BRD-K28296557_Akt inhibitor IV_HCC15_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

101 genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_HCC15_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARG2 arginase 2
ARHGAP29 Rho GTPase activating protein 29
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BLNK B-cell linker
CCNG2 cyclin G2
CD40 CD40 molecule, TNF receptor superfamily member 5
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
CHIC2 cysteine-rich hydrophobic domain 2
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP14 dual specificity phosphatase 14
EDNRA endothelin receptor type A
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EMX2 empty spiracles homeobox 2
FAM129A family with sequence similarity 129, member A
FAM69A family with sequence similarity 69, member A
FBXL12 F-box and leucine-rich repeat protein 12
FILIP1L filamin A interacting protein 1-like
GADD45A growth arrest and DNA-damage-inducible, alpha
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
HEATR1 HEAT repeat containing 1
HECA headcase homolog (Drosophila)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLV2-23 immunoglobulin lambda variable 2-23
KRT23 keratin 23, type I
LARP6 La ribonucleoprotein domain family, member 6
LGALS4 lectin, galactoside-binding, soluble, 4
LPAR6 lysophosphatidic acid receptor 6
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
NLRP2 NLR family, pyrin domain containing 2
NUPR1 nuclear protein, transcriptional regulator, 1
OSBPL10 oxysterol binding protein-like 10
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDZRN3 PDZ domain containing ring finger 3
POU2AF1 POU class 2 associating factor 1
PRR15L proline rich 15-like
PTPRO protein tyrosine phosphatase, receptor type, O
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC38A1 solute carrier family 38, member 1
SOX9 SRY (sex determining region Y)-box 9
SPINT1 serine peptidase inhibitor, Kunitz type 1
TMEM176B transmembrane protein 176B
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
VEGFA vascular endothelial growth factor A
VNN1 vanin 1
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1

decreased expression

Symbol Name
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CRIP1 cysteine-rich protein 1 (intestinal)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTL1 cytokine-like 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBXO11 F-box protein 11
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
KIF14 kinesin family member 14
LAPTM4B lysosomal protein transmembrane 4 beta
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCKSL1 MARCKS-like 1
MRPS16 mitochondrial ribosomal protein S16
NTS neurotensin
PLP1 proteolipid protein 1
RBP1 retinol binding protein 1, cellular
RPS5 ribosomal protein S5
S100A2 S100 calcium binding protein A2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SYBU syntabulin (syntaxin-interacting)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNC tenascin C
TSPAN7 tetraspanin 7