BRD-K28296557_Akt inhibitor IV_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

356 genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AARS alanyl-tRNA synthetase
ADGRG6 adhesion G protein-coupled receptor G6
ALAS1 5'-aminolevulinate synthase 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOLD1 apolipoprotein L domain containing 1
ARMCX1 armadillo repeat containing, X-linked 1
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP11B ATPase, class VI, type 11B
BEX4 brain expressed, X-linked 4
BMP2 bone morphogenetic protein 2
C10ORF10 chromosome 10 open reading frame 10
CARS cysteinyl-tRNA synthetase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CBS cystathionine-beta-synthase
CCNL1 cyclin L1
CD40 CD40 molecule, TNF receptor superfamily member 5
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK14 cyclin-dependent kinase 14
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFB complement factor B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CTGF connective tissue growth factor
CTNND1 catenin (cadherin-associated protein), delta 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
DBT dihydrolipoamide branched chain transacylase E2
DCHS1 dachsous cadherin-related 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EDN1 endothelin 1
EPAS1 endothelial PAS domain protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EXT1 exostosin glycosyltransferase 1
FABP4 fatty acid binding protein 4, adipocyte
FAM69A family with sequence similarity 69, member A
FGFR2 fibroblast growth factor receptor 2
FILIP1L filamin A interacting protein 1-like
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
FZD1 frizzled class receptor 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GJA1 gap junction protein, alpha 1, 43kDa
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GOLGA8H golgin A8 family, member H
GSDMB gasdermin B
GTPBP2 GTP binding protein 2
GUSBP11 glucuronidase, beta pseudogene 11
HBEGF heparin-binding EGF-like growth factor
HDAC9 histone deacetylase 9
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA13 heat shock protein 70kDa family, member 13
ICAM1 intercellular adhesion molecule 1
IDO1 indoleamine 2,3-dioxygenase 1
IER5 immediate early response 5
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFRD1 interferon-related developmental regulator 1
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IRF9 interferon regulatory factor 9
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDR kinase insert domain receptor
LAMP3 lysosomal-associated membrane protein 3
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS4 lectin, galactoside-binding, soluble, 4
LIMCH1 LIM and calponin homology domains 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MARS methionyl-tRNA synthetase
MAST4 microtubule associated serine/threonine kinase family member 4
MCL1 myeloid cell leukemia 1
MEST mesoderm specific transcript
MTMR11 myotubularin related protein 11
MZB1 marginal zone B and B1 cell-specific protein
NAV2 neuron navigator 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NELL2 NEL-like 2 (chicken)
NEU1 sialidase 1 (lysosomal sialidase)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
NVL nuclear VCP-like
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
ORC1 origin recognition complex, subunit 1
OSBPL10 oxysterol binding protein-like 10
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PAWR PRKC, apoptosis, WT1, regulator
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDE4C phosphodiesterase 4C, cAMP-specific
PDE4DIP phosphodiesterase 4D interacting protein
PDZK1IP1 PDZK1 interacting protein 1
PELI1 pellino E3 ubiquitin protein ligase 1
PHGDH phosphoglycerate dehydrogenase
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PON3 paraoxonase 3
POSTN periostin, osteoblast specific factor
POU2AF1 POU class 2 associating factor 1
PPOX protoporphyrinogen oxidase
PRUNE2 prune homolog 2 (Drosophila)
PTBP2 polypyrimidine tract binding protein 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RTN2 reticulon 2
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SGCE sarcoglycan, epsilon
SGK1 serum/glucocorticoid regulated kinase 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SIK1 salt-inducible kinase 1
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SOCS2 suppressor of cytokine signaling 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SQSTM1 sequestosome 1
SRGN serglycin
SSPN sarcospan
STON1 stonin 1
SULF1 sulfatase 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TCEAL2 transcription elongation factor A (SII)-like 2
TESK1 testis-specific kinase 1
THBS2 thrombospondin 2
TM4SF1 transmembrane 4 L six family member 1
TMEM176B transmembrane protein 176B
TPP1 tripeptidyl peptidase I
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB3 tribbles pseudokinase 3
