BRD-K28296557_Akt inhibitor IV_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

97 genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ANKRD10 ankyrin repeat domain 10
ANXA3 annexin A3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHIC2 cysteine-rich hydrophobic domain 2
CNOT4 CCR4-NOT transcription complex, subunit 4
COBL cordon-bleu WH2 repeat protein
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
ECD ecdysoneless homolog (Drosophila)
EGR1 early growth response 1
ELL2 elongation factor, RNA polymerase II, 2
FHL2 four and a half LIM domains 2
FSD1 fibronectin type III and SPRY domain containing 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM1 intercellular adhesion molecule 1
IGHM immunoglobulin heavy constant mu
INSIG1 insulin induced gene 1
KRT18 keratin 18, type I
MAP2K5 mitogen-activated protein kinase kinase 5
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NFIL3 nuclear factor, interleukin 3 regulated
OSBPL10 oxysterol binding protein-like 10
PDLIM5 PDZ and LIM domain 5
RPS11 ribosomal protein S11
SERTAD2 SERTA domain containing 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOCS2 suppressor of cytokine signaling 2
TLK2 tousled-like kinase 2
TRIB3 tribbles pseudokinase 3
USP3 ubiquitin specific peptidase 3
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase
ZYX zyxin

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ANXA4 annexin A4
ATF5 activating transcription factor 5
C1ORF106 chromosome 1 open reading frame 106
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CD99 CD99 molecule
CDC25A cell division cycle 25A
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A2 collagen, type IV, alpha 2
CP ceruloplasmin (ferroxidase)
CST6 cystatin E/M
CTBP1 C-terminal binding protein 1
CXCL14 chemokine (C-X-C motif) ligand 14
GLO1 glyoxalase I
GPX3 glutathione peroxidase 3
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HOPX HOP homeobox
HRSP12 heat-responsive protein 12
LUC7L3 LUC7-like 3 (S. cerevisiae)
LYPD1 LY6/PLAUR domain containing 1
MARCKSL1 MARCKS-like 1
MCM4 minichromosome maintenance complex component 4
NRN1 neuritin 1
PDGFD platelet derived growth factor D
PDLIM3 PDZ and LIM domain 3
PI3 peptidase inhibitor 3, skin-derived
POSTN periostin, osteoblast specific factor
RALGDS ral guanine nucleotide dissociation stimulator
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGL1 ral guanine nucleotide dissociation stimulator-like 1
S100A8 S100 calcium binding protein A8
SFN stratifin
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLPI secretory leukocyte peptidase inhibitor
SOX4 SRY (sex determining region Y)-box 4
SRSF7 serine/arginine-rich splicing factor 7
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TFPI2 tissue factor pathway inhibitor 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)