BRD-K28366633_-666_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

210 genes differentially expressed following the BRD-K28366633_-666_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACAA2 acetyl-CoA acyltransferase 2
ADM adrenomedullin
AHCYL2 adenosylhomocysteinase-like 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BACE2 beta-site APP-cleaving enzyme 2
BAMBI BMP and activin membrane-bound inhibitor
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
CA2 carbonic anhydrase II
CBR1 carbonyl reductase 1
CBR3 carbonyl reductase 3
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COMP cartilage oligomeric matrix protein
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRYAB crystallin, alpha B
CTSL cathepsin L
CXCL6 chemokine (C-X-C motif) ligand 6
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DNASE1L3 deoxyribonuclease I-like 3
DSP desmoplakin
DUSP6 dual specificity phosphatase 6
EDNRB endothelin receptor type B
EFHD1 EF-hand domain family, member D1
ELN elastin
EMC3 ER membrane protein complex subunit 3
EPAS1 endothelial PAS domain protein 1
ERBB4 erb-b2 receptor tyrosine kinase 4
FABP4 fatty acid binding protein 4, adipocyte
FAM46A family with sequence similarity 46, member A
FHL1 four and a half LIM domains 1
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GLA galactosidase, alpha
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
GSN gelsolin
GSTP1 glutathione S-transferase pi 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFRD1 interferon-related developmental regulator 1
INHBA inhibin, beta A
INPP1 inositol polyphosphate-1-phosphatase
ITGB5 integrin, beta 5
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JCHAIN joining chain of multimeric IgA and IgM
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF5 Kruppel-like factor 5 (intestinal)
LGALS3 lectin, galactoside-binding, soluble, 3
LRP10 low density lipoprotein receptor-related protein 10
LYPD1 LY6/PLAUR domain containing 1
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MMP3 matrix metallopeptidase 3
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1M metallothionein 1M
MYO10 myosin X
NAMPT nicotinamide phosphoribosyltransferase
NCK2 NCK adaptor protein 2
NQO1 NAD(P)H dehydrogenase, quinone 1
NR0B1 nuclear receptor subfamily 0, group B, member 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEA15 phosphoprotein enriched in astrocytes 15
PIR pirin (iron-binding nuclear protein)
PPAP2B phosphatidic acid phosphatase type 2B
PRDX1 peroxiredoxin 1
PROM1 prominin 1
PSAP prosaposin
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
QKI QKI, KH domain containing, RNA binding
REG1B regenerating islet-derived 1 beta
RIOK3 RIO kinase 3
RRAGC Ras-related GTP binding C
S100A6 S100 calcium binding protein A6
S100P S100 calcium binding protein P
SASH1 SAM and SH3 domain containing 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCYL3 SCY1-like 3 (S. cerevisiae)
SDCBP syndecan binding protein (syntenin)
SFN stratifin
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SQSTM1 sequestosome 1
SST somatostatin
TM4SF1 transmembrane 4 L six family member 1
TMEM97 transmembrane protein 97
TNPO1 transportin 1
TSC22D3 TSC22 domain family, member 3
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
VNN1 vanin 1
WSB1 WD repeat and SOCS box containing 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACPP acid phosphatase, prostate
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AMD1 adenosylmethionine decarboxylase 1
ATAD2 ATPase family, AAA domain containing 2
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C1QBP complement component 1, q subcomponent binding protein
C3 complement component 3
C4BPA complement component 4 binding protein, alpha
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CFI complement factor I
CLGN calmegin
CRYM crystallin, mu
CTSH cathepsin H
DES desmin
DHCR24 24-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
DPP4 dipeptidyl-peptidase 4
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
F12 coagulation factor XII (Hageman factor)
FAM216A family with sequence similarity 216, member A
FASN fatty acid synthase
FBLN1 fibulin 1
FGG fibrinogen gamma chain
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOMER2 homer scaffolding protein 2
IFRD2 interferon-related developmental regulator 2
IPO5 importin 5
KIAA0101 KIAA0101
KLK11 kallikrein-related peptidase 11
KLK2 kallikrein-related peptidase 2
KLK3 kallikrein-related peptidase 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOC100505650 uncharacterized LOC100505650
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAGEA3 melanoma antigen family A3
MCAM melanoma cell adhesion molecule
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH10 myosin, heavy chain 10, non-muscle
NEFH neurofilament, heavy polypeptide
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NPY neuropeptide Y
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
NUP62 nucleoporin 62kDa
NUTF2 nuclear transport factor 2
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PCNA proliferating cell nuclear antigen
PCYOX1L prenylcysteine oxidase 1 like
PDZRN3 PDZ domain containing ring finger 3
PLCB4 phospholipase C, beta 4
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PPA2 pyrophosphatase (inorganic) 2
PRDX2 peroxiredoxin 2
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
PSPH phosphoserine phosphatase
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RGS10 regulator of G-protein signaling 10
RRAD Ras-related associated with diabetes
RUVBL1 RuvB-like AAA ATPase 1
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SF1 splicing factor 1
SFRP1 secreted frizzled-related protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SORD sorbitol dehydrogenase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPDEF SAM pointed domain containing ETS transcription factor
SRSF6 serine/arginine-rich splicing factor 6
ST7 suppression of tumorigenicity 7
STMN1 stathmin 1
TARBP1 TAR (HIV-1) RNA binding protein 1
TFPI2 tissue factor pathway inhibitor 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TPPP3 tubulin polymerization-promoting protein family member 3
TRIM14 tripartite motif containing 14
ZWINT ZW10 interacting kinetochore protein