BRD-K28916077_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

104 genes differentially expressed following the BRD-K28916077_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA1 annexin A1
AREG amphiregulin
ATF3 activating transcription factor 3
BCL10 B-cell CLL/lymphoma 10
BHLHE40 basic helix-loop-helix family, member e40
C1QB complement component 1, q subcomponent, B chain
CAV2 caveolin 2
CD24 CD24 molecule
CD47 CD47 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHIC2 cysteine-rich hydrophobic domain 2
CSRP2 cysteine and glycine-rich protein 2
CTSL cathepsin L
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
FGFBP1 fibroblast growth factor binding protein 1
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GLS glutaminase
GPRC5A G protein-coupled receptor, class C, group 5, member A
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IL1R1 interleukin 1 receptor, type I
INHBA inhibin, beta A
INPP1 inositol polyphosphate-1-phosphatase
ISG20 interferon stimulated exonuclease gene 20kDa
JOSD1 Josephin domain containing 1
JUN jun proto-oncogene
JUND jun D proto-oncogene
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KLK10 kallikrein-related peptidase 10
KRT19 keratin 19, type I
KRT4 keratin 4, type II
LAMB3 laminin, beta 3
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MGLL monoglyceride lipase
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NAMPT nicotinamide phosphoribosyltransferase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
ODC1 ornithine decarboxylase 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PPARD peroxisome proliferator-activated receptor delta
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTHLH parathyroid hormone-like hormone
PTN pleiotrophin
RALGDS ral guanine nucleotide dissociation stimulator
RHOF ras homolog family member F (in filopodia)
RIOK3 RIO kinase 3
S100A2 S100 calcium binding protein A2
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SMAD3 SMAD family member 3
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SPRR1B small proline-rich protein 1B
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SQLE squalene epoxidase
STK17A serine/threonine kinase 17a
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TUBB2A tubulin, beta 2A class IIa
TXNRD1 thioredoxin reductase 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UPP1 uridine phosphorylase 1
VNN1 vanin 1
ZFAND5 zinc finger, AN1-type domain 5
ZNF165 zinc finger protein 165

decreased expression

Symbol Name
BMP4 bone morphogenetic protein 4
C2CD5 C2 calcium-dependent domain containing 5
CCNF cyclin F
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
KIF20A kinesin family member 20A
MBOAT7 membrane bound O-acyltransferase domain containing 7
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
NT5DC2 5'-nucleotidase domain containing 2
PPAP2A phosphatidic acid phosphatase type 2A
PURA purine-rich element binding protein A
SEPHS1 selenophosphate synthetase 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10