BRD-K28907958_-666_HEPG2_6.0_h_11.1_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

92 genes differentially expressed following the BRD-K28907958_-666_HEPG2_6.0_h_11.1_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABLIM1 actin binding LIM protein 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BHLHE41 basic helix-loop-helix family, member e41
BTG2 BTG family, member 2
CCND2 cyclin D2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CLEC7A C-type lectin domain family 7, member A
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EGR3 early growth response 3
FAS Fas cell surface death receptor
GATA3 GATA binding protein 3
HBEGF heparin-binding EGF-like growth factor
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
IER3 immediate early response 3
IGF1 insulin-like growth factor 1 (somatomedin C)
INHBA inhibin, beta A
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LIF leukemia inhibitory factor
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NR4A2 nuclear receptor subfamily 4, group A, member 2
PDLIM3 PDZ and LIM domain 3
PLAT plasminogen activator, tissue
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TIGAR TP53 induced glycolysis regulatory phosphatase
TRBC1 T cell receptor beta constant 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
ANGPT1 angiopoietin 1
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CYTL1 cytokine-like 1
DCK deoxycytidine kinase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DIO1 deiodinase, iodothyronine, type I
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ERBB2 erb-b2 receptor tyrosine kinase 2
F13A1 coagulation factor XIII, A1 polypeptide
FAM111A family with sequence similarity 111, member A
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPX3 glutathione peroxidase 3
H2AFX H2A histone family, member X
HHEX hematopoietically expressed homeobox
HIST1H1C histone cluster 1, H1c
HMGB2 high mobility group box 2
HOXB7 homeobox B7
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KRT19 keratin 19, type I
LAPTM4B lysosomal protein transmembrane 4 beta
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
NYNRIN NYN domain and retroviral integrase containing
PLK1 polo-like kinase 1
PRC1 protein regulator of cytokinesis 1
RHOBTB3 Rho-related BTB domain containing 3
RPA1 replication protein A1, 70kDa
RRM2 ribonucleotide reductase M2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SORBS3 sorbin and SH3 domain containing 3
SORD sorbitol dehydrogenase
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TSPAN8 tetraspanin 8
UBE2C ubiquitin-conjugating enzyme E2C