunit M
EIF4B eukaryotic translation initiation factor 4B
ETV1 ets variant 1
FAM134A family with sequence similarity 134, member A
FAR2 fatty acyl CoA reductase 2
FN1 fibronectin 1
FOXO1 forkhead box O1
GALE UDP-galactose-4-epimerase
GATAD1 GATA zinc finger domain containing 1
GCC2 GRIP and coiled-coil domain containing 2
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPATCH8 G patch domain containing 8
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSE1 Gse1 coiled-coil protein
H1F0 H1 histone family, member 0
HACD1 3-hydroxyacyl-CoA dehydratase 1
HLA-E major histocompatibility complex, class I, E
HMGA1 high mobility group AT-hook 1
IDS iduronate 2-sulfatase
IGBP1 immunoglobulin (CD79A) binding protein 1
IGSF1 immunoglobulin superfamily, member 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IPO7 importin 7
ISG20 interferon stimulated exonuclease gene 20kDa
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDM5B lysine (K)-specific demethylase 5B
KDSR 3-ketodihydrosphingosine reductase
KLF5 Kruppel-like factor 5 (intestinal)
KPNA4 karyopherin alpha 4 (importin alpha 3)
KYNU kynureninase
LAMB3 laminin, beta 3
LETMD1 LETM1 domain containing 1
LIF leukemia inhibitory factor
LMO3 LIM domain only 3 (rhombotin-like 2)
LOC399491
LONP2 lon peptidase 2, peroxisomal
LPIN1 lipin 1
LRPPRC leucine-rich pentatricopeptide repeat containing
LUM lumican
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K5 mitogen-activated protein kinase kinase 5
MAP7 microtubule-associated protein 7
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MET MET proto-oncogene, receptor tyrosine kinase
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MLPH melanophilin
MNT MAX network transcriptional repressor
MTA1 metastasis associated 1
MVP major vault protein
MZF1 myeloid zinc finger 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NPAS2 neuronal PAS domain protein 2
NPDC1 neural proliferation, differentiation and control, 1
NR1D2 nuclear receptor subfamily 1, group D, member 2
NRN1 neuritin 1
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PAMR1 peptidase domain containing associated with muscle regeneration 1
PARP6 poly (ADP-ribose) polymerase family, member 6
PDLIM1 PDZ and LIM domain 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PILRB paired immunoglobin-like type 2 receptor beta
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PNKP polynucleotide kinase 3'-phosphatase
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPA1 pyrophosphatase (inorganic) 1
PPIE peptidylprolyl isomerase E (cyclophilin E)
PPL periplakin
PRAF2 PRA1 domain family, member 2
PSD3 pleckstrin and Sec7 domain containing 3
PTP4A1 protein tyrosine phosphatase type IVA, member 1
QPCT glutaminyl-peptide cyclotransferase
R3HDM2 R3H domain containing 2
RALGDS ral guanine nucleotide dissociation stimulator
RBKS ribokinase
RBM34 RNA binding motif protein 34
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNMT RNA (guanine-7-) methyltransferase
RPL14 ribosomal protein L14
RPL22 ribosomal protein L22
RPL28 ribosomal protein L28
RPL31 ribosomal protein L31
RPL36 ribosomal protein L36
RPL4 ribosomal protein L4
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RSL1D1 ribosomal L1 domain containing 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD5 stearoyl-CoA desaturase 5
SFRP4 secreted frizzled-related protein 4
SH3YL1 SH3 and SYLF domain containing 1
SLC16A6 solute carrier family 16, member 6
SLC22A18 solute carrier family 22, member 18
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SPATA20 spermatogenesis associated 20
SQSTM1 sequestosome 1
SRPX sushi-repeat containing protein, X-linked
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STK26 serine/threonine protein kinase 26
STX1A syntaxin 1A (brain)
SYNJ2 synaptojanin 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TCEAL4 transcription elongation factor A (SII)-like 4
TCTA T-cell leukemia translocation altered
TGM2 transglutaminase 2
TGM4 transglutaminase 4
TM4SF1 transmembrane 4 L six family member 1
TMEM30B transmembrane protein 30B
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TPD52 tumor protein D52
TPP1 tripeptidyl peptidase I
TSPAN4 tetraspanin 4
TSPAN8 tetraspanin 8
TSPO translocator protein (18kDa)
TUG1 taurine up-regulated 1 (non-protein coding)
UFM1 ubiquitin-fold modifier 1
VEGFC vascular endothelial growth factor C
WEE1 WEE1 G2 checkpoint kinase
ZDHHC11 zinc finger, DHHC-type containing 11
ZFAND1 zinc finger, AN1-type domain 1
ZNF277 zinc finger protein 277
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
ALDOC aldolase C, fructose-bisphosphate
BCHE butyrylcholinesterase
BST2 bone marrow stromal cell antigen 2
C7 complement component 7
CBR1 carbonyl reductase 1
CCND3 cyclin D3
CD320 CD320 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD93 CD93 molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CTSC cathepsin C
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DSE dermatan sulfate epimerase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECI2 enoyl-CoA delta isomerase 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENDOD1 endonuclease domain containing 1
FABP4 fatty acid binding protein 4, adipocyte
FABP6 fatty acid binding protein 6, ileal
FEN1 flap structure-specific endonuclease 1
FSTL1 follistatin-like 1
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCLM glutamate-cysteine ligase, modifier subunit
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GRWD1 glutamate-rich WD repeat containing 1
GTF2A2 general transcription factor IIA, 2, 12kDa
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA14 heat shock 70kDa protein 14
HSPA1A heat shock 70kDa protein 1A
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IL32 interleukin 32
KCTD12 potassium channel tetramerization domain containing 12
KIF20A kinesin family member 20A
KRT5 keratin 5, type II
LBR lamin B receptor
LCK LCK proto-oncogene, Src family tyrosine kinase
LMNB1 lamin B1
LMO2 LIM domain only 2 (rhombotin-like 1)
LSM1 LSM1, U6 small nuclear RNA associated
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MCM10 minichromosome maintenance complex component 10
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NR2F2 nuclear receptor subfamily 2, group F, member 2
NT5DC2 5'-nucleotidase domain containing 2
OSBPL8 oxysterol binding protein-like 8
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDZK1 PDZ domain containing 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGAM1 phosphoglycerate mutase 1 (brain)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PODXL podocalyxin-like
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTK2 protein tyrosine kinase 2
PXDN peroxidasin
RAD51C RAD51 paralog C
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RHOB ras homolog family member B
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A4 S100 calcium binding protein A4
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SNN stannin
SOSTDC1 sclerostin domain containing 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
STK17A serine/threonine kinase 17a
STMN1 stathmin 1
TACC1 transforming, acidic coiled-coil containing protein 1
TCTN1 tectonic family member 1
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TMEM109 transmembrane protein 109
TMEM14A transmembrane protein 14A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TUBB2A tubulin, beta 2A class IIa
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
VDAC1 voltage-dependent anion channel 1
VGLL4 vestigial-like family member 4
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
WT1 Wilms tumor 1
ZFP36L1 ZFP36 ring finger protein-like 1