BRD-K28296557_Akt inhibitor IV_SW480_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

103 genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_SW480_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BEX1 brain expressed, X-linked 1
BID BH3 interacting domain death agonist
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
BSG basigin (Ok blood group)
BZW2 basic leucine zipper and W2 domains 2
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CES1 carboxylesterase 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL11A1 collagen, type XI, alpha 1
CSTA cystatin A (stefin A)
CYBB cytochrome b-245, beta polypeptide
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTT DNA nucleotidylexotransferase
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EGR2 early growth response 2
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GBP1 guanylate binding protein 1, interferon-inducible
H1FX H1 histone family, member X
HAPLN1 hyaluronan and proteoglycan link protein 1
HBB hemoglobin, beta
HBD hemoglobin, delta
HIST1H2BG histone cluster 1, H2bg
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
JUN jun proto-oncogene
JUNB jun B proto-oncogene
LCN2 lipocalin 2
LUM lumican
LYZ lysozyme
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MMP9 matrix metallopeptidase 9
MNDA myeloid cell nuclear differentiation antigen
MUC5B mucin 5B, oligomeric mucus/gel-forming
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX2-2 NK2 homeobox 2
OLFM4 olfactomedin 4
PLBD1 phospholipase B domain containing 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTN pleiotrophin
RGS5 regulator of G-protein signaling 5
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCPEP1 serine carboxypeptidase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGN serglycin
SRSF6 serine/arginine-rich splicing factor 6
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
ANKRD28 ankyrin repeat domain 28
AQP3 aquaporin 3 (Gill blood group)
BSPRY B-box and SPRY domain containing
C8ORF4 chromosome 8 open reading frame 4
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CANX calnexin
CCL20 chemokine (C-C motif) ligand 20
CEP170 centrosomal protein 170kDa
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DDHD2 DDHD domain containing 2
GOLPH3L golgi phosphoprotein 3-like
HEATR1 HEAT repeat containing 1
IFI44L interferon-induced protein 44-like
IL6ST interleukin 6 signal transducer
KAZN kazrin, periplakin interacting protein
KIAA0100 KIAA0100
KIAA0125 KIAA0125
KIAA0368 KIAA0368
LGALS1 lectin, galactoside-binding, soluble, 1
LPP LIM domain containing preferred translocation partner in lipoma
NBPF10 neuroblastoma breakpoint family, member 10
NCK1 NCK adaptor protein 1
NFIB nuclear factor I/B
NOTCH2 notch 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
PDS5A PDS5 cohesin associated factor A
PEG10 paternally expressed 10
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PPAT phosphoribosyl pyrophosphate amidotransferase
PRPF4 pre-mRNA processing factor 4
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
SEPT11 septin 11
SPATS2L spermatogenesis associated, serine-rich 2-like
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIAM1 T-cell lymphoma invasion and metastasis 1
TNC tenascin C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGCG UDP-glucose ceramide glucosyltransferase
ZBTB18 zinc finger and BTB domain containing 18