BRD-K28296557_Akt inhibitor IV_RMGI_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

163 genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_RMGI_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AIM2 absent in melanoma 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BHLHE41 basic helix-loop-helix family, member e41
BMI1 BMI1 proto-oncogene, polycomb ring finger
BTG1 B-cell translocation gene 1, anti-proliferative
C8ORF4 chromosome 8 open reading frame 4
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCNG2 cyclin G2
CCNL1 cyclin L1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2AIP CDKN2A interacting protein
CHI3L2 chitinase 3-like 2
CHSY1 chondroitin sulfate synthase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL3A1 collagen, type III, alpha 1
CSRP1 cysteine and glycine-rich protein 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DST dystonin
DUSP1 dual specificity phosphatase 1
EFNA1 ephrin-A1
EGR1 early growth response 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXC1 forkhead box C1
FOXO3 forkhead box O3
FXYD2 FXYD domain containing ion transport regulator 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GMDS GDP-mannose 4,6-dehydratase
GOLGA8A golgin A8 family, member A
GPC3 glypican 3
GSE1 Gse1 coiled-coil protein
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
ICAM3 intercellular adhesion molecule 3
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM5B lysine (K)-specific demethylase 5B
KLF10 Kruppel-like factor 10
KLF5 Kruppel-like factor 5 (intestinal)
KLHL21 kelch-like family member 21
KYNU kynureninase
LDLR low density lipoprotein receptor
LIMCH1 LIM and calponin homology domains 1
LRRC1 leucine rich repeat containing 1
LTBP3 latent transforming growth factor beta binding protein 3
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MATN2 matrilin 2
MBNL2 muscleblind-like splicing regulator 2
MGP matrix Gla protein
MSMO1 methylsterol monooxygenase 1
MSRB2 methionine sulfoxide reductase B2
MTUS1 microtubule associated tumor suppressor 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCDH9 protocadherin 9
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIGP phosphatidylinositol glycan anchor biosynthesis, class P
PLAC8 placenta-specific 8
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGDS prostaglandin D2 synthase 21kDa (brain)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RRAGD Ras-related GTP binding D
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SCRN1 secernin 1
SEPP1 selenoprotein P, plasma, 1
SETBP1 SET binding protein 1
SFTPA2 surfactant protein A2
SIK1 salt-inducible kinase 1
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SOX9 SRY (sex determining region Y)-box 9
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM176B transmembrane protein 176B
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TSC22D2 TSC22 domain family, member 2
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
TUFT1 tuftelin 1
UBAP1 ubiquitin associated protein 1
USP6NL USP6 N-terminal like
ZNF292 zinc finger protein 292

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ALCAM activated leukocyte cell adhesion molecule
APMAP adipocyte plasma membrane associated protein
APOB apolipoprotein B
ATF5 activating transcription factor 5
AUTS2 autism susceptibility candidate 2
C3ORF14 chromosome 3 open reading frame 14
CA12 carbonic anhydrase XII
CALU calumenin
CCL5 chemokine (C-C motif) ligand 5
CCND2 cyclin D2
CD36 CD36 molecule (thrombospondin receptor)
CD9 CD9 molecule
CERS6 ceramide synthase 6
CRABP2 cellular retinoic acid binding protein 2
CST7 cystatin F (leukocystatin)
CTSB cathepsin B
CUX2 cut-like homeobox 2
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
EIF5A eukaryotic translation initiation factor 5A
EMX2 empty spiracles homeobox 2
ESR1 estrogen receptor 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FKBP9 FK506 binding protein 9, 63 kDa
GREM1 gremlin 1, DAN family BMP antagonist
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ITGA6 integrin, alpha 6
LAMA3 laminin, alpha 3
LAMP5 lysosomal-associated membrane protein family, member 5
LRRN3 leucine rich repeat neuronal 3
LYZ lysozyme
MAT2A methionine adenosyltransferase II, alpha
MLPH melanophilin
MSLN mesothelin
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MYOF myoferlin
NELL2 NEL-like 2 (chicken)
PDE8B phosphodiesterase 8B
PMM2 phosphomannomutase 2
PSD3 pleckstrin and Sec7 domain containing 3
RBP4 retinol binding protein 4, plasma
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SORD sorbitol dehydrogenase
STAT4 signal transducer and activator of transcription 4
STK10 serine/threonine kinase 10
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFF1 trefoil factor 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM47 transmembrane protein 47
TNIP1 TNFAIP3 interacting protein 1
VCAN versican
ZNF423 zinc finger protein 423