BRD-K28366633_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

175 genes differentially expressed following the BRD-K28366633_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BCL6 B-cell CLL/lymphoma 6
C5AR1 complement component 5a receptor 1
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CAPN2 calpain 2, (m/II) large subunit
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLEC11A C-type lectin domain family 11, member A
COL11A1 collagen, type XI, alpha 1
CPM carboxypeptidase M
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP6 dual specificity phosphatase 6
EFNB2 ephrin-B2
EPAS1 endothelial PAS domain protein 1
EPCAM epithelial cell adhesion molecule
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLC glutamate-cysteine ligase, catalytic subunit
GDF15 growth differentiation factor 15
HIST1H2BG histone cluster 1, H2bg
HPCAL1 hippocalcin-like 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IRS2 insulin receptor substrate 2
ITM2A integral membrane protein 2A
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LPAR2 lysophosphatidic acid receptor 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOB monoamine oxidase B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MBNL2 muscleblind-like splicing regulator 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGAM maltase-glucoamylase
MMP1 matrix metallopeptidase 1
MMP7 matrix metallopeptidase 7
MT1M metallothionein 1M
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NEFL neurofilament, light polypeptide
NELL2 NEL-like 2 (chicken)
NFIL3 nuclear factor, interleukin 3 regulated
NPTX2 neuronal pentraxin II
NR0B1 nuclear receptor subfamily 0, group B, member 1
NUPR1 nuclear protein, transcriptional regulator, 1
ODC1 ornithine decarboxylase 1
OPN3 opsin 3
P3H2 prolyl 3-hydroxylase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHGDH phosphoglycerate dehydrogenase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNKP polynucleotide kinase 3'-phosphatase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RRAD Ras-related associated with diabetes
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORBS2 sorbin and SH3 domain containing 2
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPP1 secreted phosphoprotein 1
SRGN serglycin
STC2 stanniocalcin 2
TGFA transforming growth factor, alpha
TRD T cell receptor delta locus
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WIF1 WNT inhibitory factor 1
XPOT exportin, tRNA

decreased expression

Symbol Name
AURKA aurora kinase A
C8ORF4 chromosome 8 open reading frame 4
CBR3 carbonyl reductase 3
CD59 CD59 molecule, complement regulatory protein
CDA cytidine deaminase
CDC25B cell division cycle 25B
CDK1 cyclin-dependent kinase 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPA centromere protein A
CPNE3 copine III
EMP2 epithelial membrane protein 2
EPS8L2 EPS8-like 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FZD7 frizzled class receptor 7
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GOLGA8A golgin A8 family, member A
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HOXA10 homeobox A10
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP4 insulin-like growth factor binding protein 4
KDM4B lysine (K)-specific demethylase 4B
KIF2C kinesin family member 2C
KLHL9 kelch-like family member 9
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LASP1 LIM and SH3 protein 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MGLL monoglyceride lipase
NISCH nischarin
PLK1 polo-like kinase 1
PLS3 plastin 3
PSCA prostate stem cell antigen
PTCH1 patched 1
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SEPP1 selenoprotein P, plasma, 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRRM2 serine/arginine repetitive matrix 2
SUB1 SUB1 homolog (S. cerevisiae)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBC1D2B TBC1 domain family, member 2B
TMPRSS4 transmembrane protease, serine 4
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM14 tripartite motif containing 14
TRIM29 tripartite motif containing 29
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
UBE2C ubiquitin-conjugating enzyme E2C
WEE1 WEE1 G2 checkpoint kinase
ZNF185 zinc finger protein 185 (LIM domain)
ZW10 zw10 kinetochore protein