BRD-K28296557_Akt inhibitor IV_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

228 genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACTA1 actin, alpha 1, skeletal muscle
ADM adrenomedullin
AIM2 absent in melanoma 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALB albumin
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF3 activating transcription factor 3
ATXN1 ataxin 1
BTG1 B-cell translocation gene 1, anti-proliferative
C5 complement component 5
C6ORF48 chromosome 6 open reading frame 48
CA2 carbonic anhydrase II
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPG capping protein (actin filament), gelsolin-like
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCPG1 cell cycle progression 1
CD36 CD36 molecule (thrombospondin receptor)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CLIC4 chloride intracellular channel 4
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
CPD carboxypeptidase D
CREB3L2 cAMP responsive element binding protein 3-like 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPAS1 endothelial PAS domain protein 1
EPRS glutamyl-prolyl-tRNA synthetase
FAM129A family with sequence similarity 129, member A
FBLN2 fibulin 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGG fibrinogen gamma chain
FHL1 four and a half LIM domains 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GAS1 growth arrest-specific 1
GATA6 GATA binding protein 6
GPNMB glycoprotein (transmembrane) nmb
GRB10 growth factor receptor-bound protein 10
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
INHBB inhibin, beta B
INHBE inhibin, beta E
ISG20 interferon stimulated exonuclease gene 20kDa
JCHAIN joining chain of multimeric IgA and IgM
KLF4 Kruppel-like factor 4 (gut)
KRT17 keratin 17, type I
KRT23 keratin 23, type I
LAMP3 lysosomal-associated membrane protein 3
LARP6 La ribonucleoprotein domain family, member 6
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARS methionyl-tRNA synthetase
MFAP5 microfibrillar associated protein 5
MICALL1 MICAL-like 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC5B mucin 5B, oligomeric mucus/gel-forming
NBPF10 neuroblastoma breakpoint family, member 10
NEBL nebulette
NQO1 NAD(P)H dehydrogenase, quinone 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
PAWR PRKC, apoptosis, WT1, regulator
PBX1 pre-B-cell leukemia homeobox 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4DIP phosphodiesterase 4D interacting protein
PPAP2B phosphatidic acid phosphatase type 2B
PROM1 prominin 1
PSAT1 phosphoserine aminotransferase 1
PTGIS prostaglandin I2 (prostacyclin) synthase
PXDC1 PX domain containing 1
RCAN1 regulator of calcineurin 1
RND3 Rho family GTPase 3
SARS seryl-tRNA synthetase
SCARB2 scavenger receptor class B, member 2
SERINC3 serine incorporator 3
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGR SH3 domain binding glutamate-rich protein
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINK1 serine peptidase inhibitor, Kazal type 1
STC2 stanniocalcin 2
SULF1 sulfatase 1
TCEA1 transcription elongation factor A (SII), 1
TF transferrin
TGFA transforming growth factor, alpha
TMEM45A transmembrane protein 45A
TMPRSS3 transmembrane protease, serine 3
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TNNC1 troponin C type 1 (slow)
TOX3 TOX high mobility group box family member 3
TPM1 tropomyosin 1 (alpha)
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UGP2 UDP-glucose pyrophosphorylase 2
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACOT7 acyl-CoA thioesterase 7
AHCY adenosylhomocysteinase
AMD1 adenosylmethionine decarboxylase 1
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
B3GNT1
BEX1 brain expressed, X-linked 1
BOP1 block of proliferation 1
BST2 bone marrow stromal cell antigen 2
C14ORF2 chromosome 14 open reading frame 2
C1QBP complement component 1, q subcomponent binding protein
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CD320 CD320 molecule
CD47 CD47 molecule
CDC45 cell division cycle 45
CHEK2 checkpoint kinase 2
CKS2 CDC28 protein kinase regulatory subunit 2
DCXR dicarbonyl/L-xylulose reductase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DHFR dihydrofolate reductase
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENDOD1 endonuclease domain containing 1
F12 coagulation factor XII (Hageman factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
FJX1 four jointed box 1 (Drosophila)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPX1 glutathione peroxidase 1
HIST1H2BK histone cluster 1, H2bk
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HN1L hematological and neurological expressed 1-like
HOMER2 homer scaffolding protein 2
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12
IGF1R insulin-like growth factor 1 receptor
INSIG1 insulin induced gene 1
KDM5D lysine (K)-specific demethylase 5D
KIF15 kinesin family member 15
KLK3 kallikrein-related peptidase 3
LDLR low density lipoprotein receptor
LIG1 ligase I, DNA, ATP-dependent
LY6E lymphocyte antigen 6 complex, locus E
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
MRPL12 mitochondrial ribosomal protein L12
MRPL20 mitochondrial ribosomal protein L20
MRPS30 mitochondrial ribosomal protein S30
MSMO1 methylsterol monooxygenase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCBP MYC binding protein
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPH non-SMC condensin I complex, subunit H
NEFH neurofilament, heavy polypeptide
NME1 NME/NM23 nucleoside diphosphate kinase 1
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
OLFM1 olfactomedin 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PCCB propionyl CoA carboxylase, beta polypeptide
PCNA proliferating cell nuclear antigen
PFKL phosphofructokinase, liver
PLAT plasminogen activator, tissue
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPIF peptidylprolyl isomerase F
QDPR quinoid dihydropteridine reductase
RALGDS ral guanine nucleotide dissociation stimulator
RRM2 ribonucleotide reductase M2
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLIRP SRA stem-loop interacting RNA binding protein
SMS spermine synthase
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SORD sorbitol dehydrogenase
STK39 serine threonine kinase 39
STMN1 stathmin 1
TK1 thymidine kinase 1, soluble
TMEM164 transmembrane protein 164
TRIP13 thyroid hormone receptor interactor 13
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TXN thioredoxin
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase