BRD-K28296557_Akt inhibitor IV_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

117 genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG2 BTG family, member 2
CCL4 chemokine (C-C motif) ligand 4
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CRYAB crystallin, alpha B
CTTN cortactin
CXCL2 chemokine (C-X-C motif) ligand 2
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ELF5 E74-like factor 5 (ets domain transcription factor)
EPCAM epithelial cell adhesion molecule
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FZD7 frizzled class receptor 7
GADD45B growth arrest and DNA-damage-inducible, beta
GSN gelsolin
HBB hemoglobin, beta
HIST1H2BG histone cluster 1, H2bg
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER2 immediate early response 2
IER5 immediate early response 5
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
INA internexin neuronal intermediate filament protein, alpha
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCTD12 potassium channel tetramerization domain containing 12
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
L1CAM L1 cell adhesion molecule
LUM lumican
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MMP7 matrix metallopeptidase 7
MT1X metallothionein 1X
MUC5B mucin 5B, oligomeric mucus/gel-forming
NDRG1 N-myc downstream regulated 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OBSL1 obscurin-like 1
PLXNB2 plexin B2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RHOB ras homolog family member B
S100A10 S100 calcium binding protein A10
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SIK1 salt-inducible kinase 1
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SRRM2 serine/arginine repetitive matrix 2
TF transferrin
TOB2 transducer of ERBB2, 2
TPD52L1 tumor protein D52-like 1
VTCN1 V-set domain containing T cell activation inhibitor 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AKAP7 A kinase (PRKA) anchor protein 7
ANXA3 annexin A3
AQP4 aquaporin 4
AREG amphiregulin
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
CCDC47 coiled-coil domain containing 47
CD58 CD58 molecule
CDCA4 cell division cycle associated 4
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
COX11 COX11 cytochrome c oxidase copper chaperone
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSH cathepsin H
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL6 chemokine (C-X-C motif) ligand 6
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GNS glucosamine (N-acetyl)-6-sulfatase
GOLGA8B golgin A8 family, member B
HACD3 3-hydroxyacyl-CoA dehydratase 3
HSPA13 heat shock protein 70kDa family, member 13
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
LYPLA1 lysophospholipase I
MRPS28 mitochondrial ribosomal protein S28
NPY neuropeptide Y
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
RBM3 RNA binding motif (RNP1, RRM) protein 3
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100P S100 calcium binding protein P
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TBX3 T-box 3
TCF4 transcription factor 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM4SF1 transmembrane 4 L six family member 1
TSNAX translin-associated factor X
TSPAN6 tetraspanin 6
TYRP1 tyrosinase-related protein 1
VCAN versican