BRD-K28296557_Akt inhibitor IV_SW620_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_SW620_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
ALDOB aldolase B, fructose-bisphosphate
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARID5B AT rich interactive domain 5B (MRF1-like)
ASPN asporin
ATF3 activating transcription factor 3
BEX4 brain expressed, X-linked 4
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CCL2 chemokine (C-C motif) ligand 2
CD9 CD9 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL11A1 collagen, type XI, alpha 1
CYR61 cysteine-rich, angiogenic inducer, 61
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT4 DNA-damage-inducible transcript 4
DDR1 discoidin domain receptor tyrosine kinase 1
DNM1L dynamin 1-like
DUSP1 dual specificity phosphatase 1
EFHD1 EF-hand domain family, member D1
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
EZR ezrin
F11R F11 receptor
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GAGE3 G antigen 3
GREM1 gremlin 1, DAN family BMP antagonist
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H4C histone cluster 1, H4c
HSPA1A heat shock 70kDa protein 1A
IER2 immediate early response 2
IGFBP5 insulin-like growth factor binding protein 5
IL13RA1 interleukin 13 receptor, alpha 1
IPO13 importin 13
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF9 Kruppel-like factor 9
KRT19 keratin 19, type I
LUM lumican
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN1A1 mannosidase, alpha, class 1A, member 1
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MYOF myoferlin
NR4A1 nuclear receptor subfamily 4, group A, member 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PERP PERP, TP53 apoptosis effector
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
POSTN periostin, osteoblast specific factor
PTN pleiotrophin
PTPRF protein tyrosine phosphatase, receptor type, F
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
TMOD1 tropomodulin 1
TNNT1 troponin T type 1 (skeletal, slow)
TRIM2 tripartite motif containing 2
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACACA acetyl-CoA carboxylase alpha
ACSL5 acyl-CoA synthetase long-chain family member 5
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AK1 adenylate kinase 1
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ARFIP2 ADP-ribosylation factor interacting protein 2
AXIN1 axin 1
BMI1 BMI1 proto-oncogene, polycomb ring finger
CD151 CD151 molecule (Raph blood group)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CTSG cathepsin G
CTSH cathepsin H
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CYTL1 cytokine-like 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EFHD2 EF-hand domain family, member D2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FKBP10 FK506 binding protein 10, 65 kDa
FPGS folylpolyglutamate synthase
GANAB glucosidase, alpha; neutral AB
GOLGA8H golgin A8 family, member H
HOMER1 homer scaffolding protein 1
HOPX HOP homeobox
ICMT isoprenylcysteine carboxyl methyltransferase
KAZN kazrin, periplakin interacting protein
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KIAA0100 KIAA0100
KIAA0485 uncharacterized LOC57235
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MARCKS myristoylated alanine-rich protein kinase C substrate
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLEC malectin
NFIB nuclear factor I/B
NPY neuropeptide Y
PDS5A PDS5 cohesin associated factor A
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PROM1 prominin 1
PTDSS1 phosphatidylserine synthase 1
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RERE arginine-glutamic acid dipeptide (RE) repeats
RPL36 ribosomal protein L36
RPS26 ribosomal protein S26
RRBP1 ribosome binding protein 1
S100P S100 calcium binding protein P
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPEN spen family transcriptional repressor
TALDO1 transaldolase 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGOLN2 trans-golgi network protein 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TSPAN8 tetraspanin 8
TXLNA taxilin alpha
UBR4 ubiquitin protein ligase E3 component n-recognin 4
WIPF2 WAS/WASL interacting protein family, member 2
ZMYM2 zinc finger, MYM-type 2