TUFT1 tuftelin 1
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VNN1 vanin 1
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
YARS tyrosyl-tRNA synthetase
ZEB1 zinc finger E-box binding homeobox 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACTB actin, beta
AK4 adenylate kinase 4
AKAP7 A kinase (PRKA) anchor protein 7
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDOA aldolase A, fructose-bisphosphate
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASPH aspartate beta-hydroxylase
ATAD2 ATPase family, AAA domain containing 2
BAG2 BCL2-associated athanogene 2
BCLAF1 BCL2-associated transcription factor 1
BLMH bleomycin hydrolase
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C16ORF45 chromosome 16 open reading frame 45
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCND1 cyclin D1
CCNE2 cyclin E2
CD58 CD58 molecule
CD9 CD9 molecule
CD99 CD99 molecule
CDC123 cell division cycle 123
CDC42 cell division cycle 42
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CKB creatine kinase, brain
CLU clusterin
CPD carboxypeptidase D
CPVL carboxypeptidase, vitellogenic-like
CRIP1 cysteine-rich protein 1 (intestinal)
CRYZ crystallin, zeta (quinone reductase)
CST3 cystatin C
CYFIP1 cytoplasmic FMR1 interacting protein 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCPS decapping enzyme, scavenger
DEFB1 defensin, beta 1
DHCR7 7-dehydrocholesterol reductase
DHFR dihydrofolate reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EBP emopamil binding protein (sterol isomerase)
ECI2 enoyl-CoA delta isomerase 2
EFHD1 EF-hand domain family, member D1
EIF4E eukaryotic translation initiation factor 4E
EMP2 epithelial membrane protein 2
ENDOG endonuclease G
ERGIC2 ERGIC and golgi 2
FAM162A family with sequence similarity 162, member A
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
G0S2 G0/G1 switch 2
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLUD1 glutamate dehydrogenase 1
GLUD2 glutamate dehydrogenase 2
GLUL glutamate-ammonia ligase
GPI glucose-6-phosphate isomerase
GRSF1 G-rich RNA sequence binding factor 1
GSTM3 glutathione S-transferase mu 3 (brain)
HADH hydroxyacyl-CoA dehydrogenase
HOXA10 homeobox A10
HOXC6 homeobox C6
HSDL2 hydroxysteroid dehydrogenase like 2
ICMT isoprenylcysteine carboxyl methyltransferase
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP5 insulin-like growth factor binding protein 5
IL1B interleukin 1, beta
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KRT10 keratin 10, type I
LAMA3 laminin, alpha 3
LIPA lipase A, lysosomal acid, cholesterol esterase
LMNB1 lamin B1
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYPLA1 lysophospholipase I
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MBP myelin basic protein
MCAM melanoma cell adhesion molecule
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MRPS30 mitochondrial ribosomal protein S30
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPC2 Niemann-Pick disease, type C2
NPY neuropeptide Y
NUSAP1 nucleolar and spindle associated protein 1
OAT ornithine aminotransferase
OXCT1 3-oxoacid CoA transferase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCCB propionyl CoA carboxylase, beta polypeptide
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PGAM1 phosphoglycerate mutase 1 (brain)
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PKM pyruvate kinase, muscle
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PPIF peptidylprolyl isomerase F
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRDX3 peroxiredoxin 3
PTGES prostaglandin E synthase
PTMA prothymosin, alpha
PURA purine-rich element binding protein A
RAD51C RAD51 paralog C
RBBP4 retinoblastoma binding protein 4
RPA3 replication protein A3, 14kDa
RPS5 ribosomal protein S5
S100A10 S100 calcium binding protein A10
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SELL selectin L
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SET SET nuclear proto-oncogene
SKP1 S-phase kinase-associated protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SORD sorbitol dehydrogenase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPAG4 sperm associated antigen 4
SRP72 signal recognition particle 72kDa
SRSF1 serine/arginine-rich splicing factor 1
TACC3 transforming, acidic coiled-coil containing protein 3
TBL1X transducin (beta)-like 1X-linked
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFDP1 transcription factor Dp-1
TMPO thymopoietin
TMX4 thioredoxin-related transmembrane protein 4
TNC tenascin C
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSPAN6 tetraspanin 6
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
UBL3 ubiquitin-like 3
VRK1 vaccinia related kinase 1
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
ZBTB18 zinc finger and BTB domain containing 18