BRD-K28296557_Akt inhibitor IV_NCIH2073_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

191 genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_NCIH2073_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACBD3 acyl-CoA binding domain containing 3
ACP5 acid phosphatase 5, tartrate resistant
ACTA1 actin, alpha 1, skeletal muscle
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADCK3 aarF domain containing kinase 3
AGTR1 angiotensin II receptor, type 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMOTL2 angiomotin like 2
AOX1 aldehyde oxidase 1
AQP9 aquaporin 9
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AXL AXL receptor tyrosine kinase
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CCNG2 cyclin G2
CEMIP cell migration inducing protein, hyaluronan binding
CHIC2 cysteine-rich hydrophobic domain 2
CHRDL1 chordin-like 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN7 claudin 7
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COMP cartilage oligomeric matrix protein
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CTH cystathionine gamma-lyase
CXCL5 chemokine (C-X-C motif) ligand 5
DCN decorin
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EXPH5 exophilin 5
F2RL1 coagulation factor II (thrombin) receptor-like 1
FKBP14 FK506 binding protein 14, 22 kDa
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GPX3 glutathione peroxidase 3
GSTT1 glutathione S-transferase theta 1
H1F0 H1 histone family, member 0
HIST3H2A histone cluster 3, H2a
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI27 interferon, alpha-inducible protein 27
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL6 interleukin 6
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LGALS4 lectin, galactoside-binding, soluble, 4
LOX lysyl oxidase
LRRC15 leucine rich repeat containing 15
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
MXI1 MAX interactor 1, dimerization protein
MYBPC1 myosin binding protein C, slow type
MYH2 myosin, heavy chain 2, skeletal muscle, adult
MYL1 myosin, light chain 1, alkali; skeletal, fast
MYL2 myosin, light chain 2, regulatory, cardiac, slow
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFIL3 nuclear factor, interleukin 3 regulated
NID2 nidogen 2 (osteonidogen)
NR1D2 nuclear receptor subfamily 1, group D, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCSK5 proprotein convertase subtilisin/kexin type 5
PDE4DIP phosphodiesterase 4D interacting protein
PDZRN3 PDZ domain containing ring finger 3
PHGDH phosphoglycerate dehydrogenase
PLAC8 placenta-specific 8
PLAGL1 pleiomorphic adenoma gene-like 1
PLAU plasminogen activator, urokinase
PROM1 prominin 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RB1CC1 RB1-inducible coiled-coil 1
RBP4 retinol binding protein 4, plasma
RHOQ ras homolog family member Q
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC25A46 solute carrier family 25, member 46
SLC38A2 solute carrier family 38, member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SLN sarcolipin
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
STC2 stanniocalcin 2
TBC1D15 TBC1 domain family, member 15
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNNT1 troponin T type 1 (skeletal, slow)
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TRIB3 tribbles pseudokinase 3
TST thiosulfate sulfurtransferase (rhodanese)
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UGCG UDP-glucose ceramide glucosyltransferase
UGP2 UDP-glucose pyrophosphorylase 2
WDTC1 WD and tetratricopeptide repeats 1
XYLT1 xylosyltransferase I

decreased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AQP3 aquaporin 3 (Gill blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
AUTS2 autism susceptibility candidate 2
CA12 carbonic anhydrase XII
CALML3 calmodulin-like 3
CAST calpastatin
CCDC86 coiled-coil domain containing 86
CCL5 chemokine (C-C motif) ligand 5
CCND2 cyclin D2
CD24 CD24 molecule
CD52 CD52 molecule
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CROT carnitine O-octanoyltransferase
CST7 cystatin F (leukocystatin)
CXADR coxsackie virus and adenovirus receptor
CXCL9 chemokine (C-X-C motif) ligand 9
DLD dihydrolipoamide dehydrogenase
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FCGBP Fc fragment of IgG binding protein
FGFR3 fibroblast growth factor receptor 3
FHOD3 formin homology 2 domain containing 3
FTH1 ferritin, heavy polypeptide 1
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GNAS GNAS complex locus
GRWD1 glutamate-rich WD repeat containing 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
KRT15 keratin 15, type I
KRT6A keratin 6A, type II
LEF1 lymphoid enhancer-binding factor 1
LRP4 low density lipoprotein receptor-related protein 4
LTBP1 latent transforming growth factor beta binding protein 1
LUM lumican
LYPD1 LY6/PLAUR domain containing 1
MEIS2 Meis homeobox 2
MYOF myoferlin
NR2F1 nuclear receptor subfamily 2, group F, member 1
NRCAM neuronal cell adhesion molecule
PEG10 paternally expressed 10
PON2 paraoxonase 2
PTCH1 patched 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RABGAP1L RAB GTPase activating protein 1-like
RBP1 retinol binding protein 1, cellular
REEP1 receptor accessory protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RNH1 ribonuclease/angiogenin inhibitor 1
RRM2 ribonucleotide reductase M2
SRGN serglycin
SRSF2 serine/arginine-rich splicing factor 2
SRSF3 serine/arginine-rich splicing factor 3
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM14A transmembrane protein 14A
TMEM2 transmembrane protein 2
TNC tenascin C
TP63 tumor protein p63
TSPAN12 tetraspanin 12
TUBB2A tubulin, beta 2A class IIa
VCAN versican
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta