BRD-K28296557_Akt inhibitor IV_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

198 genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AKAP13 A kinase (PRKA) anchor protein 13
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
ATF6 activating transcription factor 6
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BAG3 BCL2-associated athanogene 3
BCL6 B-cell CLL/lymphoma 6
BTG1 B-cell translocation gene 1, anti-proliferative
CARS cysteinyl-tRNA synthetase
CCNG2 cyclin G2
CCPG1 cell cycle progression 1
CDK19 cyclin-dependent kinase 19
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
CREB3L2 cAMP responsive element binding protein 3-like 2
CSTA cystatin A (stefin A)
CTH cystathionine gamma-lyase
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND5A DENN/MADD domain containing 5A
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP1 dual specificity phosphatase 1
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF1 eukaryotic translation initiation factor 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5 eukaryotic translation initiation factor 5
ELL2 elongation factor, RNA polymerase II, 2
EPAS1 endothelial PAS domain protein 1
EZR ezrin
FADS1 fatty acid desaturase 1
FAM129A family with sequence similarity 129, member A
FBN2 fibrillin 2
FHL2 four and a half LIM domains 2
FKBP14 FK506 binding protein 14, 22 kDa
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GOLGB1 golgin B1
GRB10 growth factor receptor-bound protein 10
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HYOU1 hypoxia up-regulated 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGHD immunoglobulin heavy constant delta
IL6ST interleukin 6 signal transducer
INHBE inhibin, beta E
IRF9 interferon regulatory factor 9
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLHL24 kelch-like family member 24
KYNU kynureninase
LARP6 La ribonucleoprotein domain family, member 6
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARS methionyl-tRNA synthetase
MBNL2 muscleblind-like splicing regulator 2
MFAP5 microfibrillar associated protein 5
MID1IP1 MID1 interacting protein 1
MKNK2 MAP kinase interacting serine/threonine kinase 2
MME membrane metallo-endopeptidase
MOCOS molybdenum cofactor sulfurase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MXI1 MAX interactor 1, dimerization protein
MYO1D myosin ID
NEB nebulin
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
OSER1 oxidative stress responsive serine-rich 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDLIM5 PDZ and LIM domain 5
PER1 period circadian clock 1
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIOK3 RIO kinase 3
RIPK2 receptor-interacting serine-threonine kinase 2
RLF rearranged L-myc fusion
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SEC24A SEC24 family member A
SEC24D SEC24 family member D
SEC62 SEC62 homolog (S. cerevisiae)
SEC63 SEC63 homolog (S. cerevisiae)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TBL1X transducin (beta)-like 1X-linked
TFE3 transcription factor binding to IGHM enhancer 3
TIMP1 TIMP metallopeptidase inhibitor 1
TLK2 tousled-like kinase 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
UGDH UDP-glucose 6-dehydrogenase
USP3 ubiquitin specific peptidase 3
VEGFA vascular endothelial growth factor A
WAC WW domain containing adaptor with coiled-coil
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase
ZNF165 zinc finger protein 165

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
B3GNT1
CDC25A cell division cycle 25A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CXADR coxsackie virus and adenovirus receptor
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DEFA5 defensin, alpha 5, Paneth cell-specific
FABP1 fatty acid binding protein 1, liver
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FERMT1 fermitin family member 1
GATA2 GATA binding protein 2
GEMIN6 gem (nuclear organelle) associated protein 6
GPM6A glycoprotein M6A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
ITGB1BP1 integrin beta 1 binding protein 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
PLAC8 placenta-specific 8
PLN phospholamban
PODXL podocalyxin-like
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPARG peroxisome proliferator-activated receptor gamma
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RGS2 regulator of G-protein signaling 2
RPP40 ribonuclease P/MRP 40kDa subunit
SMYD2 SET and MYND domain containing 2
SPINK1 serine peptidase inhibitor, Kazal type 1
SRSF7 serine/arginine-rich splicing factor 7
TARBP1 TAR (HIV-1) RNA binding protein 1
TFPI2 tissue factor pathway inhibitor 2
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TMEM14A transmembrane protein 14A
TRIM14 tripartite motif containing 14
TRMT61B tRNA methyltransferase 61B
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UNG uracil-DNA glycosylase
VDAC3 voltage-dependent anion channel 3
WWP1 WW domain containing E3 ubiquitin protein ligase 1