BRD-K28296557_Akt inhibitor IV_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

143 genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX3 armadillo repeat containing, X-linked 3
ARMCX6 armadillo repeat containing, X-linked 6
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CTSL cathepsin L
DAP death-associated protein
DDIT3 DNA-damage-inducible transcript 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP6 dual specificity phosphatase 6
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
GARS glycyl-tRNA synthetase
GNAS GNAS complex locus
GRB10 growth factor receptor-bound protein 10
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
LIMCH1 LIM and calponin homology domains 1
LPL lipoprotein lipase
MAOA monoamine oxidase A
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
N4BP2L2 NEDD4 binding protein 2-like 2
NPC1 Niemann-Pick disease, type C1
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PPIB peptidylprolyl isomerase B (cyclophilin B)
PTX3 pentraxin 3, long
PYCR1 pyrroline-5-carboxylate reductase 1
RBKS ribokinase
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS10 regulator of G-protein signaling 10
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SFTPB surfactant protein B
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORBS2 sorbin and SH3 domain containing 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
STC2 stanniocalcin 2
TCEA2 transcription elongation factor A (SII), 2
TFE3 transcription factor binding to IGHM enhancer 3
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
XPOT exportin, tRNA

decreased expression

Symbol Name
AEBP1 AE binding protein 1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ARL4C ADP-ribosylation factor-like 4C
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASRGL1 asparaginase like 1
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
BZW2 basic leucine zipper and W2 domains 2
CA12 carbonic anhydrase XII
CALR calreticulin
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CENPM centromere protein M
CENPU centromere protein U
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DEFB1 defensin, beta 1
DHFR dihydrofolate reductase
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EXO1 exonuclease 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FJX1 four jointed box 1 (Drosophila)
GAS1 growth arrest-specific 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HELLS helicase, lymphoid-specific
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HP haptoglobin
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LYPD1 LY6/PLAUR domain containing 1
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NASP nuclear autoantigenic sperm protein (histone-binding)
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NSG1 neuron specific gene family member 1
NUP62 nucleoporin 62kDa
NUP85 nucleoporin 85kDa
NUSAP1 nucleolar and spindle associated protein 1
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLAGL1 pleiomorphic adenoma gene-like 1
PRC1 protein regulator of cytokinesis 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RBP1 retinol binding protein 1, cellular
RFC2 replication factor C (activator 1) 2, 40kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SHCBP1 SHC SH2-domain binding protein 1
SRSF2 serine/arginine-rich splicing factor 2
TFRC transferrin receptor
TIMELESS timeless circadian clock
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM97 transmembrane protein 97
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM4 tropomyosin 4
TRIB2 tribbles pseudokinase 2
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
VCAN versican
ZWINT ZW10 interacting kinetochore protein