BRD-K28296557_Akt inhibitor IV_AGS_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

170 genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_AGS_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AARS alanyl-tRNA synthetase
ADGRF5 adhesion G protein-coupled receptor F5
AKAP9 A kinase (PRKA) anchor protein 9
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARG2 arginase 2
ARHGAP29 Rho GTPase activating protein 29
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL6 B-cell CLL/lymphoma 6
C10ORF10 chromosome 10 open reading frame 10
CBS cystathionine-beta-synthase
CCL4 chemokine (C-C motif) ligand 4
CD14 CD14 molecule
CD163 CD163 molecule
CD9 CD9 molecule
CD93 CD93 molecule
CDK19 cyclin-dependent kinase 19
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CLEC2B C-type lectin domain family 2, member B
COL4A1 collagen, type IV, alpha 1
COL9A3 collagen, type IX, alpha 3
CSTA cystatin A (stefin A)
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTH cystathionine gamma-lyase
CXCL10 chemokine (C-X-C motif) ligand 10
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DOCK4 dedicator of cytokinesis 4
DUSP1 dual specificity phosphatase 1
EFNA1 ephrin-A1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
FBP1 fructose-1,6-bisphosphatase 1
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FN1 fibronectin 1
FOXO3 forkhead box O3
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GADD45B growth arrest and DNA-damage-inducible, beta
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GNLY granulysin
GRB10 growth factor receptor-bound protein 10
H1F0 H1 histone family, member 0
HBB hemoglobin, beta
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IGFBP7 insulin-like growth factor binding protein 7
INHBE inhibin, beta E
IRF9 interferon regulatory factor 9
IRS2 insulin receptor substrate 2
JMJD1C jumonji domain containing 1C
KLHL24 kelch-like family member 24
KRT15 keratin 15, type I
KRT5 keratin 5, type II
KYNU kynureninase
LDLR low density lipoprotein receptor
LIMCH1 LIM and calponin homology domains 1
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MARS methionyl-tRNA synthetase
MCTP1 multiple C2 domains, transmembrane 1
MMP10 matrix metallopeptidase 10
MT1E metallothionein 1E
MTSS1 metastasis suppressor 1
MYO5C myosin VC
MYO6 myosin VI
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PECAM1 platelet/endothelial cell adhesion molecule 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRUNE2 prune homolog 2 (Drosophila)
PTN pleiotrophin
PTPRE protein tyrosine phosphatase, receptor type, E
RGS5 regulator of G-protein signaling 5
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SH3BP4 SH3-domain binding protein 4
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SIX2 SIX homeobox 2
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX11 SRY (sex determining region Y)-box 11
SPARCL1 SPARC-like 1 (hevin)
SPEN spen family transcriptional repressor
SRGN serglycin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMSB15A thymosin beta 15a
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIM2 tripartite motif containing 2
TYROBP TYRO protein tyrosine kinase binding protein
VEGFA vascular endothelial growth factor A
VWF von Willebrand factor
ZKSCAN1 zinc finger with KRAB and SCAN domains 1

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ANXA4 annexin A4
ANXA6 annexin A6
ASPA aspartoacylase
ATP5L ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G
CAPN3 calpain 3, (p94)
CD44 CD44 molecule (Indian blood group)
CDC25A cell division cycle 25A
CDKN3 cyclin-dependent kinase inhibitor 3
CHL1 cell adhesion molecule L1-like
CLIC4 chloride intracellular channel 4
CNIH1 cornichon family AMPA receptor auxiliary protein 1
CRELD2 cysteine-rich with EGF-like domains 2
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
DEPTOR DEP domain containing MTOR-interacting protein
EAF2 ELL associated factor 2
ELP5 elongator acetyltransferase complex subunit 5
EPHA3 EPH receptor A3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM46A family with sequence similarity 46, member A
FGFR3 fibroblast growth factor receptor 3
GGCT gamma-glutamylcyclotransferase
GREM1 gremlin 1, DAN family BMP antagonist
GRWD1 glutamate-rich WD repeat containing 1
HAVCR1 hepatitis A virus cellular receptor 1
HDDC2 HD domain containing 2
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LYPLA1 lysophospholipase I
MAP7 microtubule-associated protein 7
MARCKSL1 MARCKS-like 1
MAT2A methionine adenosyltransferase II, alpha
MFSD10 major facilitator superfamily domain containing 10
NME4 NME/NM23 nucleoside diphosphate kinase 4
NQO1 NAD(P)H dehydrogenase, quinone 1
PAM peptidylglycine alpha-amidating monooxygenase
PDCD2 programmed cell death 2
PLSCR3 phospholipid scramblase 3
PRSS23 protease, serine, 23
QPRT quinolinate phosphoribosyltransferase
RBPMS RNA binding protein with multiple splicing
RPL31 ribosomal protein L31
RPS17 ribosomal protein S17
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SRSF7 serine/arginine-rich splicing factor 7
TESC tescalcin
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIMP3 TIMP metallopeptidase inhibitor 3
TOX thymocyte selection-associated high mobility group box
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
U2SURP U2 snRNP-associated SURP domain containing
UXS1 UDP-glucuronate decarboxylase 1