BRD-K28296557_Akt inhibitor IV_MDST8_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

172 genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_MDST8_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRD10 ankyrin repeat domain 10
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
BCL6 B-cell CLL/lymphoma 6
BTG3 BTG family, member 3
C10ORF10 chromosome 10 open reading frame 10
C21ORF91 chromosome 21 open reading frame 91
CA2 carbonic anhydrase II
CCNG2 cyclin G2
CD24 CD24 molecule
CDC42 cell division cycle 42
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFLAR CASP8 and FADD-like apoptosis regulator
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP10 dual specificity phosphatase 10
ECM1 extracellular matrix protein 1
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EPAS1 endothelial PAS domain protein 1
FAM129A family with sequence similarity 129, member A
FST follistatin
GADD45A growth arrest and DNA-damage-inducible, alpha
GLA galactosidase, alpha
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IDO1 indoleamine 2,3-dioxygenase 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IRS2 insulin receptor substrate 2
ITGA6 integrin, alpha 6
JUN jun proto-oncogene
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KLHDC10 kelch domain containing 10
KLHL24 kelch-like family member 24
KRT14 keratin 14, type I
MDFIC MyoD family inhibitor domain containing
MFSD10 major facilitator superfamily domain containing 10
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP9 matrix metallopeptidase 9
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEB nebulin
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
NR4A3 nuclear receptor subfamily 4, group A, member 3
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RCAN1 regulator of calcineurin 1
RIPK2 receptor-interacting serine-threonine kinase 2
RLF rearranged L-myc fusion
SCGB1D2 secretoglobin, family 1D, member 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC38A1 solute carrier family 38, member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMAD5 SMAD family member 5
SPAG9 sperm associated antigen 9
SPEN spen family transcriptional repressor
SPP1 secreted phosphoprotein 1
SPRED2 sprouty-related, EVH1 domain containing 2
TFF3 trefoil factor 3 (intestinal)
TNS3 tensin 3
TP53BP2 tumor protein p53 binding protein 2
UBQLN2 ubiquilin 2
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADAM28 ADAM metallopeptidase domain 28
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
BST2 bone marrow stromal cell antigen 2
C7 complement component 7
CALD1 caldesmon 1
CCL2 chemokine (C-C motif) ligand 2
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CLU clusterin
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A2 collagen, type IV, alpha 2
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELOVL6 ELOVL fatty acid elongase 6
FBN1 fibrillin 1
FHL1 four and a half LIM domains 1
FUCA1 fucosidase, alpha-L- 1, tissue
GATA3 GATA binding protein 3
GLDC glycine dehydrogenase (decarboxylating)
GPX3 glutathione peroxidase 3
HES1 hes family bHLH transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
ISYNA1 inositol-3-phosphate synthase 1
KANK2 KN motif and ankyrin repeat domains 2
KAZN kazrin, periplakin interacting protein
KRT19 keratin 19, type I
LAMB1 laminin, beta 1
MARCKSL1 MARCKS-like 1
MGP matrix Gla protein
MSMB microseminoprotein, beta-
MYCBP MYC binding protein
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRCAM neuronal cell adhesion molecule
OBSL1 obscurin-like 1
PIR pirin (iron-binding nuclear protein)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNMAL1 paraneoplastic Ma antigen family-like 1
POSTN periostin, osteoblast specific factor
PRAME preferentially expressed antigen in melanoma
PRDX2 peroxiredoxin 2
PTRF polymerase I and transcript release factor
RBM3 RNA binding motif (RNP1, RRM) protein 3
RGS5 regulator of G-protein signaling 5
RRM2 ribonucleotide reductase M2
SEPT6 septin 6
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SORD sorbitol dehydrogenase
SOX2 SRY (sex determining region Y)-box 2
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TBL1X transducin (beta)-like 1X-linked
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM2 transmembrane protein 2
TNC tenascin C
TRIM14 tripartite motif containing 14
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UNC119B unc-119 homolog B (C. elegans)
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
VCAN versican
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta