BRD-K28907958_-666_MCF7_6.0_h_11.1_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

151 genes differentially expressed following the BRD-K28907958_-666_MCF7_6.0_h_11.1_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDOC aldolase C, fructose-bisphosphate
ANXA4 annexin A4
ARL4C ADP-ribosylation factor-like 4C
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAX BCL2-associated X protein
BEX4 brain expressed, X-linked 4
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
BTG3 BTG family, member 3
CBS cystathionine-beta-synthase
CD52 CD52 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CPA3 carboxypeptidase A3 (mast cell)
CSTA cystatin A (stefin A)
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP1 dual specificity phosphatase 1
EPHA2 EPH receptor A2
FAS Fas cell surface death receptor
FBN2 fibrillin 2
FDXR ferredoxin reductase
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GRN granulin
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXA5 homeobox A5
HOXB2 homeobox B2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IL1R2 interleukin 1 receptor, type II
INSIG1 insulin induced gene 1
LGALS4 lectin, galactoside-binding, soluble, 4
MCL1 myeloid cell leukemia 1
MT1M metallothionein 1M
NNMT nicotinamide N-methyltransferase
OBSL1 obscurin-like 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAP prosaposin
PSAT1 phosphoserine aminotransferase 1
RAP1GAP RAP1 GTPase activating protein
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS2 regulator of G-protein signaling 2
SDC1 syndecan 1
SDC4 syndecan 4
SESN1 sestrin 1
SIK1 salt-inducible kinase 1
SKAP2 src kinase associated phosphoprotein 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
TRIM22 tripartite motif containing 22
TSC22D3 TSC22 domain family, member 3
VIM vimentin
ZBED2 zinc finger, BED-type containing 2
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C8ORF4 chromosome 8 open reading frame 4
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CDC20 cell division cycle 20
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CKS2 CDC28 protein kinase regulatory subunit 2
CNOT4 CCR4-NOT transcription complex, subunit 4
DEPDC1 DEP domain containing 1
DIO2 deiodinase, iodothyronine, type II
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DMD dystrophin
EIF4B eukaryotic translation initiation factor 4B
EPS8 epidermal growth factor receptor pathway substrate 8
FERMT2 fermitin family member 2
FGF13 fibroblast growth factor 13
FOXM1 forkhead box M1
GABPB1 GA binding protein transcription factor, beta subunit 1
GPSM2 G-protein signaling modulator 2
GRB14 growth factor receptor-bound protein 14
GREB1 growth regulation by estrogen in breast cancer 1
GTSE1 G-2 and S-phase expressed 1
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HSPA1A heat shock 70kDa protein 1A
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18A kinesin family member 18A
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LBR lamin B receptor
MKI67 marker of proliferation Ki-67
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NFIB nuclear factor I/B
NPY neuropeptide Y
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUSAP1 nucleolar and spindle associated protein 1
OLFM1 olfactomedin 1
PBK PDZ binding kinase
PDLIM5 PDZ and LIM domain 5
PDS5B PDS5 cohesin associated factor B
PLK1 polo-like kinase 1
PRC1 protein regulator of cytokinesis 1
PSRC1 proline/serine-rich coiled-coil 1
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RHOBTB3 Rho-related BTB domain containing 3
SHCBP1 SHC SH2-domain binding protein 1
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SPDEF SAM pointed domain containing ETS transcription factor
SPTBN1 spectrin, beta, non-erythrocytic 1
TACC3 transforming, acidic coiled-coil containing protein 3
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TROAP trophinin associated protein
TTK TTK protein kinase
TUBB4B tubulin, beta 4B class IVb
UBE2C ubiquitin-conjugating enzyme E2C
ZC3H4 zinc finger CCCH-type containing 4