BRD-K28120860_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-K28120860_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX5 arachidonate 5-lipoxygenase
ANXA11 annexin A11
AREG amphiregulin
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CA2 carbonic anhydrase II
CBS cystathionine-beta-synthase
CD44 CD44 molecule (Indian blood group)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CTTN cortactin
CXADR coxsackie virus and adenovirus receptor
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP6 dual specificity phosphatase 6
FGF2 fibroblast growth factor 2 (basic)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
FSD1 fibronectin type III and SPRY domain containing 1
GDF15 growth differentiation factor 15
GJA1 gap junction protein, alpha 1, 43kDa
GPM6B glycoprotein M6B
HACD2 3-hydroxyacyl-CoA dehydratase 2
HBEGF heparin-binding EGF-like growth factor
HMOX1 heme oxygenase 1
IFRD1 interferon-related developmental regulator 1
IGL immunoglobulin lambda locus
IL7R interleukin 7 receptor
LOC100505650 uncharacterized LOC100505650
LTB lymphotoxin beta (TNF superfamily, member 3)
LUM lumican
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARS methionyl-tRNA synthetase
MKNK2 MAP kinase interacting serine/threonine kinase 2
MTF2 metal response element binding transcription factor 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
OLFM4 olfactomedin 4
PDE4B phosphodiesterase 4B, cAMP-specific
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLIN2 perilipin 2
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PSAT1 phosphoserine aminotransferase 1
QPCT glutaminyl-peptide cyclotransferase
RCAN1 regulator of calcineurin 1
RND3 Rho family GTPase 3
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SGK1 serum/glucocorticoid regulated kinase 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A1 solute carrier family 38, member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
STC2 stanniocalcin 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRIB3 tribbles pseudokinase 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase

decreased expression

Symbol Name
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES1 carboxylesterase 1
COL4A5 collagen, type IV, alpha 5
CST3 cystatin C
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DAPK1 death-associated protein kinase 1
EFNB2 ephrin-B2
GSTA1 glutathione S-transferase alpha 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
IL13RA2 interleukin 13 receptor, alpha 2
INSIG1 insulin induced gene 1
KIF14 kinesin family member 14
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KYNU kynureninase
LDLR low density lipoprotein receptor
LIPG lipase, endothelial
MGP matrix Gla protein
MGST3 microsomal glutathione S-transferase 3
MRPL17 mitochondrial ribosomal protein L17
MSMO1 methylsterol monooxygenase 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
S100A9 S100 calcium binding protein A9
SATB1 SATB homeobox 1
SEPP1 selenoprotein P, plasma, 1
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SPRR1B small proline-rich protein 1B
SQLE squalene epoxidase
STK26 serine/threonine protein kinase 26
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSKU tsukushi, small leucine rich proteoglycan
TSPAN8 tetraspanin 8