BRD-K28296557_Akt inhibitor IV_THP1_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

326 genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_THP1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACPP acid phosphatase, prostate
ADGRF5 adhesion G protein-coupled receptor F5
ADGRG1 adhesion G protein-coupled receptor G1
ADIRF adipogenesis regulatory factor
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX15B arachidonate 15-lipoxygenase, type B
AMIGO2 adhesion molecule with Ig-like domain 2
ANGPT2 angiopoietin 2
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARG2 arginase 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
AUTS2 autism susceptibility candidate 2
BCAM basal cell adhesion molecule (Lutheran blood group)
BLNK B-cell linker
BMP4 bone morphogenetic protein 4
BPHL biphenyl hydrolase-like (serine hydrolase)
C10ORF10 chromosome 10 open reading frame 10
CA4 carbonic anhydrase IV
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAST calpastatin
CCL2 chemokine (C-C motif) ligand 2
CD24 CD24 molecule
CD38 CD38 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CFB complement factor B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHN1 chimerin 1
COG7 component of oligomeric golgi complex 7
COL1A2 collagen, type I, alpha 2
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CTNND1 catenin (cadherin-associated protein), delta 1
DACH1 dachshund family transcription factor 1
DENND1B DENN/MADD domain containing 1B
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
DOCK4 dedicator of cytokinesis 4
DPP4 dipeptidyl-peptidase 4
EDN1 endothelin 1
EDNRA endothelin receptor type A
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPAS1 endothelial PAS domain protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM69A family with sequence similarity 69, member A
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FILIP1L filamin A interacting protein 1-like
FLOT1 flotillin 1
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
FRZB frizzled-related protein
FXYD6 FXYD domain containing ion transport regulator 6
FZD5 frizzled class receptor 5
GAGE3 G antigen 3
GAS6 growth arrest-specific 6
GDF15 growth differentiation factor 15
GJA1 gap junction protein, alpha 1, 43kDa
GREM1 gremlin 1, DAN family BMP antagonist
GUSBP11 glucuronidase, beta pseudogene 11
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H3H histone cluster 1, H3h
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IFI27 interferon, alpha-inducible protein 27
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL13RA1 interleukin 13 receptor, alpha 1
IL7R interleukin 7 receptor
IPO13 importin 13
ISYNA1 inositol-3-phosphate synthase 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITM2C integral membrane protein 2C
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
JUP junction plakoglobin
KLHDC2 kelch domain containing 2
LDOC1 leucine zipper, down-regulated in cancer 1
LEFTY1 left-right determination factor 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LPAR6 lysophosphatidic acid receptor 6
LRMP lymphoid-restricted membrane protein
LYPD1 LY6/PLAUR domain containing 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MAP3K7CL MAP3K7 C-terminal like
MDK midkine (neurite growth-promoting factor 2)
MECOM MDS1 and EVI1 complex locus
MEIS2 Meis homeobox 2
MEST mesoderm specific transcript
MME membrane metallo-endopeptidase
MSLN mesothelin
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NAT8 N-acetyltransferase 8 (GCN5-related, putative)
NCKAP1 NCK-associated protein 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NELL2 NEL-like 2 (chicken)
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NPTX2 neuronal pentraxin II
NR2F1 nuclear receptor subfamily 2, group F, member 1
NT5E 5'-nucleotidase, ecto (CD73)
NUAK1 NUAK family, SNF1-like kinase, 1
OLFM4 olfactomedin 4
OSBPL10 oxysterol binding protein-like 10
P3H2 prolyl 3-hydroxylase 2
PARM1 prostate androgen-regulated mucin-like protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE9A phosphodiesterase 9A
PDGFD platelet derived growth factor D
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDPN podoplanin
PEG10 paternally expressed 10
PELI1 pellino E3 ubiquitin protein ligase 1
PGAP1 post-GPI attachment to proteins 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLVAP plasmalemma vesicle associated protein
POSTN periostin, osteoblast specific factor
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKCI protein kinase C, iota
PRUNE2 prune homolog 2 (Drosophila)
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTK2 protein tyrosine kinase 2
PTN pleiotrophin
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTPRK protein tyrosine phosphatase, receptor type, K
PTPRO protein tyrosine phosphatase, receptor type, O
PXN paxillin
RAB21 RAB21, member RAS oncogene family
RAI14 retinoic acid induced 14
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
RLN1 relaxin 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RTN1 reticulon 1
RYBP RING1 and YY1 binding protein
