BRD-K28907958_-666_SW620_6.0_h_11.1_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

132 genes differentially expressed following the BRD-K28907958_-666_SW620_6.0_h_11.1_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AIM2 absent in melanoma 2
APOD apolipoprotein D
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX1 armadillo repeat containing, X-linked 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BHLHE41 basic helix-loop-helix family, member e41
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
CBS cystathionine-beta-synthase
CCNG2 cyclin G2
CEP57 centrosomal protein 57kDa
CLIC4 chloride intracellular channel 4
COMP cartilage oligomeric matrix protein
CORO1A coronin, actin binding protein, 1A
CTH cystathionine gamma-lyase
CTSK cathepsin K
CX3CR1 chemokine (C-X3-C motif) receptor 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DOK5 docking protein 5
FAM134B family with sequence similarity 134, member B
FST follistatin
GAGE3 G antigen 3
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
HOXA5 homeobox A5
IGFBP5 insulin-like growth factor binding protein 5
IL32 interleukin 32
INHBE inhibin, beta E
INSIG1 insulin induced gene 1
JCHAIN joining chain of multimeric IgA and IgM
KLF9 Kruppel-like factor 9
KRT19 keratin 19, type I
MARS methionyl-tRNA synthetase
NNMT nicotinamide N-methyltransferase
NPTX2 neuronal pentraxin II
NRN1 neuritin 1
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
NUPR1 nuclear protein, transcriptional regulator, 1
OAT ornithine aminotransferase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4DIP phosphodiesterase 4D interacting protein
PHGDH phosphoglycerate dehydrogenase
RB1CC1 RB1-inducible coiled-coil 1
RHOQ ras homolog family member Q
SARS seryl-tRNA synthetase
SEPP1 selenoprotein P, plasma, 1
SH3BGR SH3 domain binding glutamate-rich protein
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNAI2 snail family zinc finger 2
SOD2 superoxide dismutase 2, mitochondrial
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
THBS2 thrombospondin 2
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
VSIG4 V-set and immunoglobulin domain containing 4
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
AURKA aurora kinase A
AXIN1 axin 1
B3GNT1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCND3 cyclin D3
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDCA4 cell division cycle associated 4
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CORO1C coronin, actin binding protein, 1C
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EIF4E eukaryotic translation initiation factor 4E
EPHB2 EPH receptor B2
FOXM1 forkhead box M1
H2AFX H2A histone family, member X
HIST1H2BG histone cluster 1, H2bg
HJURP Holliday junction recognition protein
HMGA2 high mobility group AT-hook 2
KAZN kazrin, periplakin interacting protein
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
LMO2 LIM domain only 2 (rhombotin-like 1)
MCM10 minichromosome maintenance complex component 10
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MSL1 male-specific lethal 1 homolog (Drosophila)
NCAPH non-SMC condensin I complex, subunit H
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NUP62 nucleoporin 62kDa
PDGFA platelet-derived growth factor alpha polypeptide
PDZD8 PDZ domain containing 8
PLBD1 phospholipase B domain containing 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRC1 protein regulator of cytokinesis 1
PTDSS1 phosphatidylserine synthase 1
PTTG1 pituitary tumor-transforming 1
RBP1 retinol binding protein 1, cellular
RGS4 regulator of G-protein signaling 4
RRP1B ribosomal RNA processing 1B
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SMC2 structural maintenance of chromosomes 2
TACC3 transforming, acidic coiled-coil containing protein 3
TPX2 TPX2, microtubule-associated
TTK TTK protein kinase
TUBB tubulin, beta class I
UBE2C ubiquitin-conjugating enzyme E2C