BRD-K28296557_Akt inhibitor IV_NCIH596_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

187 genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_NCIH596_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACPP acid phosphatase, prostate
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AGR2 anterior gradient 2
APOD apolipoprotein D
ARHGAP29 Rho GTPase activating protein 29
ARL4A ADP-ribosylation factor-like 4A
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BIRC2 baculoviral IAP repeat containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKS2 CDC28 protein kinase regulatory subunit 2
CLDN10 claudin 10
CPE carboxypeptidase E
CSTA cystatin A (stefin A)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EDN3 endothelin 3
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM129A family with sequence similarity 129, member A
FGF13 fibroblast growth factor 13
FGL2 fibrinogen-like 2
FMO1 flavin containing monooxygenase 1
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GPC3 glypican 3
GPNMB glycoprotein (transmembrane) nmb
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD1 interferon-related developmental regulator 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KRT8 keratin 8, type II
LARP6 La ribonucleoprotein domain family, member 6
LDLR low density lipoprotein receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LMO4 LIM domain only 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MATN2 matrilin 2
MPO myeloperoxidase
MSMO1 methylsterol monooxygenase 1
MT1M metallothionein 1M
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFIL3 nuclear factor, interleukin 3 regulated
NGDN neuroguidin, EIF4E binding protein
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OSR2 odd-skipped related transciption factor 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK5 proprotein convertase subtilisin/kexin type 5
PDZK1IP1 PDZK1 interacting protein 1
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTN pleiotrophin
RGCC regulator of cell cycle
RORA RAR-related orphan receptor A
RRAGD Ras-related GTP binding D
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SEPP1 selenoprotein P, plasma, 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A1 solute carrier family 38, member 1
SOX9 SRY (sex determining region Y)-box 9
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPRY2 sprouty homolog 2 (Drosophila)
SRRM2 serine/arginine repetitive matrix 2
STAR steroidogenic acute regulatory protein
STC1 stanniocalcin 1
SYT1 synaptotagmin I
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TARS threonyl-tRNA synthetase
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
WLS wntless Wnt ligand secretion mediator
XBP1 X-box binding protein 1
YAP1 Yes-associated protein 1

decreased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AK1 adenylate kinase 1
AKAP7 A kinase (PRKA) anchor protein 7
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
BGN biglycan
C2CD5 C2 calcium-dependent domain containing 5
C3 complement component 3
CALD1 caldesmon 1
CBR3 carbonyl reductase 3
CCNE2 cyclin E2
CD200 CD200 molecule
CD96 CD96 molecule
CDC14B cell division cycle 14B
CKLF chemokine-like factor
COG2 component of oligomeric golgi complex 2
CREB1 cAMP responsive element binding protein 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM69A family with sequence similarity 69, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FSTL1 follistatin-like 1
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GNAS GNAS complex locus
GPC1 glypican 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KANK1 KN motif and ankyrin repeat domains 1
KIAA0125 KIAA0125
LAMC1 laminin, gamma 1 (formerly LAMB2)
LIMCH1 LIM and calponin homology domains 1
LYPLA1 lysophospholipase I
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MXRA7 matrix-remodelling associated 7
MYH10 myosin, heavy chain 10, non-muscle
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
OLFM1 olfactomedin 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLK1 polo-like kinase 1
PROM1 prominin 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RGS1 regulator of G-protein signaling 1
S100A8 S100 calcium binding protein A8
SDC1 syndecan 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLPI secretory leukocyte peptidase inhibitor
SORBS1 sorbin and SH3 domain containing 1
SRSF2 serine/arginine-rich splicing factor 2
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SULF1 sulfatase 1
TNS3 tensin 3
TSPAN13 tetraspanin 13
TUBB6 tubulin, beta 6 class V
TUBG1 tubulin, gamma 1
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)