BRD-K28366633_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

149 genes differentially expressed following the BRD-K28366633_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
C3ORF14 chromosome 3 open reading frame 14
CAPN2 calpain 2, (m/II) large subunit
CAV2 caveolin 2
CD163 CD163 molecule
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CFD complement factor D (adipsin)
CHIC2 cysteine-rich hydrophobic domain 2
CNOT4 CCR4-NOT transcription complex, subunit 4
CREB3L2 cAMP responsive element binding protein 3-like 2
CSTA cystatin A (stefin A)
CYTIP cytohesin 1 interacting protein
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSC2 desmocollin 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FAM129A family with sequence similarity 129, member A
FLRT2 fibronectin leucine rich transmembrane protein 2
FOSL1 FOS-like antigen 1
GATA6 GATA binding protein 6
GATAD1 GATA zinc finger domain containing 1
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFI16 interferon, gamma-inducible protein 16
IGFBP5 insulin-like growth factor binding protein 5
IL10RA interleukin 10 receptor, alpha
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KRT13 keratin 13, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KYNU kynureninase
LY96 lymphocyte antigen 96
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCH1 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
MBNL2 muscleblind-like splicing regulator 2
MDFIC MyoD family inhibitor domain containing
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MT1M metallothionein 1M
NAMPT nicotinamide phosphoribosyltransferase
NMRK1 nicotinamide riboside kinase 1
NPTX2 neuronal pentraxin II
NR0B1 nuclear receptor subfamily 0, group B, member 1
OPN3 opsin 3
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX3 pre-B-cell leukemia homeobox 3
PDGFC platelet derived growth factor C
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEA15 phosphoprotein enriched in astrocytes 15
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKP1 plakophilin 1
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
S100A14 S100 calcium binding protein A14
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERTAD2 SERTA domain containing 2
SFN stratifin
SFTPB surfactant protein B
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPRR3 small proline-rich protein 3
STAR steroidogenic acute regulatory protein
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFA transforming growth factor, alpha
TPK1 thiamin pyrophosphokinase 1
TRDV3 T cell receptor delta variable 3
TTN titin
UPP1 uridine phosphorylase 1
VWF von Willebrand factor
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
AURKA aurora kinase A
BTBD3 BTB (POZ) domain containing 3
CCND1 cyclin D1
CCNF cyclin F
CDK1 cyclin-dependent kinase 1
CDR2L cerebellar degeneration-related protein 2-like
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CXCL9 chemokine (C-X-C motif) ligand 9
DACH1 dachshund family transcription factor 1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM57A family with sequence similarity 57, member A
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSTM3 glutathione S-transferase mu 3 (brain)
HLA-B major histocompatibility complex, class I, B
HLA-F major histocompatibility complex, class I, F
HLTF helicase-like transcription factor
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
IL6ST interleukin 6 signal transducer
KANK1 KN motif and ankyrin repeat domains 1
KANK2 KN motif and ankyrin repeat domains 2
KIF2C kinesin family member 2C
LAMC1 laminin, gamma 1 (formerly LAMB2)
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MARCKSL1 MARCKS-like 1
MGLL monoglyceride lipase
MLEC malectin
MMP9 matrix metallopeptidase 9
MSH6 mutS homolog 6
NR2F1 nuclear receptor subfamily 2, group F, member 1
NREP neuronal regeneration related protein
PCCB propionyl CoA carboxylase, beta polypeptide
PCGF2 polycomb group ring finger 2
PCNA proliferating cell nuclear antigen
PDHB pyruvate dehydrogenase (lipoamide) beta
PEBP1 phosphatidylethanolamine binding protein 1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
POGLUT1 protein O-glucosyltransferase 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTCH1 patched 1
RBP4 retinol binding protein 4, plasma
RELN reelin
RPS11 ribosomal protein S11
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SOX4 SRY (sex determining region Y)-box 4
TBC1D16 TBC1 domain family, member 16
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TNS3 tensin 3
TUBB tubulin, beta class I
TXNDC9 thioredoxin domain containing 9