BRD-K28296557_Akt inhibitor IV_HT29_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

430 genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_HT29_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABHD4 abhydrolase domain containing 4
ADGRG1 adhesion G protein-coupled receptor G1
AIM2 absent in melanoma 2
ANKRD10 ankyrin repeat domain 10
ARF4 ADP-ribosylation factor 4
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATF6 activating transcription factor 6
BAG3 BCL2-associated athanogene 3
BLVRB biliverdin reductase B
BTG1 B-cell translocation gene 1, anti-proliferative
CARS cysteinyl-tRNA synthetase
CCPG1 cell cycle progression 1
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CKAP4 cytoskeleton-associated protein 4
CLCN3 chloride channel, voltage-sensitive 3
CLDN3 claudin 3
CLIC4 chloride intracellular channel 4
COPA coatomer protein complex, subunit alpha
COPB1 coatomer protein complex, subunit beta 1
COPB2 coatomer protein complex, subunit beta 2 (beta prime)
CREB3L2 cAMP responsive element binding protein 3-like 2
CRELD2 cysteine-rich with EGF-like domains 2
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTH cystathionine gamma-lyase
CTSL cathepsin L
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL5 chemokine (C-X-C motif) ligand 5
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP5 dual specificity phosphatase 5
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EGFL6 EGF-like-domain, multiple 6
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
FAM114A1 family with sequence similarity 114, member A1
FAM129A family with sequence similarity 129, member A
FAM134A family with sequence similarity 134, member A
FAM134B family with sequence similarity 134, member B
FBN2 fibrillin 2
FEM1C fem-1 homolog c (C. elegans)
FICD FIC domain containing
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
FOXO3 forkhead box O3
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GLRX glutaredoxin (thioltransferase)
GMPPA GDP-mannose pyrophosphorylase A
GNB5 guanine nucleotide binding protein (G protein), beta 5
GOLGA4 golgin A4
GOLGB1 golgin B1
GOLPH3L golgi phosphoprotein 3-like
GORASP2 golgi reassembly stacking protein 2, 55kDa
GRB10 growth factor receptor-bound protein 10
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HDLBP high density lipoprotein binding protein
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
HYOU1 hypoxia up-regulated 1
IDS iduronate 2-sulfatase
IFI6 interferon, alpha-inducible protein 6
IFRD1 interferon-related developmental regulator 1
IGL immunoglobulin lambda locus
IL6 interleukin 6
INSIG1 insulin induced gene 1
IQCG IQ motif containing G
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD6 jumonji domain containing 6
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
KYNU kynureninase
LARP6 La ribonucleoprotein domain family, member 6
LDLR low density lipoprotein receptor
LIN37 lin-37 DREAM MuvB core complex component
LMO4 LIM domain only 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MANF mesencephalic astrocyte-derived neurotrophic factor
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MARS methionyl-tRNA synthetase
MCL1 myeloid cell leukemia 1
METTL21B methyltransferase like 21B
MIA3 melanoma inhibitory activity family, member 3
MIR22HG MIR22 host gene
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLPH melanophilin
MXI1 MAX interactor 1, dimerization protein
NAMPT nicotinamide phosphoribosyltransferase
NDEL1 nudE neurodevelopment protein 1-like 1
NEU1 sialidase 1 (lysosomal sialidase)
NFE2L1 nuclear factor, erythroid 2-like 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NRBF2 nuclear receptor binding factor 2
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
OSER1 oxidative stress responsive serine-rich 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
P4HB prolyl 4-hydroxylase, beta polypeptide
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PER1 period circadian clock 1
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMP22 peripheral myelin protein 22
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRRC1 proline-rich coiled-coil 1
PRSS8 protease, serine, 8
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
RAB9A RAB9A, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RAP1GAP RAP1 GTPase activating protein
RB1CC1 RB1-inducible coiled-coil 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOQ ras homolog family member Q
RIOK3 RIO kinase 3
RRAGC Ras-related GTP binding C
RRAGD Ras-related GTP binding D
SARS seryl-tRNA synthetase
SDF2L1 stromal cell-derived factor 2-like 1
SEC23B Sec23 homolog B (S. cerevisiae)
SEC24A SEC24 family member A
SEC24D SEC24 family member D
SEC31A SEC31 homolog A (S. cerevisiae)
SEC62 SEC62 homolog (S. cerevisiae)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERP1 stress-associated endoplasmic reticulum protein 1
SERTAD2 SERTA domain containing 2
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SIK3 SIK family kinase 3
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC35B1 solute carrier family 35, member B1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SOD2 superoxide dismutase 2, mitochondrial
SPTSSA serine palmitoyltransferase, small subunit A
SQSTM1 sequestosome 1
SRP19 signal recognition particle 19kDa
STC2 stanniocalcin 2
SUCO SUN domain containing ossification factor
TACC2 transforming, acidic coiled-coil containing protein 2
TARS threonyl-tRNA synthetase
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBL2 transducin (beta)-like 2
TFE3 transcription factor binding to IGHM enhancer 3
TLK2 tousled-like kinase 2
TMEM214 transmembrane protein 214
TMEM39A transmembrane protein 39A
TMEM41B transmembrane protein 41B
TMEM45A transmembrane protein 45A
TPP1 tripeptidyl peptidase I
TRAK2 trafficking protein, kinesin binding 2
TRDV3 T cell receptor delta variable 3
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TSPAN31 tetraspanin 31
TSPYL2 TSPY-like 2
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WBP2 WW domain binding protein 2
