BRD-K28296557_Akt inhibitor IV_RMUGS_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

119 genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_RMUGS_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BST2 bone marrow stromal cell antigen 2
CALB1 calbindin 1, 28kDa
CCL21 chemokine (C-C motif) ligand 21
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFH complement factor H
CGRRF1 cell growth regulator with ring finger domain 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLEC2D C-type lectin domain family 2, member D
CLU clusterin
CTH cystathionine gamma-lyase
CTSW cathepsin W
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
E2F2 E2F transcription factor 2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP7 fatty acid binding protein 7, brain
FLG filaggrin
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GRAMD3 GRAM domain containing 3
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
IFITM1 interferon induced transmembrane protein 1
IFRD1 interferon-related developmental regulator 1
INHBE inhibin, beta E
LITAF lipopolysaccharide-induced TNF factor
LTBP3 latent transforming growth factor beta binding protein 3
MELK maternal embryonic leucine zipper kinase
MICALL1 MICAL-like 1
MT1G metallothionein 1G
MT1HL1 metallothionein 1H-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
N4BP2L2 NEDD4 binding protein 2-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLGN4X neuroligin 4, X-linked
OSER1 oxidative stress responsive serine-rich 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PROM1 prominin 1
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTMA prothymosin, alpha
QKI QKI, KH domain containing, RNA binding
RABGAP1L RAB GTPase activating protein 1-like
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNF114 ring finger protein 114
RORA RAR-related orphan receptor A
RSL24D1 ribosomal L24 domain containing 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A2 solute carrier family 38, member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SRSF7 serine/arginine-rich splicing factor 7
STAT1 signal transducer and activator of transcription 1, 91kDa
STC2 stanniocalcin 2
TLK1 tousled-like kinase 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
ZMYND8 zinc finger, MYND-type containing 8

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ACAA2 acetyl-CoA acyltransferase 2
AHNAK2 AHNAK nucleoprotein 2
ARL4C ADP-ribosylation factor-like 4C
BPHL biphenyl hydrolase-like (serine hydrolase)
C3ORF14 chromosome 3 open reading frame 14
CD36 CD36 molecule (thrombospondin receptor)
COLEC12 collectin sub-family member 12
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
DLK1 delta-like 1 homolog (Drosophila)
DPYD dihydropyrimidine dehydrogenase
EDN1 endothelin 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ERBB2 erb-b2 receptor tyrosine kinase 2
FABP4 fatty acid binding protein 4, adipocyte
GJA1 gap junction protein, alpha 1, 43kDa
GSTA4 glutathione S-transferase alpha 4
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGKC immunoglobulin kappa constant
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
INA internexin neuronal intermediate filament protein, alpha
INHBB inhibin, beta B
LAMP3 lysosomal-associated membrane protein 3
LMO3 LIM domain only 3 (rhombotin-like 2)
LPXN leupaxin
MEIS2 Meis homeobox 2
MFAP2 microfibrillar-associated protein 2
NELL2 NEL-like 2 (chicken)
NINL ninein-like
NTS neurotensin
PDLIM3 PDZ and LIM domain 3
POSTN periostin, osteoblast specific factor
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RIN2 Ras and Rab interactor 2
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SOX9 SRY (sex determining region Y)-box 9
SUGCT succinyl-CoA:glutarate-CoA transferase
TRIL TLR4 interactor with leucine-rich repeats
TUBB2A tubulin, beta 2A class IIa
VCAN versican
ZDHHC11 zinc finger, DHHC-type containing 11