BRD-K28296557_Akt inhibitor IV_HCT116_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

153 genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_HCT116_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AKAP12 A kinase (PRKA) anchor protein 12
ANXA1 annexin A1
APOD apolipoprotein D
AREG amphiregulin
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAMBI BMP and activin membrane-bound inhibitor
CALD1 caldesmon 1
CARS cysteinyl-tRNA synthetase
CCND2 cyclin D2
CCNG2 cyclin G2
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CDK14 cyclin-dependent kinase 14
CHIC2 cysteine-rich hydrophobic domain 2
CLIC4 chloride intracellular channel 4
COL4A5 collagen, type IV, alpha 5
COL5A2 collagen, type V, alpha 2
CREB3L2 cAMP responsive element binding protein 3-like 2
CTGF connective tissue growth factor
CTSB cathepsin B
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSG2 desmoglein 2
EGR1 early growth response 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
F2R coagulation factor II (thrombin) receptor
FAM129A family with sequence similarity 129, member A
FBN2 fibrillin 2
FERMT2 fermitin family member 2
FN1 fibronectin 1
FRMD4B FERM domain containing 4B
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GBP1 guanylate binding protein 1, interferon-inducible
GLRX glutaredoxin (thioltransferase)
GOLT1B golgi transport 1B
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
HLA-DRA major histocompatibility complex, class II, DR alpha
IFI16 interferon, gamma-inducible protein 16
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
IL6ST interleukin 6 signal transducer
INHBA inhibin, beta A
KRT23 keratin 23, type I
LMO3 LIM domain only 3 (rhombotin-like 2)
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MME membrane metallo-endopeptidase
NFIL3 nuclear factor, interleukin 3 regulated
PDE8B phosphodiesterase 8B
PDGFC platelet derived growth factor C
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHGDH phosphoglycerate dehydrogenase
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PTN pleiotrophin
RB1 retinoblastoma 1
RB1CC1 RB1-inducible coiled-coil 1
RBP4 retinol binding protein 4, plasma
RCAN1 regulator of calcineurin 1
S100A1 S100 calcium binding protein A1
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP1 secreted frizzled-related protein 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STC2 stanniocalcin 2
SULF1 sulfatase 1
THBS1 thrombospondin 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRPS1 trichorhinophalangeal syndrome I
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZMAT3 zinc finger, matrin-type 3
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AKAP8 A kinase (PRKA) anchor protein 8
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ATMIN ATM interactor
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CD81 CD81 molecule
CDC25A cell division cycle 25A
CH25H cholesterol 25-hydroxylase
CHERP calcium homeostasis endoplasmic reticulum protein
CLDN10 claudin 10
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL6 chemokine (C-X-C motif) ligand 6
DBF4 DBF4 zinc finger
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
ECI2 enoyl-CoA delta isomerase 2
EDNRB endothelin receptor type B
ETFB electron-transfer-flavoprotein, beta polypeptide
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAIM Fas apoptotic inhibitory molecule
FAM57A family with sequence similarity 57, member A
FUS FUS RNA binding protein
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GAL galanin/GMAP prepropeptide
GCH1 GTP cyclohydrolase 1
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPA8 heat shock 70kDa protein 8
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KDM5D lysine (K)-specific demethylase 5D
KLF4 Kruppel-like factor 4 (gut)
LPCAT1 lysophosphatidylcholine acyltransferase 1
LTF lactotransferrin
MGLL monoglyceride lipase
MRPL12 mitochondrial ribosomal protein L12
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUP210 nucleoporin 210kDa
NUP62 nucleoporin 62kDa
OXA1L oxidase (cytochrome c) assembly 1-like
PNP purine nucleoside phosphorylase
PODXL podocalyxin-like
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRDX2 peroxiredoxin 2
PROM1 prominin 1
PRPF4 pre-mRNA processing factor 4
RBP1 retinol binding protein 1, cellular
RET ret proto-oncogene
RNF167 ring finger protein 167
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP1B ribosomal RNA processing 1B
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SRSF7 serine/arginine-rich splicing factor 7
SRSF8 serine/arginine-rich splicing factor 8
STEAP3 STEAP family member 3, metalloreductase
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM109 transmembrane protein 109
TMEM97 transmembrane protein 97
TPPP3 tubulin polymerization-promoting protein family member 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAT1 vesicle amine transport 1