BRD-K28296557_Akt inhibitor IV_TYKNU_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

159 genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_TYKNU_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATF3 activating transcription factor 3
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BEX1 brain expressed, X-linked 1
BHLHE41 basic helix-loop-helix family, member e41
BST2 bone marrow stromal cell antigen 2
CAPG capping protein (actin filament), gelsolin-like
CAST calpastatin
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHGB chromogranin B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CNOT4 CCR4-NOT transcription complex, subunit 4
CRISP3 cysteine-rich secretory protein 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSRP1 cysteine and glycine-rich protein 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
EGR1 early growth response 1
EGR3 early growth response 3
EIF4A1 eukaryotic translation initiation factor 4A1
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GAS1 growth arrest-specific 1
GDF15 growth differentiation factor 15
GPM6B glycoprotein M6B
GPRC5A G protein-coupled receptor, class C, group 5, member A
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFRD1 interferon-related developmental regulator 1
ISG15 ISG15 ubiquitin-like modifier
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCTD12 potassium channel tetramerization domain containing 12
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KRT7 keratin 7, type II
KRT81 keratin 81, type II
L1CAM L1 cell adhesion molecule
LGALS3 lectin, galactoside-binding, soluble, 3
MAMLD1 mastermind-like domain containing 1
MCL1 myeloid cell leukemia 1
MFSD10 major facilitator superfamily domain containing 10
MKRN1 makorin ring finger protein 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1HL1 metallothionein 1H-like 1
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PCOLCE2 procollagen C-endopeptidase enhancer 2
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PITX1 paired-like homeodomain 1
PKM pyruvate kinase, muscle
PODXL podocalyxin-like
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSCA prostate stem cell antigen
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNASE3 ribonuclease, RNase A family, 3
RNF167 ring finger protein 167
RRAGD Ras-related GTP binding D
RSAD2 radical S-adenosyl methionine domain containing 2
SELL selectin L
SFRP4 secreted frizzled-related protein 4
SPATS2L spermatogenesis associated, serine-rich 2-like
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRRM2 serine/arginine repetitive matrix 2
SRSF7 serine/arginine-rich splicing factor 7
STX1A syntaxin 1A (brain)
TMEM255A transmembrane protein 255A
UGDH UDP-glucose 6-dehydrogenase
VAMP8 vesicle-associated membrane protein 8
ZNF586 zinc finger protein 586
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADAM9 ADAM metallopeptidase domain 9
AKR1C3 aldo-keto reductase family 1, member C3
ASPH aspartate beta-hydroxylase
ATP13A3 ATPase type 13A3
AUTS2 autism susceptibility candidate 2
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CALML3 calmodulin-like 3
CCND2 cyclin D2
CEMIP cell migration inducing protein, hyaluronan binding
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL4A1 collagen, type IV, alpha 1
COL4A5 collagen, type IV, alpha 5
CPNE3 copine III
CUL5 cullin 5
DICER1 dicer 1, ribonuclease type III
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FGFR1OP FGFR1 oncogene partner
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GCLC glutamate-cysteine ligase, catalytic subunit
GLUL glutamate-ammonia ligase
HACD3 3-hydroxyacyl-CoA dehydratase 3
IER3 immediate early response 3
IFNGR1 interferon gamma receptor 1
IL1R2 interleukin 1 receptor, type II
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
MAGEA3 melanoma antigen family A3
MAGED1 melanoma antigen family D1
MAN1A1 mannosidase, alpha, class 1A, member 1
MPZL2 myelin protein zero-like 2
MTSS1 metastasis suppressor 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NTS neurotensin
OSBPL8 oxysterol binding protein-like 8
P3H2 prolyl 3-hydroxylase 2
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCB protein kinase C, beta
PRKX protein kinase, X-linked
PTPRE protein tyrosine phosphatase, receptor type, E
RGS5 regulator of G-protein signaling 5
SEPP1 selenoprotein P, plasma, 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
SOD2 superoxide dismutase 2, mitochondrial
TCF4 transcription factor 4
TXNL4B thioredoxin-like 4B
VCAN versican
VSNL1 visinin-like 1
WSB2 WD repeat and SOCS box containing 2