BRD-K28296557_Akt inhibitor IV_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

69 genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG1 B-cell translocation gene 1, anti-proliferative
C3ORF14 chromosome 3 open reading frame 14
CADM1 cell adhesion molecule 1
CCL4 chemokine (C-C motif) ligand 4
CRABP2 cellular retinoic acid binding protein 2
DPYSL3 dihydropyrimidinase-like 3
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
FAM129A family with sequence similarity 129, member A
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GAB2 GRB2-associated binding protein 2
GADD45B growth arrest and DNA-damage-inducible, beta
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPNMB glycoprotein (transmembrane) nmb
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IL1B interleukin 1, beta
JUN jun proto-oncogene
KLF6 Kruppel-like factor 6
LRRC15 leucine rich repeat containing 15
MEG3 maternally expressed 3 (non-protein coding)
MMP2 matrix metallopeptidase 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
PRAME preferentially expressed antigen in melanoma
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PXDN peroxidasin
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
SGK1 serum/glucocorticoid regulated kinase 1
SNAI2 snail family zinc finger 2
SST somatostatin
STC1 stanniocalcin 1
TCF4 transcription factor 4
THBS2 thrombospondin 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TWIST1 twist family bHLH transcription factor 1
VTCN1 V-set domain containing T cell activation inhibitor 1
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AK1 adenylate kinase 1
AMD1 adenosylmethionine decarboxylase 1
AQP3 aquaporin 3 (Gill blood group)
ATF5 activating transcription factor 5
BASP1 brain abundant, membrane attached signal protein 1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CLU clusterin
CPVL carboxypeptidase, vitellogenic-like
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL12 chemokine (C-X-C motif) ligand 12
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
PALLD palladin, cytoskeletal associated protein
PON2 paraoxonase 2
PRDX2 peroxiredoxin 2
QDPR quinoid dihydropteridine reductase
RAD23B RAD23 homolog B (S. cerevisiae)
SFRP1 secreted frizzled-related protein 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
STOM stomatin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)