BRD-K28296557_Akt inhibitor IV_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

133 genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ALOX15B arachidonate 15-lipoxygenase, type B
ATF3 activating transcription factor 3
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BGN biglycan
BHLHE41 basic helix-loop-helix family, member e41
C10ORF10 chromosome 10 open reading frame 10
CADM1 cell adhesion molecule 1
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
FLT1 fms-related tyrosine kinase 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FXYD6 FXYD domain containing ion transport regulator 6
G0S2 G0/G1 switch 2
GNAS GNAS complex locus
GPM6B glycoprotein M6B
HAPLN1 hyaluronan and proteoglycan link protein 1
HIST1H1C histone cluster 1, H1c
HIST1H2AE histone cluster 1, H2ae
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HK2 hexokinase 2
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
JUN jun proto-oncogene
KLK10 kallikrein-related peptidase 10
KLK8 kallikrein-related peptidase 8
LAPTM5 lysosomal protein transmembrane 5
LOC100505650 uncharacterized LOC100505650
LYZ lysozyme
MSLN mesothelin
MUC16 mucin 16, cell surface associated
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
PLVAP plasmalemma vesicle associated protein
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PTPRO protein tyrosine phosphatase, receptor type, O
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
SCG2 secretogranin II
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SOCS2 suppressor of cytokine signaling 2
SOX17 SRY (sex determining region Y)-box 17
SOX4 SRY (sex determining region Y)-box 4
SPARCL1 SPARC-like 1 (hevin)
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TWIST1 twist family bHLH transcription factor 1
TYROBP TYRO protein tyrosine kinase binding protein
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA7 annexin A7
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASB13 ankyrin repeat and SOCS box containing 13
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BASP1 brain abundant, membrane attached signal protein 1
BIN1 bridging integrator 1
CCNG2 cyclin G2
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CST3 cystatin C
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYTH1 cytohesin 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPYSL2 dihydropyrimidinase-like 2
ECI2 enoyl-CoA delta isomerase 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPS15 epidermal growth factor receptor pathway substrate 15
F13A1 coagulation factor XIII, A1 polypeptide
FAM168B family with sequence similarity 168, member B
FBLN1 fibulin 1
FBN1 fibrillin 1
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GRB10 growth factor receptor-bound protein 10
HAT1 histone acetyltransferase 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGHM immunoglobulin heavy constant mu
IL6ST interleukin 6 signal transducer
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
MIR22HG MIR22 host gene
MKL2 MKL/myocardin-like 2
MTCL1 microtubule crosslinking factor 1
MYH10 myosin, heavy chain 10, non-muscle
MYLK myosin light chain kinase
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
PALLD palladin, cytoskeletal associated protein
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PFN2 profilin 2
PLA2G15 phospholipase A2, group XV
PRDX1 peroxiredoxin 1
PRSS23 protease, serine, 23
RBBP4 retinoblastoma binding protein 4
RFX5 regulatory factor X, 5 (influences HLA class II expression)
S100A7 S100 calcium binding protein A7
SCP2 sterol carrier protein 2
SEPP1 selenoprotein P, plasma, 1
SIAH2 siah E3 ubiquitin protein ligase 2
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SMAD7 SMAD family member 7
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TANK TRAF family member-associated NFKB activator
TATDN2 TatD DNase domain containing 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM14A transmembrane protein 14A
TMEM2 transmembrane protein 2
TOP2B topoisomerase (DNA) II beta 180kDa
TRAK1 trafficking protein, kinesin binding 1
TUBB2A tubulin, beta 2A class IIa
UBE3C ubiquitin protein ligase E3C
VPREB3 pre-B lymphocyte 3
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae)
ZBTB18 zinc finger and BTB domain containing 18
ZNF106 zinc finger protein 106