BRD-K28296557_Akt inhibitor IV_SKMEL28_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

145 genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_SKMEL28_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADIRF adipogenesis regulatory factor
AKR1C3 aldo-keto reductase family 1, member C3
ANPEP alanyl (membrane) aminopeptidase
ATF3 activating transcription factor 3
BCAM basal cell adhesion molecule (Lutheran blood group)
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CLCA1 chloride channel accessory 1
CLDN3 claudin 3
CLEC2B C-type lectin domain family 2, member B
CLIC2 chloride intracellular channel 2
CLU clusterin
COL15A1 collagen, type XV, alpha 1
COMP cartilage oligomeric matrix protein
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CSTA cystatin A (stefin A)
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DENND2D DENN/MADD domain containing 2D
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DLK1 delta-like 1 homolog (Drosophila)
EDNRA endothelin receptor type A
EGFL6 EGF-like-domain, multiple 6
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EPAS1 endothelial PAS domain protein 1
EXPH5 exophilin 5
F13A1 coagulation factor XIII, A1 polypeptide
FAS Fas cell surface death receptor
FXYD6 FXYD domain containing ion transport regulator 6
GAGE3 G antigen 3
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GRB7 growth factor receptor-bound protein 7
GREM1 gremlin 1, DAN family BMP antagonist
HBB hemoglobin, beta
HILPDA hypoxia inducible lipid droplet-associated
HSPA1A heat shock 70kDa protein 1A
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP5 insulin-like growth factor binding protein 5
IL17RB interleukin 17 receptor B
IL18 interleukin 18
ITM2A integral membrane protein 2A
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT8 keratin 8, type II
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOB monoamine oxidase B
MDK midkine (neurite growth-promoting factor 2)
MN1 meningioma (disrupted in balanced translocation) 1
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NID2 nidogen 2 (osteonidogen)
NT5E 5'-nucleotidase, ecto (CD73)
OSR2 odd-skipped related transciption factor 2
PAPD7 PAP associated domain containing 7
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRL platelet-derived growth factor receptor-like
PROM1 prominin 1
PRSS21 protease, serine, 21 (testisin)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RGCC regulator of cell cycle
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC38A1 solute carrier family 38, member 1
SPARCL1 SPARC-like 1 (hevin)
SPINT1 serine peptidase inhibitor, Kunitz type 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SSPN sarcospan
ST18 suppression of tumorigenicity 18, zinc finger
STC1 stanniocalcin 1
TMEM176B transmembrane protein 176B
TMSB15A thymosin beta 15a
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
VTCN1 V-set domain containing T cell activation inhibitor 1
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
ZNF131 zinc finger protein 131

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACSL1 acyl-CoA synthetase long-chain family member 1
ADCY1 adenylate cyclase 1 (brain)
ADD3 adducin 3 (gamma)
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BICD2 bicaudal D homolog 2 (Drosophila)
BST2 bone marrow stromal cell antigen 2
CDC123 cell division cycle 123
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CHPT1 choline phosphotransferase 1
CORO1C coronin, actin binding protein, 1C
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CXCL14 chemokine (C-X-C motif) ligand 14
EDNRB endothelin receptor type B
FKBP11 FK506 binding protein 11, 19 kDa
FOLR1 folate receptor 1 (adult)
GNAS GNAS complex locus
GPM6B glycoprotein M6B
GRSF1 G-rich RNA sequence binding factor 1
HSPA14 heat shock 70kDa protein 14
HTRA1 HtrA serine peptidase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IGF1R insulin-like growth factor 1 receptor
IGHM immunoglobulin heavy constant mu
LEF1 lymphoid enhancer-binding factor 1
LRRC16A leucine rich repeat containing 16A
MCAM melanoma cell adhesion molecule
MCUR1 mitochondrial calcium uniporter regulator 1
MGP matrix Gla protein
MKNK2 MAP kinase interacting serine/threonine kinase 2
MYH10 myosin, heavy chain 10, non-muscle
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPY1R neuropeptide Y receptor Y1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PITRM1 pitrilysin metallopeptidase 1
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRPF4 pre-mRNA processing factor 4
PXMP2 peroxisomal membrane protein 2, 22kDa
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RHOQ ras homolog family member Q
RPS11 ribosomal protein S11
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae)
SRP72 signal recognition particle 72kDa
STAT1 signal transducer and activator of transcription 1, 91kDa
STOM stomatin
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM47 transmembrane protein 47
TNC tenascin C
UGCG UDP-glucose ceramide glucosyltransferase
WASF3 WAS protein family, member 3
WDR37 WD repeat domain 37
YME1L1 YME1-like 1 ATPase
ZBTB18 zinc finger and BTB domain containing 18