BRD-K29173907_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

76 genes differentially expressed following the BRD-K29173907_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCNE2 cyclin E2
CD40 CD40 molecule, TNF receptor superfamily member 5
CD52 CD52 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
COL11A1 collagen, type XI, alpha 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYBA cytochrome b-245, alpha polypeptide
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDIT4 DNA-damage-inducible transcript 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DHCR24 24-dehydrocholesterol reductase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF5A eukaryotic translation initiation factor 5A
ERBB3 erb-b2 receptor tyrosine kinase 3
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOLR1 folate receptor 1 (adult)
HOXD1 homeobox D1
JADE2 jade family PHD finger 2
LXN latexin
MAMLD1 mastermind-like domain containing 1
MAPT microtubule-associated protein tau
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTS neurotensin
ODC1 ornithine decarboxylase 1
PLA2G16 phospholipase A2, group XVI
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SOX2 SRY (sex determining region Y)-box 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TXNDC9 thioredoxin domain containing 9

decreased expression

Symbol Name
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AUTS2 autism susceptibility candidate 2
BEX1 brain expressed, X-linked 1
BHLHE40 basic helix-loop-helix family, member e40
CD24 CD24 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLCA1 chloride channel accessory 1
CLU clusterin
DACH1 dachshund family transcription factor 1
DIO2 deiodinase, iodothyronine, type II
DKK3 dickkopf WNT signaling pathway inhibitor 3
ENO1 enolase 1, (alpha)
F3 coagulation factor III (thromboplastin, tissue factor)
FAM198B family with sequence similarity 198, member B
FCGBP Fc fragment of IgG binding protein
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GPM6A glycoprotein M6A
HBB hemoglobin, beta
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IGHD immunoglobulin heavy constant delta
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
LMO4 LIM domain only 4
MEIS2 Meis homeobox 2
MMP12 matrix metallopeptidase 12
PDIA3 protein disulfide isomerase family A, member 3
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLS3 plastin 3
RNF167 ring finger protein 167
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SNX7 sorting nexin 7
SPARCL1 SPARC-like 1 (hevin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TLR4 toll-like receptor 4
TSPAN5 tetraspanin 5