SCGB1D2 secretoglobin, family 1D, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC1 syndecan 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SHB Src homology 2 domain containing adaptor protein B
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SNX13 sorting nexin 13
SNX7 sorting nexin 7
SOX13 SRY (sex determining region Y)-box 13
SPATA7 spermatogenesis associated 7
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SSPN sarcospan
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STON1 stonin 1
SULF1 sulfatase 1
TACC2 transforming, acidic coiled-coil containing protein 2
TBXA2R thromboxane A2 receptor
TCEAL2 transcription elongation factor A (SII)-like 2
TDP2 tyrosyl-DNA phosphodiesterase 2
TEK TEK tyrosine kinase, endothelial
TES testin LIM domain protein
TESK1 testis-specific kinase 1
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM176A transmembrane protein 176A
TMEM30B transmembrane protein 30B
TMSB15A thymosin beta 15a
TOX thymocyte selection-associated high mobility group box
TRDV3 T cell receptor delta variable 3
TREM2 triggering receptor expressed on myeloid cells 2
TRIB2 tribbles pseudokinase 2
TRIM2 tripartite motif containing 2
TSPAN12 tetraspanin 12
VEGFA vascular endothelial growth factor A
XCL1 chemokine (C motif) ligand 1
ZNF204P zinc finger protein 204, pseudogene
ZNF331 zinc finger protein 331
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACACA acetyl-CoA carboxylase alpha
ACAT1 acetyl-CoA acetyltransferase 1
ACSL1 acyl-CoA synthetase long-chain family member 1
AFG3L2 AFG3-like AAA ATPase 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AK1 adenylate kinase 1
ALCAM activated leukocyte cell adhesion molecule
ANXA5 annexin A5
ANXA6 annexin A6
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ARFIP2 ADP-ribosylation factor interacting protein 2
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASCC3 activating signal cointegrator 1 complex subunit 3
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BMI1 BMI1 proto-oncogene, polycomb ring finger
CCNE2 cyclin E2
CD151 CD151 molecule (Raph blood group)
CD36 CD36 molecule (thrombospondin receptor)
CDC123 cell division cycle 123
CHPT1 choline phosphotransferase 1
COBL cordon-bleu WH2 repeat protein
CPVL carboxypeptidase, vitellogenic-like
CRIP1 cysteine-rich protein 1 (intestinal)
CTR9 CTR9, Paf1/RNA polymerase II complex component
CTSG cathepsin G
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
CYFIP1 cytoplasmic FMR1 interacting protein 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
FAM98A family with sequence similarity 98, member A
FLT3 fms-related tyrosine kinase 3
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GAS7 growth arrest-specific 7
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GOLM1 golgi membrane protein 1
GRWD1 glutamate-rich WD repeat containing 1
HN1L hematological and neurological expressed 1-like
HOXC6 homeobox C6
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ICMT isoprenylcysteine carboxyl methyltransferase
IQGAP2 IQ motif containing GTPase activating protein 2
KAZN kazrin, periplakin interacting protein
KIF5B kinesin family member 5B
KLC1 kinesin light chain 1
KLF4 Kruppel-like factor 4 (gut)
KRT10 keratin 10, type I
LPL lipoprotein lipase
LTF lactotransferrin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAPK6 mitogen-activated protein kinase 6
MARCKSL1 MARCKS-like 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MED1 mediator complex subunit 1
MGST2 microsomal glutathione S-transferase 2
MRPL23 mitochondrial ribosomal protein L23
MSRB2 methionine sulfoxide reductase B2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOTCH2 notch 2
NUP210 nucleoporin 210kDa
NUP98 nucleoporin 98kDa
PDLIM2 PDZ and LIM domain 2 (mystique)
PGRMC1 progesterone receptor membrane component 1
PHYH phytanoyl-CoA 2-hydroxylase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAC8 placenta-specific 8
PLTP phospholipid transfer protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRMT1 protein arginine methyltransferase 1
PROM1 prominin 1
PTDSS1 phosphatidylserine synthase 1
QDPR quinoid dihydropteridine reductase
RAB4A RAB4A, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RFK riboflavin kinase
RPP38 ribonuclease P/MRP 38kDa subunit
RPS26 ribosomal protein S26
RPS27L ribosomal protein S27-like
RUNX1 runt-related transcription factor 1
SACS sacsin molecular chaperone
SASH3 SAM and SH3 domain containing 3
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC43A3 solute carrier family 43, member 3
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
SMCO4 single-pass membrane protein with coiled-coil domains 4
SORD sorbitol dehydrogenase
STOM stomatin
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMED3 transmembrane emp24 protein transport domain containing 3
TMEM5 transmembrane protein 5
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOP2B topoisomerase (DNA) II beta 180kDa
TRAF3IP3 TRAF3 interacting protein 3
TXNL4A thioredoxin-like 4A
UBE3C ubiquitin protein ligase E3C
UGCG UDP-glucose ceramide glucosyltransferase
ZBTB18 zinc finger and BTB domain containing 18
ZC3H13 zinc finger CCCH-type containing 13
ZNF106 zinc finger protein 106