BRD-K28296557_Akt inhibitor IV_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

227 genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRF5 adhesion G protein-coupled receptor F5
ADIRF adipogenesis regulatory factor
ALOX5AP arachidonate 5-lipoxygenase-activating protein
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AREG amphiregulin
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
AUTS2 autism susceptibility candidate 2
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BGN biglycan
BHLHE40 basic helix-loop-helix family, member e40
BMP2 bone morphogenetic protein 2
BTG3 BTG family, member 3
C10ORF10 chromosome 10 open reading frame 10
CCNL1 cyclin L1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES2 carboxylesterase 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHKB choline kinase beta
CLIC5 chloride intracellular channel 5
CPA3 carboxypeptidase A3 (mast cell)
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CTGF connective tissue growth factor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAP death-associated protein
DCN decorin
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
EFNA1 ephrin-A1
EGFL6 EGF-like-domain, multiple 6
EPAS1 endothelial PAS domain protein 1
FAM69A family with sequence similarity 69, member A
FBN2 fibrillin 2
FILIP1L filamin A interacting protein 1-like
FOLR1 folate receptor 1 (adult)
GAS6 growth arrest-specific 6
GJA1 gap junction protein, alpha 1, 43kDa
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GREM1 gremlin 1, DAN family BMP antagonist
GUSBP3 glucuronidase, beta pseudogene 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IL32 interleukin 32
INSIG1 insulin induced gene 1
JCHAIN joining chain of multimeric IgA and IgM
KIAA0226L KIAA0226-like
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KLHL9 kelch-like family member 9
LDOC1 leucine zipper, down-regulated in cancer 1
LMO3 LIM domain only 3 (rhombotin-like 2)
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MSLN mesothelin
MT1E metallothionein 1E
NAT8 N-acetyltransferase 8 (GCN5-related, putative)
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH1 notch 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NRG1 neuregulin 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4C phosphodiesterase 4C, cAMP-specific
PDPN podoplanin
PEG10 paternally expressed 10
PLXNB2 plexin B2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKCI protein kinase C, iota
PRTN3 proteinase 3
PTPRO protein tyrosine phosphatase, receptor type, O
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A8 S100 calcium binding protein A8
SDC4 syndecan 4
SELENBP1 selenium binding protein 1
SGCE sarcoglycan, epsilon
SHB Src homology 2 domain containing adaptor protein B
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC35E1 solute carrier family 35, member E1
SNAI2 snail family zinc finger 2
SOCS2 suppressor of cytokine signaling 2
SQSTM1 sequestosome 1
SRGN serglycin
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STC1 stanniocalcin 1
SYT1 synaptotagmin I
TCF4 transcription factor 4
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRIB3 tribbles pseudokinase 3
TUBB2B tubulin, beta 2B class IIb
TWIST1 twist family bHLH transcription factor 1
USP34 ubiquitin specific peptidase 34
VEGFA vascular endothelial growth factor A
WIPI1 WD repeat domain, phosphoinositide interacting 1
XIST X inactive specific transcript (non-protein coding)
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein
ZNF721 zinc finger protein 721
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ACACB acetyl-CoA carboxylase beta
ACSL1 acyl-CoA synthetase long-chain family member 1
ADRB2 adrenoceptor beta 2, surface
AKAP7 A kinase (PRKA) anchor protein 7
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALG6 ALG6, alpha-1,3-glucosyltransferase
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
AURKA aurora kinase A
BCLAF1 BCL2-associated transcription factor 1
BLMH bleomycin hydrolase
BMI1 BMI1 proto-oncogene, polycomb ring finger
CASP7 caspase 7, apoptosis-related cysteine peptidase
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNE2 cyclin E2
CCNF cyclin F
CDC123 cell division cycle 123
CDC25A cell division cycle 25A
CHSY1 chondroitin sulfate synthase 1
COIL coilin
CTR9 CTR9, Paf1/RNA polymerase II complex component
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEGS1 delta(4)-desaturase, sphingolipid 1
DLAT dihydrolipoamide S-acetyltransferase
ECI2 enoyl-CoA delta isomerase 2
EED embryonic ectoderm development
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENDOD1 endonuclease domain containing 1
EXOSC4 exosome component 4
FAR2 fatty acyl CoA reductase 2
FASTKD5 FAST kinase domains 5
FLRT2 fibronectin leucine rich transmembrane protein 2
FOXC1 forkhead box C1
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
G0S2 G0/G1 switch 2
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GLIPR1 GLI pathogenesis-related 1
HACD2 3-hydroxyacyl-CoA dehydratase 2
HAT1 histone acetyltransferase 1
HLTF helicase-like transcription factor
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
HOXB7 homeobox B7
HOXC10 homeobox C10
HOXC6 homeobox C6
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
JARID2 jumonji, AT rich interactive domain 2
KANK2 KN motif and ankyrin repeat domains 2
KDM5D lysine (K)-specific demethylase 5D
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
LBR lamin B receptor
LCMT2 leucine carboxyl methyltransferase 2
LIPA lipase A, lysosomal acid, cholesterol esterase
LIPT1 lipoyltransferase 1
LOXL1 lysyl oxidase-like 1
LTF lactotransferrin
MAT2A methionine adenosyltransferase II, alpha
MFAP3 microfibrillar-associated protein 3
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAV3 neuron navigator 3
NMI N-myc (and STAT) interactor
NOTCH2 notch 2
NPY neuropeptide Y
NR2F2 nuclear receptor subfamily 2, group F, member 2
PCTP phosphatidylcholine transfer protein
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PITRM1 pitrilysin metallopeptidase 1
PNMA1 paraneoplastic Ma antigen 1
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PTGES prostaglandin E synthase
PURA purine-rich element binding protein A
RAD23B RAD23 homolog B (S. cerevisiae)
RNMT RNA (guanine-7-) methyltransferase
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP1B ribosomal RNA processing 1B
S100A7 S100 calcium binding protein A7
SACS sacsin molecular chaperone
SEH1L SEH1-like (S. cerevisiae)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC25A46 solute carrier family 25, member 46
SOAT1 sterol O-acyltransferase 1
SORD sorbitol dehydrogenase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
STEAP1 six transmembrane epithelial antigen of the prostate 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFB2M transcription factor B2, mitochondrial
TMPO thymopoietin
TMX4 thioredoxin-related transmembrane protein 4
TNC tenascin C
TRAPPC4 trafficking protein particle complex 4
TSPAN8 tetraspanin 8
UBE4A ubiquitination factor E4A
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
VCAN versican
WDR37 WD repeat domain 37
ZBTB18 zinc finger and BTB domain containing 18