BRD-K28296557_Akt inhibitor IV_H1299_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

164 genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_H1299_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AEBP1 AE binding protein 1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BAG3 BCL2-associated athanogene 3
BGN biglycan
C1R complement component 1, r subcomponent
C5 complement component 5
CADM1 cell adhesion molecule 1
CALB1 calbindin 1, 28kDa
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCNL1 cyclin L1
CD69 CD69 molecule
CDC42 cell division cycle 42
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CH25H cholesterol 25-hydroxylase
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CISH cytokine inducible SH2-containing protein
COCH cochlin
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
FASTKD5 FAST kinase domains 5
FGG fibrinogen gamma chain
FLRT3 fibronectin leucine rich transmembrane protein 3
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO3 forkhead box O3
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GUSBP3 glucuronidase, beta pseudogene 3
HILPDA hypoxia inducible lipid droplet-associated
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HNRNPL heterogeneous nuclear ribonucleoprotein L
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IFRD1 interferon-related developmental regulator 1
INSIG1 insulin induced gene 1
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPT microtubule-associated protein tau
MCL1 myeloid cell leukemia 1
MEG3 maternally expressed 3 (non-protein coding)
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFIL3 nuclear factor, interleukin 3 regulated
NUTF2 nuclear transport factor 2
OPHN1 oligophrenin 1
PDE4C phosphodiesterase 4C, cAMP-specific
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTPRO protein tyrosine phosphatase, receptor type, O
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RELN reelin
REPIN1 replication initiator 1
RHOB ras homolog family member B
RHOBTB3 Rho-related BTB domain containing 3
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SCD5 stearoyl-CoA desaturase 5
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC35F2 solute carrier family 35, member F2
SRSF6 serine/arginine-rich splicing factor 6
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
TRIB3 tribbles pseudokinase 3
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZNF586 zinc finger protein 586
ZNF721 zinc finger protein 721

decreased expression

Symbol Name
ADAMDEC1 ADAM-like, decysin 1
ADIRF adipogenesis regulatory factor
ADRB2 adrenoceptor beta 2, surface
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA4 annexin A4
ATMIN ATM interactor
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
BASP1 brain abundant, membrane attached signal protein 1
CA2 carbonic anhydrase II
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CIRBP cold inducible RNA binding protein
CKB creatine kinase, brain
CLCA2 chloride channel accessory 2
CLEC3B C-type lectin domain family 3, member B
CXCL10 chemokine (C-X-C motif) ligand 10
CYBRD1 cytochrome b reductase 1
DAPK1 death-associated protein kinase 1
DCAF6 DDB1 and CUL4 associated factor 6
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DUOX2 dual oxidase 2
FCGBP Fc fragment of IgG binding protein
GCLM glutamate-cysteine ligase, modifier subunit
GPX2 glutathione peroxidase 2
GSTM3 glutathione S-transferase mu 3 (brain)
H2AFZ H2A histone family, member Z
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
KRT17 keratin 17, type I
KRT7 keratin 7, type II
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
NQO1 NAD(P)H dehydrogenase, quinone 1
PCNA proliferating cell nuclear antigen
PEA15 phosphoprotein enriched in astrocytes 15
PFN2 profilin 2
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKCH protein kinase C, eta
PSCA prostate stem cell antigen
RFTN1 raftlin, lipid raft linker 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCGB2A2 secretoglobin, family 2A, member 2
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SLC38A1 solute carrier family 38, member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SNN stannin
SORBS2 sorbin and SH3 domain containing 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SYNM synemin, intermediate filament protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
ZNF131 zinc finger protein 131