BRD-K28366633_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

166 genes differentially expressed following the BRD-K28366633_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ACSM3 acyl-CoA synthetase medium-chain family member 3
ACTN1 actinin, alpha 1
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BTG1 B-cell translocation gene 1, anti-proliferative
CACYBP calcyclin binding protein
CBR3 carbonyl reductase 3
CRYAB crystallin, alpha B
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EIF1 eukaryotic translation initiation factor 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GATA6 GATA binding protein 6
GPX2 glutathione peroxidase 2
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HMOX1 heme oxygenase 1
HPSE heparanase
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGKV1-5 immunoglobulin kappa variable 1-5
IL1R2 interleukin 1 receptor, type II
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KLF6 Kruppel-like factor 6
KYNU kynureninase
LTF lactotransferrin
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MCL1 myeloid cell leukemia 1
MFSD10 major facilitator superfamily domain containing 10
MLF1 myeloid leukemia factor 1
MX1 MX dynamin-like GTPase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NEB nebulin
NFIL3 nuclear factor, interleukin 3 regulated
NPR3 natriuretic peptide receptor 3
NR0B1 nuclear receptor subfamily 0, group B, member 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4DIP phosphodiesterase 4D interacting protein
PDLIM1 PDZ and LIM domain 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIR pirin (iron-binding nuclear protein)
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKCQ protein kinase C, theta
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAMP1 receptor (G protein-coupled) activity modifying protein 1
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SCYL3 SCY1-like 3 (S. cerevisiae)
SFN stratifin
SIK1 salt-inducible kinase 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRR3 small proline-rich protein 3
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TARS threonyl-tRNA synthetase
TES testin LIM domain protein
TGFBI transforming growth factor, beta-induced, 68kDa
TRIB3 tribbles pseudokinase 3
TSPAN8 tetraspanin 8
TXNRD1 thioredoxin reductase 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
AIM1 absent in melanoma 1
AQP1 aquaporin 1 (Colton blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
C8ORF4 chromosome 8 open reading frame 4
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNE2 cyclin E2
CCNF cyclin F
CD36 CD36 molecule (thrombospondin receptor)
CDC25A cell division cycle 25A
CDK1 cyclin-dependent kinase 1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CX3CR1 chemokine (C-X3-C motif) receptor 1
DHCR24 24-dehydrocholesterol reductase
DICER1 dicer 1, ribonuclease type III
DPYD dihydropyrimidine dehydrogenase
ERBB3 erb-b2 receptor tyrosine kinase 3
FCGBP Fc fragment of IgG binding protein
GJA1 gap junction protein, alpha 1, 43kDa
GNAS GNAS complex locus
GOLT1B golgi transport 1B
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HOXA5 homeobox A5
HOXB2 homeobox B2
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
ITGAV integrin, alpha V
KCTD12 potassium channel tetramerization domain containing 12
LRRC17 leucine rich repeat containing 17
MACF1 microtubule-actin crosslinking factor 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MGP matrix Gla protein
MLEC malectin
MMP9 matrix metallopeptidase 9
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
PCNA proliferating cell nuclear antigen
PEG10 paternally expressed 10
PGAM1 phosphoglycerate mutase 1 (brain)
PIEZO2 piezo-type mechanosensitive ion channel component 2
PIP prolactin-induced protein
PRDX2 peroxiredoxin 2
PRR15L proline rich 15-like
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RGS5 regulator of G-protein signaling 5
RPS26 ribosomal protein S26
RRM2 ribonucleotide reductase M2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLE2 transducin-like enhancer of split 2
TNC tenascin C
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN12 tetraspanin 12
TUBB tubulin, beta class I
TYMS thymidylate synthetase
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
WFDC2 WAP four-disulfide core domain 2