BRD-K29143967_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

184 genes differentially expressed following the BRD-K29143967_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABLIM1 actin binding LIM protein 1
ACSL1 acyl-CoA synthetase long-chain family member 1
ADIPOQ adiponectin, C1Q and collagen domain containing
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BASP1 brain abundant, membrane attached signal protein 1
BEX1 brain expressed, X-linked 1
BMP2 bone morphogenetic protein 2
CA12 carbonic anhydrase XII
CAPG capping protein (actin filament), gelsolin-like
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD163 CD163 molecule
CDC25B cell division cycle 25B
CFD complement factor D (adipsin)
CKB creatine kinase, brain
CLCN3 chloride channel, voltage-sensitive 3
CLMN calmin (calponin-like, transmembrane)
CLTB clathrin, light chain B
CTSB cathepsin B
DDAH2 dimethylarginine dimethylaminohydrolase 2
DDIT4 DNA-damage-inducible transcript 4
DUSP5 dual specificity phosphatase 5
EGFR epidermal growth factor receptor
EHBP1 EH domain binding protein 1
EMP1 epithelial membrane protein 1
ERBB4 erb-b2 receptor tyrosine kinase 4
EREG epiregulin
F12 coagulation factor XII (Hageman factor)
FBN2 fibrillin 2
FBXL12 F-box and leucine-rich repeat protein 12
FCGBP Fc fragment of IgG binding protein
FLOT1 flotillin 1
FOSL2 FOS-like antigen 2
G6PD glucose-6-phosphate dehydrogenase
HK2 hexokinase 2
HOOK2 hook microtubule-tethering protein 2
IGF1R insulin-like growth factor 1 receptor
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ILF3 interleukin enhancer binding factor 3, 90kDa
IRS1 insulin receptor substrate 1
KANK1 KN motif and ankyrin repeat domains 1
KIAA1598
KLF4 Kruppel-like factor 4 (gut)
LDLR low density lipoprotein receptor
LMO3 LIM domain only 3 (rhombotin-like 2)
LYST lysosomal trafficking regulator
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MAST2 microtubule associated serine/threonine kinase 2
MT1H metallothionein 1H
MT1X metallothionein 1X
MTA1 metastasis associated 1
MTL5 metallothionein-like 5, testis-specific (tesmin)
MTMR11 myotubularin related protein 11
MTSS1 metastasis suppressor 1
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOF myoferlin
NAMPT nicotinamide phosphoribosyltransferase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NQO1 NAD(P)H dehydrogenase, quinone 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDLIM1 PDZ and LIM domain 1
PER1 period circadian clock 1
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHYH phytanoyl-CoA 2-hydroxylase
PILRB paired immunoglobin-like type 2 receptor beta
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PPAP2C phosphatidic acid phosphatase type 2C
RAB4A RAB4A, member RAS oncogene family
RBPMS RNA binding protein with multiple splicing
RHOB ras homolog family member B
RNASE4 ribonuclease, RNase A family, 4
RRBP1 ribosome binding protein 1
S100A14 S100 calcium binding protein A14
S100P S100 calcium binding protein P
SATB2 SATB homeobox 2
SDC4 syndecan 4
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SIK1 salt-inducible kinase 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQLE squalene epoxidase
SRPX sushi-repeat containing protein, X-linked
SVIL supervillin
TBL1X transducin (beta)-like 1X-linked
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKT transketolase
TKTL1 transketolase-like 1
TRIB3 tribbles pseudokinase 3
TRIM16 tripartite motif containing 16
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
ACTA2 actin, alpha 2, smooth muscle, aorta
ADA adenosine deaminase
ADGRG2 adhesion G protein-coupled receptor G2
BIRC3 baculoviral IAP repeat containing 3
C6ORF62 chromosome 6 open reading frame 62
CADM1 cell adhesion molecule 1
CALB1 calbindin 1, 28kDa
CD99 CD99 molecule
CDC25A cell division cycle 25A
CEMIP cell migration inducing protein, hyaluronan binding
CLDN10 claudin 10
CLEC2B C-type lectin domain family 2, member B
COL1A1 collagen, type I, alpha 1
COL6A1 collagen, type VI, alpha 1
CXCL6 chemokine (C-X-C motif) ligand 6
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNM1L dynamin 1-like
DPP4 dipeptidyl-peptidase 4
FASTKD5 FAST kinase domains 5
FBN1 fibrillin 1
FBXO11 F-box protein 11
GJA1 gap junction protein, alpha 1, 43kDa
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPM6B glycoprotein M6B
GPX7 glutathione peroxidase 7
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HAPLN1 hyaluronan and proteoglycan link protein 1
HIST1H2BG histone cluster 1, H2bg
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOXA5 homeobox A5
HOXC6 homeobox C6
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA8 heat shock 70kDa protein 8
HSPB11 heat shock protein family B (small), member 11
HSPH1 heat shock 105kDa/110kDa protein 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
KCTD12 potassium channel tetramerization domain containing 12
KRT23 keratin 23, type I
MDK midkine (neurite growth-promoting factor 2)
MGP matrix Gla protein
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MPO myeloperoxidase
MTF2 metal response element binding transcription factor 2
NDUFA4 NDUFA4, mitochondrial complex associated
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NPTX2 neuronal pentraxin II
PELI1 pellino E3 ubiquitin protein ligase 1
PENK proenkephalin
PNPLA4 patatin-like phospholipase domain containing 4
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RELN reelin
RGS4 regulator of G-protein signaling 4
RNASET2 ribonuclease T2
RPA3 replication protein A3, 14kDa
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RRM2 ribonucleotide reductase M2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFPQ splicing factor proline/glutamine-rich
SFRP4 secreted frizzled-related protein 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SRGN serglycin
SULF1 sulfatase 1
TARP TCR gamma alternate reading frame protein
THY1 Thy-1 cell surface antigen
THYN1 thymocyte nuclear protein 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
ZNF12 zinc finger protein 12
ZNF586 zinc finger protein 586