BRD-K28366633_-666_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

116 genes differentially expressed following the BRD-K28366633_-666_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
CADM1 cell adhesion molecule 1
CALCOCO2 calcium binding and coiled-coil domain 2
CASP7 caspase 7, apoptosis-related cysteine peptidase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD69 CD69 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COBL cordon-bleu WH2 repeat protein
CRYAB crystallin, alpha B
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DMD dystrophin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
EAPP E2F-associated phosphoprotein
ELF5 E74-like factor 5 (ets domain transcription factor)
GAREM GRB2 associated, regulator of MAPK1
GARS glycyl-tRNA synthetase
GATA3 GATA binding protein 3
GPER1 G protein-coupled estrogen receptor 1
GRB10 growth factor receptor-bound protein 10
HEPH hephaestin
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGL immunoglobulin lambda locus
IL1R2 interleukin 1 receptor, type II
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
ITM2A integral membrane protein 2A
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
LHFPL2 lipoma HMGIC fusion partner-like 2
LYST lysosomal trafficking regulator
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP7 microtubule-associated protein 7
MT1M metallothionein 1M
MYO1B myosin IB
NFIL3 nuclear factor, interleukin 3 regulated
NMRK1 nicotinamide riboside kinase 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4DIP phosphodiesterase 4D interacting protein
PELI1 pellino E3 ubiquitin protein ligase 1
PLS3 plastin 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMP22 peripheral myelin protein 22
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PROM1 prominin 1
S100P S100 calcium binding protein P
SH3YL1 SH3 and SYLF domain containing 1
SIK1 salt-inducible kinase 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SORBS2 sorbin and SH3 domain containing 2
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
TBX3 T-box 3
TFF3 trefoil factor 3 (intestinal)
TPD52 tumor protein D52
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
XBP1 X-box binding protein 1
XPOT exportin, tRNA
XYLT1 xylosyltransferase I

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND1 cyclin D1
CD24 CD24 molecule
CDC20 cell division cycle 20
CFI complement factor I
CKB creatine kinase, brain
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
F2R coagulation factor II (thrombin) receptor
HN1 hematological and neurological expressed 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT4 keratin 4, type II
LRRC17 leucine rich repeat containing 17
MARCKS myristoylated alanine-rich protein kinase C substrate
MEIS2 Meis homeobox 2
NPY neuropeptide Y
NRIP1 nuclear receptor interacting protein 1
NUP85 nucleoporin 85kDa
PEG10 paternally expressed 10
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RPL10 ribosomal protein L10
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPT2 septin 2
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SST somatostatin
TFPI2 tissue factor pathway inhibitor 2
TIMP1 TIMP metallopeptidase inhibitor 1
WT1 Wilms tumor 1