BRD-K28296557_Akt inhibitor IV_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

119 genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AEBP1 AE binding protein 1
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BGN biglycan
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CCL8 chemokine (C-C motif) ligand 8
CD14 CD14 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EDNRA endothelin receptor type A
EIF1 eukaryotic translation initiation factor 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G0S2 G0/G1 switch 2
G6PD glucose-6-phosphate dehydrogenase
GADD45B growth arrest and DNA-damage-inducible, beta
GLUL glutamate-ammonia ligase
HES1 hes family bHLH transcription factor 1
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM1 intercellular adhesion molecule 1
IER5 immediate early response 5
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCTD12 potassium channel tetramerization domain containing 12
KLF6 Kruppel-like factor 6
LDLR low density lipoprotein receptor
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MGP matrix Gla protein
NAMPT nicotinamide phosphoribosyltransferase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUPR1 nuclear protein, transcriptional regulator, 1
PCSK5 proprotein convertase subtilisin/kexin type 5
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMEPA1 prostate transmembrane protein, androgen induced 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRELP proline/arginine-rich end leucine-rich repeat protein
RBM47 RNA binding motif protein 47
RBMS1 RNA binding motif, single stranded interacting protein 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RYBP RING1 and YY1 binding protein
S100A8 S100 calcium binding protein A8
SCYL3 SCY1-like 3 (S. cerevisiae)
SFRP4 secreted frizzled-related protein 4
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOX4 SRY (sex determining region Y)-box 4
SULF1 sulfatase 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSPYL5 TSPY-like 5
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ADA adenosine deaminase
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CBR3 carbonyl reductase 3
CCNE2 cyclin E2
CCR7 chemokine (C-C motif) receptor 7
CDC25A cell division cycle 25A
CIRBP cold inducible RNA binding protein
FUBP1 far upstream element (FUSE) binding protein 1
GATA3 GATA binding protein 3
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GJA1 gap junction protein, alpha 1, 43kDa
HHEX hematopoietically expressed homeobox
HNRNPL heterogeneous nuclear ribonucleoprotein L
ITGA6 integrin, alpha 6
LYPD3 LY6/PLAUR domain containing 3
MAT2A methionine adenosyltransferase II, alpha
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDRG2 NDRG family member 2
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
NTS neurotensin
OLFM1 olfactomedin 1
PNISR PNN-interacting serine/arginine-rich protein
PTCH1 patched 1
RRM2 ribonucleotide reductase M2
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SESN1 sestrin 1
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
TARDBP TAR DNA binding protein
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TRIB1 tribbles pseudokinase 1
TUBB6 tubulin, beta 6 class V