BRD-K28296557_Akt inhibitor IV_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

139 genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKAP8L A kinase (PRKA) anchor protein 8-like
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BHLHE40 basic helix-loop-helix family, member e40
BMP2 bone morphogenetic protein 2
BRD4 bromodomain containing 4
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
CADM1 cell adhesion molecule 1
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EFNA1 ephrin-A1
EGR1 early growth response 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GPM6B glycoprotein M6B
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IDO1 indoleamine 2,3-dioxygenase 1
IER2 immediate early response 2
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
IGL immunoglobulin lambda locus
IRF1 interferon regulatory factor 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KLK5 kallikrein-related peptidase 5
KRT23 keratin 23, type I
LCN2 lipocalin 2
LITAF lipopolysaccharide-induced TNF factor
MBNL2 muscleblind-like splicing regulator 2
MGLL monoglyceride lipase
MT1F metallothionein 1F
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PLAU plasminogen activator, urokinase
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RAB20 RAB20, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RHOB ras homolog family member B
RND3 Rho family GTPase 3
RNF24 ring finger protein 24
RSRC2 arginine/serine-rich coiled-coil 2
S100A14 S100 calcium binding protein A14
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SFRP1 secreted frizzled-related protein 1
SIK1 salt-inducible kinase 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SMAD3 SMAD family member 3
SNAI2 snail family zinc finger 2
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TBX3 T-box 3
TGIF1 TGFB-induced factor homeobox 1
TLK2 tousled-like kinase 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACTA2 actin, alpha 2, smooth muscle, aorta
ADD3 adducin 3 (gamma)
ALCAM activated leukocyte cell adhesion molecule
ATF5 activating transcription factor 5
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
ATP9A ATPase, class II, type 9A
B3GNT1
BCHE butyrylcholinesterase
CCNE2 cyclin E2
CD14 CD14 molecule
CD52 CD52 molecule
CDC25A cell division cycle 25A
CROT carnitine O-octanoyltransferase
CX3CR1 chemokine (C-X3-C motif) receptor 1
DCLK1 doublecortin-like kinase 1
ECI2 enoyl-CoA delta isomerase 2
GLUD1 glutamate dehydrogenase 1
GNAS GNAS complex locus
IQGAP2 IQ motif containing GTPase activating protein 2
KIF14 kinesin family member 14
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAT2A methionine adenosyltransferase II, alpha
MET MET proto-oncogene, receptor tyrosine kinase
MYH10 myosin, heavy chain 10, non-muscle
NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa
NMU neuromedin U
OXTR oxytocin receptor
PRDX1 peroxiredoxin 1
PRDX3 peroxiredoxin 3
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKCA protein kinase C, alpha
PRPF4 pre-mRNA processing factor 4
RAD23B RAD23 homolog B (S. cerevisiae)
RAD51C RAD51 paralog C
RCN2 reticulocalbin 2, EF-hand calcium binding domain
SESN1 sestrin 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SYPL1 synaptophysin-like 1
TBC1D4 TBC1 domain family, member 4
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN3 tetraspanin 3
TSPYL4 TSPY-like 4
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
WRB tryptophan rich basic protein
WSB2 WD repeat and SOCS box containing 2
ZC3HAV1 zinc finger CCCH-type, antiviral 1