BRD-K28296557_Akt inhibitor IV_A673_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

144 genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_A673_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BGN biglycan
BTG1 B-cell translocation gene 1, anti-proliferative
C3ORF14 chromosome 3 open reading frame 14
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHMP4A charged multivesicular body protein 4A
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN3 claudin 3
CPE carboxypeptidase E
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
EFNB2 ephrin-B2
EGR1 early growth response 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXO4 forkhead box O4
FXYD2 FXYD domain containing ion transport regulator 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSBP3 glucuronidase, beta pseudogene 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
KLHL24 kelch-like family member 24
KRT15 keratin 15, type I
MAN2B1 mannosidase, alpha, class 2B, member 1
METRN meteorin, glial cell differentiation regulator
MFSD10 major facilitator superfamily domain containing 10
MSMO1 methylsterol monooxygenase 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NSUN5P1 NOP2/Sun domain family, member 5 pseudogene 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK1 proprotein convertase subtilisin/kexin type 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G16 phospholipase A2, group XVI
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRUNE2 prune homolog 2 (Drosophila)
PTPRO protein tyrosine phosphatase, receptor type, O
PVRL3 poliovirus receptor-related 3
RGS16 regulator of G-protein signaling 16
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
S100A10 S100 calcium binding protein A10
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SQLE squalene epoxidase
STC2 stanniocalcin 2
SYNGR3 synaptogyrin 3
THBS2 thrombospondin 2
TM4SF1 transmembrane 4 L six family member 1
TMEM243 transmembrane protein 243, mitochondrial
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b

decreased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACSL5 acyl-CoA synthetase long-chain family member 5
ADD3 adducin 3 (gamma)
ASPH aspartate beta-hydroxylase
ATMIN ATM interactor
BTBD3 BTB (POZ) domain containing 3
C16ORF45 chromosome 16 open reading frame 45
CD93 CD93 molecule
CERS6 ceramide synthase 6
CLC Charcot-Leyden crystal galectin
COL4A1 collagen, type IV, alpha 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
DAPK1 death-associated protein kinase 1
EDNRA endothelin receptor type A
F13A1 coagulation factor XIII, A1 polypeptide
F3 coagulation factor III (thromboplastin, tissue factor)
FAM189A2 family with sequence similarity 189, member A2
FBLN1 fibulin 1
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCGBP Fc fragment of IgG binding protein
FLRT2 fibronectin leucine rich transmembrane protein 2
FSCN1 fascin actin-bundling protein 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GOLGA8B golgin A8 family, member B
GPRC5A G protein-coupled receptor, class C, group 5, member A
HACD3 3-hydroxyacyl-CoA dehydratase 3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA2 heat shock 70kDa protein 2
IFI44 interferon-induced protein 44
ITPKB inositol-trisphosphate 3-kinase B
KIAA0100 KIAA0100
KIAA0355 KIAA0355
MAPK6 mitogen-activated protein kinase 6
MFAP2 microfibrillar-associated protein 2
MT1M metallothionein 1M
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NDRG2 NDRG family member 2
NT5E 5'-nucleotidase, ecto (CD73)
NYNRIN NYN domain and retroviral integrase containing
PBX3 pre-B-cell leukemia homeobox 3
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PSCA prostate stem cell antigen
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RCN2 reticulocalbin 2, EF-hand calcium binding domain
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RRP1B ribosomal RNA processing 1B
RXRA retinoid X receptor, alpha
SELL selectin L
SEPW1 selenoprotein W, 1
SET SET nuclear proto-oncogene
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SORD sorbitol dehydrogenase
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
SYNM synemin, intermediate filament protein
TCF12 transcription factor 12
TM9SF3 transmembrane 9 superfamily member 3
TMEM2 transmembrane protein 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TTC3 tetratricopeptide repeat domain 3
UBE3C ubiquitin protein ligase E3C
WBP1L WW domain binding protein 1-like
ZCCHC14 zinc finger, CCHC domain containing 14
ZDHHC6 zinc finger, DHHC-type containing 6
ZNF106 zinc finger protein 106