BRD-K28296557_Akt inhibitor IV_SKLU1_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

149 genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_SKLU1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG6 adhesion G protein-coupled receptor G6
AIM2 absent in melanoma 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AQP1 aquaporin 1 (Colton blood group)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX4 brain expressed, X-linked 4
CADM1 cell adhesion molecule 1
CCNG2 cyclin G2
CD27 CD27 molecule
CHIC2 cysteine-rich hydrophobic domain 2
CLEC2B C-type lectin domain family 2, member B
CRABP1 cellular retinoic acid binding protein 1
CREB3L2 cAMP responsive element binding protein 3-like 2
CST1 cystatin SN
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DHRS7 dehydrogenase/reductase (SDR family) member 7
DIO1 deiodinase, iodothyronine, type I
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPYSL3 dihydropyrimidinase-like 3
DUSP6 dual specificity phosphatase 6
EGFR epidermal growth factor receptor
ETV1 ets variant 1
F11R F11 receptor
FAM129A family with sequence similarity 129, member A
FRY furry homolog (Drosophila)
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GPATCH8 G patch domain containing 8
GRB7 growth factor receptor-bound protein 7
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DOB major histocompatibility complex, class II, DO beta
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
INHBE inhibin, beta E
INSM1 insulinoma-associated 1
KLHL24 kelch-like family member 24
KRT15 keratin 15, type I
KRT23 keratin 23, type I
KRT7 keratin 7, type II
KRT8 keratin 8, type II
LITAF lipopolysaccharide-induced TNF factor
MBNL2 muscleblind-like splicing regulator 2
MMP7 matrix metallopeptidase 7
NAV2 neuron navigator 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
PEG3 paternally expressed 3
POU2AF1 POU class 2 associating factor 1
PROM1 prominin 1
PTN pleiotrophin
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RIOK3 RIO kinase 3
RNF167 ring finger protein 167
RTN2 reticulon 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SFRP1 secreted frizzled-related protein 1
SIK1 salt-inducible kinase 1
SOX9 SRY (sex determining region Y)-box 9
STX1A syntaxin 1A (brain)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM4SF1 transmembrane 4 L six family member 1
TM4SF4 transmembrane 4 L six family member 4
TMEM176B transmembrane protein 176B
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIM29 tripartite motif containing 29
TRPS1 trichorhinophalangeal syndrome I
TSC22D3 TSC22 domain family, member 3
TXNDC9 thioredoxin domain containing 9
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
USP10 ubiquitin specific peptidase 10
XPO7 exportin 7

decreased expression

Symbol Name
ACAT1 acetyl-CoA acetyltransferase 1
AKAP12 A kinase (PRKA) anchor protein 12
APOLD1 apolipoprotein L domain containing 1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
CA12 carbonic anhydrase XII
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNE2 cyclin E2
CD320 CD320 molecule
CDC25A cell division cycle 25A
CHMP4A charged multivesicular body protein 4A
CHPT1 choline phosphotransferase 1
CKB creatine kinase, brain
CLU clusterin
COG2 component of oligomeric golgi complex 2
CYBRD1 cytochrome b reductase 1
CYCS cytochrome c, somatic
CYTL1 cytokine-like 1
ECI2 enoyl-CoA delta isomerase 2
EPHB2 EPH receptor B2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FCGBP Fc fragment of IgG binding protein
FPGS folylpolyglutamate synthase
FUCA1 fucosidase, alpha-L- 1, tissue
GAS2L1 growth arrest-specific 2 like 1
GLIPR1 GLI pathogenesis-related 1
GPI glucose-6-phosphate isomerase
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HOXB7 homeobox B7
IL7R interleukin 7 receptor
IPO13 importin 13
IQGAP2 IQ motif containing GTPase activating protein 2
KIAA1033 KIAA1033
LAMC1 laminin, gamma 1 (formerly LAMB2)
LUC7L3 LUC7-like 3 (S. cerevisiae)
MSLN mesothelin
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPTX2 neuronal pentraxin II
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F6 nuclear receptor subfamily 2, group F, member 6
PI3 peptidase inhibitor 3, skin-derived
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PON2 paraoxonase 2
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PSENEN presenilin enhancer gamma secretase subunit
QDPR quinoid dihydropteridine reductase
RAB11A RAB11A, member RAS oncogene family
RFC2 replication factor C (activator 1) 2, 40kDa
RPL39L ribosomal protein L39-like
SCAF11 SR-related CTD-associated factor 11
SCAND1 SCAN domain containing 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SORBS1 sorbin and SH3 domain containing 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM251 transmembrane protein 251
TPD52L1 tumor protein D52-like 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TTC3 tetratricopeptide repeat domain 3
UGCG UDP-glucose ceramide glucosyltransferase
WFDC2 WAP four-disulfide core domain 2
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta