BRD-K28296557_Akt inhibitor IV_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

316 genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACKR3 atypical chemokine receptor 3
ADGRG6 adhesion G protein-coupled receptor G6
APOLD1 apolipoprotein L domain containing 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CAPN2 calpain 2, (m/II) large subunit
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCDC92 coiled-coil domain containing 92
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CREB3L2 cAMP responsive element binding protein 3-like 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EFNA1 ephrin-A1
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FNDC3B fibronectin type III domain containing 3B
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO3 forkhead box O3
FXYD5 FXYD domain containing ion transport regulator 5
FYN FYN proto-oncogene, Src family tyrosine kinase
FZD5 frizzled class receptor 5
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GRB10 growth factor receptor-bound protein 10
H3F3B H3 histone, family 3B (H3.3B)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HYOU1 hypoxia up-regulated 1
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IL32 interleukin 32
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KRT23 keratin 23, type I
KRT81 keratin 81, type II
LAMB3 laminin, beta 3
LARP6 La ribonucleoprotein domain family, member 6
LITAF lipopolysaccharide-induced TNF factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARS methionyl-tRNA synthetase
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MMP7 matrix metallopeptidase 7
MTSS1 metastasis suppressor 1
MYO1D myosin ID
NBPF10 neuroblastoma breakpoint family, member 10
NFE2L3 nuclear factor, erythroid 2-like 3
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
PAWR PRKC, apoptosis, WT1, regulator
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PLVAP plasmalemma vesicle associated protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PROM1 prominin 1
PSAT1 phosphoserine aminotransferase 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPRE protein tyrosine phosphatase, receptor type, E
RBMS1 RNA binding motif, single stranded interacting protein 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERTAD2 SERTA domain containing 2
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SIK1 salt-inducible kinase 1
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SQSTM1 sequestosome 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TES testin LIM domain protein
TGFA transforming growth factor, alpha
TGIF1 TGFB-induced factor homeobox 1
TGM2 transglutaminase 2
TIMP1 TIMP metallopeptidase inhibitor 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TRIM16 tripartite motif containing 16
TRIM2 tripartite motif containing 2
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
YARS tyrosyl-tRNA synthetase
YPEL5 yippee-like 5 (Drosophila)
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZYX zyxin

decreased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ADD3 adducin 3 (gamma)
ADI1 acireductone dioxygenase 1
ANGPT1 angiopoietin 1
ARMT1 acidic residue methyltransferase 1
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
AURKB aurora kinase B
B3GNT1
BAG3 BCL2-associated athanogene 3
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNE2 cyclin E2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC7 cell division cycle 7
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPM centromere protein M
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
COL1A2 collagen, type I, alpha 2
COL6A3 collagen, type VI, alpha 3
COMMD8 COMM domain containing 8
COX7B cytochrome c oxidase subunit VIIb
CRYZ crystallin, zeta (quinone reductase)
CSE1L CSE1 chromosome segregation 1-like (yeast)
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCK deoxycytidine kinase
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
E2F8 E2F transcription factor 8
EFCAB11 EF-hand calcium binding domain 11
EMP2 epithelial membrane protein 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
GHR growth hormone receptor
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GPER1 G protein-coupled estrogen receptor 1
GSTM3 glutathione S-transferase mu 3 (brain)
GTF2H5 general transcription factor IIH, polypeptide 5
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HADH hydroxyacyl-CoA dehydrogenase
HIST1H4C histone cluster 1, H4c
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXC10 homeobox C10
HOXC6 homeobox C6
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGFBP5 insulin-like growth factor binding protein 5
ISOC1 isochorismatase domain containing 1
KIAA0101 KIAA0101
KIAA0391 KIAA0391
KIAA1467 KIAA1467
KIF11 kinesin family member 11
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
LDHB lactate dehydrogenase B
LIG1 ligase I, DNA, ATP-dependent
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARC1 mitochondrial amidoxime reducing component 1
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MRPL16 mitochondrial ribosomal protein L16
MRPL20 mitochondrial ribosomal protein L20
MRPS2 mitochondrial ribosomal protein S2
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MUC1 mucin 1, cell surface associated
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPY neuropeptide Y
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
ORC6 origin recognition complex, subunit 6
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PEX11A peroxisomal biogenesis factor 11 alpha
PLIN1 perilipin 1
PLK1 polo-like kinase 1
PMPCA peptidase (mitochondrial processing) alpha
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSRC1 proline/serine-rich coiled-coil 1
PTTG1 pituitary tumor-transforming 1
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RAD54B RAD54 homolog B (S. cerevisiae)
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS4 regulator of G-protein signaling 4
RNASEH2A ribonuclease H2, subunit A
RPA3 replication protein A3, 14kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SELT selenoprotein T
SHCBP1 SHC SH2-domain binding protein 1
SKP1 S-phase kinase-associated protein 1
SLIRP SRA stem-loop interacting RNA binding protein
SMC2 structural maintenance of chromosomes 2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SPDEF SAM pointed domain containing ETS transcription factor
SPDL1 spindle apparatus coiled-coil protein 1
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TFDP1 transcription factor Dp-1
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TK1 thymidine kinase 1, soluble
TMEM14A transmembrane protein 14A
TMEM97 transmembrane protein 97
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TTK TTK protein kinase
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein