BRD-K28453807_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-K28453807_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDOB aldolase B, fructose-bisphosphate
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA4 annexin A4
ARL4C ADP-ribosylation factor-like 4C
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CASP3 caspase 3, apoptosis-related cysteine peptidase
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CKLF chemokine-like factor
CLC Charcot-Leyden crystal galectin
COL1A2 collagen, type I, alpha 2
CPA3 carboxypeptidase A3 (mast cell)
CRIP2 cysteine-rich protein 2
CRISP3 cysteine-rich secretory protein 3
CXCR4 chemokine (C-X-C motif) receptor 4
DPYD dihydropyrimidine dehydrogenase
EVI2A ecotropic viral integration site 2A
EZR ezrin
FGFR3 fibroblast growth factor receptor 3
GJA1 gap junction protein, alpha 1, 43kDa
GPNMB glycoprotein (transmembrane) nmb
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL17RB interleukin 17 receptor B
KRT23 keratin 23, type I
LPAR6 lysophosphatidic acid receptor 6
MAN1A1 mannosidase, alpha, class 1A, member 1
MMP9 matrix metallopeptidase 9
MTSS1 metastasis suppressor 1
MXRA5 matrix-remodelling associated 5
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDLIM3 PDZ and LIM domain 3
PDZK1IP1 PDZK1 interacting protein 1
PEG10 paternally expressed 10
PLIN2 perilipin 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RGS1 regulator of G-protein signaling 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SDC2 syndecan 2
SNX7 sorting nexin 7
SPON2 spondin 2, extracellular matrix protein
SST somatostatin
SULF1 sulfatase 1
TCF4 transcription factor 4
TOX thymocyte selection-associated high mobility group box
TPD52 tumor protein D52
TRDV3 T cell receptor delta variable 3
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZIC1 Zic family member 1

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AGR2 anterior gradient 2
ALCAM activated leukocyte cell adhesion molecule
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
APOD apolipoprotein D
ASCL1 achaete-scute family bHLH transcription factor 1
C2CD2 C2 calcium-dependent domain containing 2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CST3 cystatin C
CSTA cystatin A (stefin A)
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
EBP emopamil binding protein (sterol isomerase)
FAM13A family with sequence similarity 13, member A
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GDF15 growth differentiation factor 15
GMDS GDP-mannose 4,6-dehydratase
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRN granulin
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LTBP3 latent transforming growth factor beta binding protein 3
MCOLN1 mucolipin 1
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
OXTR oxytocin receptor
PTGES prostaglandin E synthase
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SIDT2 SID1 transmembrane family, member 2
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRPX sushi-repeat containing protein, X-linked
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNC tenascin C
TSPAN8 tetraspanin 8
VCAN versican