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AHCY adenosylhomocysteinase
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
AREG amphiregulin
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
BID BH3 interacting domain death agonist
BMP4 bone morphogenetic protein 4
BZW2 basic leucine zipper and W2 domains 2
C1QBP complement component 1, q subcomponent binding protein
C7 complement component 7
CA9 carbonic anhydrase IX
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CASP6 caspase 6, apoptosis-related cysteine peptidase
CBFB core-binding factor, beta subunit
CCNA2 cyclin A2
CCNE2 cyclin E2
CCNF cyclin F
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDK1 cyclin-dependent kinase 1
CFI complement factor I
CKLF chemokine-like factor
COCH cochlin
CRYZ crystallin, zeta (quinone reductase)
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTPS1 CTP synthase 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYB5A cytochrome b5 type A (microsomal)
CYBA cytochrome b-245, alpha polypeptide
DCK deoxycytidine kinase
DCTPP1 dCTP pyrophosphatase 1
DEK DEK proto-oncogene
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF4E eukaryotic translation initiation factor 4E
EMP2 epithelial membrane protein 2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ESR1 estrogen receptor 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FANCL Fanconi anemia, complementation group L
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
FERMT1 fermitin family member 1
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FPGS folylpolyglutamate synthase
GATA2 GATA binding protein 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
GSTM3 glutathione S-transferase mu 3 (brain)
GTF2A2 general transcription factor IIA, 2, 12kDa
GTF2H5 general transcription factor IIH, polypeptide 5
H2AFX H2A histone family, member X
HACD3 3-hydroxyacyl-CoA dehydratase 3
HADH hydroxyacyl-CoA dehydrogenase
HES1 hes family bHLH transcription factor 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HMGB1 high mobility group box 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMGN3 high mobility group nucleosomal binding domain 3
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HPRT1 hypoxanthine phosphoribosyltransferase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IGFBP7 insulin-like growth factor binding protein 7
ILF3 interleukin enhancer binding factor 3, 90kDa
ISYNA1 inositol-3-phosphate synthase 1
ITGB1BP1 integrin beta 1 binding protein 1
KANK1 KN motif and ankyrin repeat domains 1
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KLK10 kallikrein-related peptidase 10
KRT13 keratin 13, type I
KRT19 keratin 19, type I
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LOXL1 lysyl oxidase-like 1
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LUM lumican
LYPLA1 lysophospholipase I
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARCKSL1 MARCKS-like 1
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MGST2 microsomal glutathione S-transferase 2
MKI67 marker of proliferation Ki-67
MRPL20 mitochondrial ribosomal protein L20
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MXRA5 matrix-remodelling associated 5
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NAE1 NEDD8 activating enzyme E1 subunit 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPD3 non-SMC condensin II complex, subunit D3
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NMU neuromedin U
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP210 nucleoporin 210kDa
OIP5 Opa interacting protein 5
PARP1 poly (ADP-ribose) polymerase 1
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDGFD platelet derived growth factor D
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PLAT plasminogen activator, tissue
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPIF peptidylprolyl isomerase F
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PXMP2 peroxisomal membrane protein 2, 22kDa
RAD51 RAD51 recombinase
RANBP1 RAN binding protein 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBBP4 retinoblastoma binding protein 4
RBMX RNA binding motif protein, X-linked
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RELN reelin
RFC3 replication factor C (activator 1) 3, 38kDa
RGS2 regulator of G-protein signaling 2
RGS4 regulator of G-protein signaling 4
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPA3 replication protein A3, 14kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A4 S100 calcium binding protein A4
SEPT11 septin 11
SEPW1 selenoprotein W, 1
SIVA1 SIVA1, apoptosis-inducing factor
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMC2 structural maintenance of chromosomes 2
SMYD2 SET and MYND domain containing 2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SNRPE small nuclear ribonucleoprotein polypeptide E
SNRPF small nuclear ribonucleoprotein polypeptide F
SNRPG small nuclear ribonucleoprotein polypeptide G
SORD sorbitol dehydrogenase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPC25 SPC25, NDC80 kinetochore complex component
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRR3 small proline-rich protein 3
SRM spermidine synthase
SRSF1 serine/arginine-rich splicing factor 1
SRSF2 serine/arginine-rich splicing factor 2
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SUMO3 small ubiquitin-like modifier 3
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFDP1 transcription factor Dp-1
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TMEM109 transmembrane protein 109
TMEM14A transmembrane protein 14A
TMEM47 transmembrane protein 47
TMPO thymopoietin
TRAP1 TNF receptor-associated protein 1
TRIP13 thyroid hormone receptor interactor 13
TSPAN6 tetraspanin 6
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
UBE2N ubiquitin-conjugating enzyme E2N
UNG uracil-DNA glycosylase
VRK1 vaccinia related kinase 1
WDR61 WD repeat domain 61
XIST X inactive specific transcript (non-protein coding)
ZWINT ZW10 interacting kinetochore protein